The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster

Chemistry & Biology - Tập 7 - Trang 821-831 - 2000
D Hoffmeister1, K Ichinose2, S Domann1,3, B Faust1, A Trefzer1, G Dräger3, A Kirschning3, C Fischer4, E Künzel4, DW Bearden5, J Rohr4, A Bechthold1
1Christian-Albrechts-Universität zu Kiel, Pharmazeutische Biologie, Gutenbergstraße 76, D-24118 Kiel, Germany
2The University of Tokyo, Graduate School of Pharmaceutical Sciences, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
3Technische Universität Clausthal, Institut für Organische Chemie, Leibnizstr. 6, D-38678 Clausthal-Zellerfeld, Germany
4Medical University of South Carolina, Department of Pharmaceutical Sciences, 171 Ashley Avenue, Charleston, SC 29425-2303, USA.
5Center for Coastal Environmental Health and Biomolecular Research, NOAA, National Ocean Service, 219 Fort Johnson Road, Charleston, SC 29412-9110, USA

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Chemistry & Biology

Tập 7

821-831

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