The Neuroprotective Effects of Decursin Isolated from Angelica gigas Nakai Against Amyloid β-Protein-Induced Apoptosis in PC 12 Cells via a Mitochondria-Related Caspase Pathway

Ahn KS, Sim WS, Kim IH (1996) Decursin: acytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med 62:7–9 Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817–827 Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (1999) Biochemical pathways of caspase activation during apoptosis. Annurev Cell Dev Bi 15:269–290 Bulat N, Widmann C (2009) Caspase substrates and neurodegenerative diseases. Brain Res Bull 80:251–267 Cheung ZH, Leung MC, Yip HK, Wu W, Siu FK, So KF (2008) A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells. Cell Mol Neurobiol 28:137–155 Cho SK, AbdEl-Aty AM, Choi JH, Kim MR, Shim JH (2007) Optimized conditions for the extraction of secondary volatilemet abolitesin Angelica roots by accelerated solvent extraction. J Pharmaceut Biomed 44:1154–1158 Desagher S, Martinou JC (2000) Mitochondria as the central control point of apoptosis. Trends Cell Biol 10(9):369–377 Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer’s disease brain is associated with mitochondrial dysfunction. J Neurosci 26:9057–9068 Dumont M, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT (2009) Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase over expression in a transgenic mouse model of Alzheimer’s disease. FASEB J 23:2459–2466 Eckert A, Hauptmann S, Scherping I, Rhein V, Muller-Spahn F, Götz J, Muller WE (2008) Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener Dis 5:157–159 Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO (1989) Prevalence of Alzheimer’s disease in a community population of older persons. JAMA 262:2551–2556 Hardy H (1997) Amyloid, the presenilins and Alzheimer’s disease. Trends Neurosci 20:154–159 Joo SS, Park DS, Shin SH, Jeon JH, Kim TK, Choi YJ, Lee SH, Kim JS, ParkSK HB, Lee DI, Kim YB (2010) Anti-allergic effects and mechanismsof action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced in flammation models. Environ Toxicol Pharmacol 30:127–133 Kang SY, Lee KY, Park MJ (2003) Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol Learn Mem 79:11–18 Kang SY, Lee KY, Sung DH (2005) Four new neuroprotective dihydropyranocoumarins from Angelica gigas. J Nat Prod 68(1):56–59 Kang SY, Kim YC (2007) Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. J Pharm Pharmacol 59(6):863–870 Kim DH, Jung WY, Park SJ, Kim JM, Lee SJ, Kim YC, Ryu JH (2010) Antiamnesic effect of ESP-102 on Aβ1-42-induced memory impairment in mice. Pharmacol Biochem Behav 97:239–248 Kim MK, Jung JY, Hwang SW, Kim MJ, Kang JS (2005) Isolation and purification of decrusin and decursinol angelate in Angelica gigas Nakai. J Korean Soc Food Sci Nutr 38(1):653–656 Kim R, Emi M, Tanabe K (2005) Caspase-dependent and -independent cell death pathways after DNA damage. Oncol Rep 14:595–599 Kim WH, Park WB, Gao B, Jung MH (2004) Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells. Mol Pharmacol 66:1383–1396 Korsmeyer SJ (1992) Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80(4):879–886 Kosten TA, Galloway MP, Duman RS, Russell DS, D’Sa C (2008) Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures. Neuropsychopharmacol 33:1545–1558 Lee S, Lee YS, Jung SH, Shin KH, Kim BK, Kang SS (2003) Antioxidant activities of decursinol angelate and decursin from Angelica gigas roots. Arch Pharm Res 26:727–730 Lee YY, Lee S, Jin JL, Yun-Choi HS (2003) Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch Pharm Res 26:723–726 Li G, Ma R, Huang C, Tang Q, Fu Q, Liu H, Hu B, Xiang J (2008) Protective effect of erythropoietin on b-amyloid-induced PC12 cell death through antioxidant mechanisms. Neurosci Lett 442:143–147 Li L, Du JK, Zou LY, Wu T, Lee YW, Kim YH (2013) Decursin isolated from Angelica gigas Nakai rescues PC12 cells from amyloid ß-protein-induced neurotoxicity through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of MAPK. Evid-Based Compl Alt dx. doi:10.1155/2013/467245 Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. P Natl Cad Sci USA 90:7951–7955 Madgula VLM, Avula B, Reddy NVL, Khan IA, Khan SI (2007) Transport of decursin and decursinol angelate across Caco-2 and MDR-MDCK cell monolayers: in vitro models for intestinal and blood–brain barrier permeability. Planta Med 73:330–335 Mao P, Reddy PH (2011) Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer’s disease: implications for early intervention and therapeutics. Biochim Biophys Acta 1812:1359–1370 May MJ, Madge LA (2007) Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species. J Biol Chem 282:16105–16116 Parker WD Jr, Fillery CM, Parks JK (1990) Cytochrome oxidase deficiency in Alzheimer’s disease. Neurology 40:1302–1303 Santos MJ, Quintanilla RA, Toro A, Grandy R, Dinamarca MC, Godoy JA, Inestrosa NC (2005) Peroxisomal proliferation protects from beta-amyloid neurodegeneration. J Biol Chem 280:41057–41068 Selkoe DJ (2000) Toward a comprehensive theory for Alzheimer’sdisease. Hypothesis: alzheimer’s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924:17–25 Shiomi K, Hatano H, Morimoto H, Ui H, Sakamoto K, Kita K, Tomoda H, Lee EW, Heo TR, Kawagishi H, Omura S (2007) Decursin and decursinol angelate selectively inhibit NADH-Fumarate reductase of Ascarissuum. Planta Med 73:1478–1481 Song GY, Lee JH, Cho M, Park BS, Kim DE, Oh S (2007) Decursin suppresses human androgen-independent PC3 prostate cancer cell proliferation by promoting the degradation of beta-catenin. Mol Pharmacol 72:1599–1606 Stefanis L (2005) Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury. Neuroscientist 11:50–62 Tang XQ, Yang CT, Chen J, Yin WL, Tian SW, Hu B, Feng JQ, Li YJ (2008) Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells. Clin Exp Pharmacol Physiol 35:180–186 Wang W, Huang W, Li L, Ai H, Sun F, Liu C, An Y (2008) Morroniside prevents peroxide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells. Cell Mol Neurobiol 28:293–305 Xu HY, Wang HT, Zhuang LX, Yan B, Yu YX, Wei ZL, Zhang XB, Dyck EL, Richardson SJ, He J, Li XK, Kong J, Li XM (2009) Demonstration of an anti-oxidative stress mechanism of quetiapine: implications for the treatment of Alzheimer’s disease. FEBS J 275(14):3718–3728 Zhang HY, Liu YH, Wang HQ, Xu JH, Hu HT (2008) Puerarin protects PC12 cells against β-amyloid-induced cell injury. Cell Biol Int 32:1230–1237