The Neural Tourniquet
Tóm tắt
Bioelectronic medicine aims to understand and harness the beneficial effects of the nervous system and neural circuits to diagnose, treat and prevent disease. For example, targeted electrical stimulation devices can recapitulate endogenous neural signaling and control debilitating symptoms of Parkinson’s disease and epilepsy. Perhaps equally as important, electrical stimulation devices demonstrate efficacy where traditional drug therapies fail. As biomedical research continues to reveal critical neural regulatory pathways, there is tremendous potential to expand and incorporate bioelectronic medicine into current treatment paradigms. In this review, we introduce a recently characterized neural pathway, termed the inflammatory reflex, which monitors and regulates systemic inflammation via afferent and efferent vagus nerve signaling. We then describe how stimulation of the vagus nerve and activation of the inflammatory reflex rapidly and specifically curtail traumatic hemorrhage through a novel mechanism termed the neural tourniquet. Finally, we identify how bioelectronic medicine can help harness the protective effects of vagus nerve signaling and the neural tourniquet to protect patients against surgical and traumatic hemorrhage.
Tài liệu tham khảo
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