The Netherlands Obsessive Compulsive Disorder Association (NOCDA) study: design and rationale of a longitudinal naturalistic study of the course of OCD and clinical characteristics of the sample at baseline

International Journal of Methods in Psychiatric Research - Tập 21 Số 4 - Trang 273-285 - 2012
Josien Schuurmans1, Anton J.L.M. van Balkom2, Harold J.G.M. van Megen3, Johannes H. Smit2, Merijn Eikelenboom2, Daniëlle C. Cath4, Maarten Kaarsemaker5, Désirée B. Oosterbaan6, Gert‐Jan Hendriks7, Koen Schruers8, Nic J.A. van der Wee9, Gerrit Glas10, Patricia van Oppen2
1Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, Amsterdam, The Netherlands
2Department of Psychiatry VU University Medical Centre/GGZ inGeest and EMGO + Institute Amsterdam The Netherlands
3GGZ-centraal, Marina de Wolf Centre for Anxiety Research, Ermelo, The Netherlands
4Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands.
5Mental Health Care Institute Noord‐en Midden Limburg Venray The Netherlands
6Department of Psychiatry, University Medical Centre Nijmegen, Nijmegen, The Netherlands
7Centre for Anxiety Disorders “Overwaal” Lent The Netherlands
8Academic Anxiety Centre, PsyQ Maastricht, Maastricht University Division of Mental Health and Neuroscience Maastricht The Netherlands
9Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands
10Dimence, Almelo, The Netherlands

Tóm tắt

AbstractIn half of Obsessive Compulsive Disorder (OCD) patients the disorder runs a chronic course despite treatment. The factors determining this unfavourable outcome remain unknown.The Netherlands Obsessive Compulsive Disorder Association (NOCDA) study is a multicentre naturalistic cohort study of the biological, psychological and social determinants of chronicity in a clinical sample. Recruitment of OCD patients took place in mental health organizations. Its design is a six‐year longitudinal cohort study among a representative clinical sample of 419 OCD patients. All five measurements within this six‐year period involved validated semi‐structured interviews and self‐report questionnaires which gathered information on the severity of OCD and its co‐morbidity as well as information on general wellbeing, quality of life, daily activities, medical consumption and key psychological and social factors. The baseline measurements also include DNA and blood sampling and data on demographic and personality variables. The current paper presents the design and rationale of the study, as well as data on baseline sample characteristics. Demographic characteristics and co‐morbidity ratings in the NOCDA sample closely resemble other OCD study samples. Lifetime co‐morbid Axis I disorders are present in the majority of OCD patients, with high current and lifetime co‐morbidity ratings for affective disorders (23.4% and 63.7%, respectively) and anxiety disorders other than OCD (36% current and 46.5% lifetime). Copyright © 2012 John Wiley & Sons, Ltd.

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International Journal of Methods in Psychiatric Research

Tập 21 Số 4

273-285

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