The Microbiome as a Gateway to Prevention of Allergic Disease Development

Lin, 2007, Role of bacterial pathogens in atopic dermatitis, Clin Rev Allergy Immunol, 33, 167, 10.1007/s12016-007-0044-5 Gillissen, 2015, Inflammation and infections in asthma, Clin Respir J, 9, 257, 10.1111/crj.12135 Kuvaeva, 1984, Microecology of the gastrointestinal tract and the immunological status under food allergy, Nahrung, 28, 689, 10.1002/food.19840280645 Kuvaeva, 1980, Functional state of the immunological system and of the gastrointestinal tract in children with a food allergy [in Russian], Vopr Pitan, 33 Loskutova, 1985, Effectiveness of using Maliutka and Malysh adapted propionic-acidophilus mixtures in the combined treatment of congenital hypotrophy [in Russian], Vopr Pitan, 17 Ciprandi, 1986, Effects of an adjunctive treatment with Bacillus subtilis for food allergy, Chemioterapia, 5, 408 Strachan, 1989, Hay fever, hygiene, and household size, BMJ, 299, 1259, 10.1136/bmj.299.6710.1259 Wold, 1998, The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora?, Allergy, 53, 20, 10.1111/j.1398-9995.1998.tb04953.x Kirjavainen, 1999, Healthy gut microflora and allergy: factors influencing development of the microbiota, Ann Med, 31, 288, 10.3109/07853899908995892 Ege, 2011, Exposure to environmental microorganisms and childhood asthma, N Eng J Med, 364, 701, 10.1056/NEJMoa1007302 Kirjavainen, 2019, Farm-like indoor microbiota in non-farm homes protects children from asthma development, Nat Med, 25, 1089, 10.1038/s41591-019-0469-4 Strannegård, 2001, The causes of the increasing prevalence of allergy: is atopy a microbial deprivation disorder?, Allergy, 56, 91, 10.1034/j.1398-9995.2001.056002091.x Rook, 2003, Innate immune responses to mycobacteria and the downregulation of atopic responses, Curr Opin Allergy Clin Immunol, 3, 337, 10.1097/00130832-200310000-00003 Noverr, 2005, The “microflora hypothesis” of allergic diseases, Clin Exp Allergy, 35, 1511, 10.1111/j.1365-2222.2005.02379.x Haahtela, 2013, The biodiversity hypothesis and allergic disease: world allergy organization position statement, World Allergy Organ J, 6, 3, 10.1186/1939-4551-6-3 Holgate, 2012, Innate and adaptive immune responses in asthma, Nat Med, 18, 673, 10.1038/nm.2731 Prescott, 1999, Development of allergen-specific T-cell memory in atopic and normal children, Lancet, 353, 196, 10.1016/S0140-6736(98)05104-6 Smith, 2008, Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function, J Allergy Clin Immunol, 121, 10.1016/j.jaci.2008.03.025 Kirjavainen, 2006, The infant intestinal microbiota in allergy, 189 Hooper, 2012, Interactions between the microbiota and the immune system, Science, 336, 1268, 10.1126/science.1223490 Linneberg, 2003, IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study, J Allergy Clin Immunol, 111, 847, 10.1067/mai.2003.1335 von Mutius, 2007, Allergies, infections and the hygiene hypothesis—the epidemiological evidence, Immunobiology, 212, 433, 10.1016/j.imbio.2007.03.002 Jartti, 2017, Role of viral infections in the development and exacerbation of asthma in children, J Allergy Clin Immunol, 140, 895, 10.1016/j.jaci.2017.08.003 Brunwasser, 2020, Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis, Lancet Respir Med, 8, 795, 10.1016/S2213-2600(20)30109-0 Sudo, 1997, The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction, J Immunol, 159, 1739, 10.4049/jimmunol.159.4.1739 Kim, 1995, Oral tolerance to ovalbumin in mice as a model for detecting modulators of the immunologic tolerance to a specific antigen, Biol Pharm Bull, 18, 854, 10.1248/bpb.18.854 Gaboriau-Routhiau, 1996, Gut flora allows recovery of oral tolerance to ovalbumin in mice after transient breakdown mediated by cholera toxin or Escherichia coli heat-labile enterotoxin, Pediatr Res, 39, 625, 10.1203/00006450-199604000-00011 Feehley, 2019, Healthy infants harbor intestinal bacteria that protect against food allergy, Nat Med, 25, 448, 10.1038/s41591-018-0324-z Sütas, 1996, Down-regulation of anti-CD3 antibody-induced IL-4 production by bovine caseins hydrolysed with Lactobacillus GG-derived enzymes, Scand J Immunol, 43, 687, 10.1046/j.1365-3083.1996.d01-258.x Sütas, 1996, Suppression of lymphocyte proliferation in vitro by bovine caseins hydrolyzed with Lactobacillus casei GG-derived enzymes, J Allergy Clin Immunol, 98, 216, 10.1016/S0091-6749(96)70245-2 Pessi, 2001, Suppression of T-cell activation by Lactobacillus rhamnosus GG-degraded bovine casein, Int Immunopharmacol, 1, 211, 10.1016/S1567-5769(00)00018-7 Hooper, 2000, Analyzing the molecular foundations of commensalism in the mouse intestine, Curr Opin Microbiol, 3, 79, 10.1016/S1369-5274(99)00055-7 Stefka, 2014, Commensal bacteria protect against food allergen sensitization, Proc Natl Acad Sci U S A, 111, 13145, 10.1073/pnas.1412008111 Kirjavainen, 1999, New aspects of probiotics—a novel approach in the management of food allergy, Allergy, 54, 909, 10.1034/j.1398-9995.1999.00103.x Pothoven, 2017, The barrier hypothesis and Oncostatin M: restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease, Tissue Barriers, 5, 10.1080/21688370.2017.1341367 Akdis, 2021, Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?, Nat Rev Immunol, 21, 739, 10.1038/s41577-021-00538-7 Navarro, 2011, The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways, Mucosal Immunol, 4, 53, 10.1038/mi.2010.51 Strickland, 2011, Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control, Mucosal Immunol, 4, 43, 10.1038/mi.2010.43 Trompette, 2014, Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis, Nat Med, 20, 159, 10.1038/nm.3444 Gollwitzer, 2014, Lung microbiota promotes tolerance to allergens in neonates via PD-L1, Nat Med, 20, 642, 10.1038/nm.3568 Olszak, 2012, Microbial exposure during early life has persistent effects on natural killer T cell function, Science, 336, 489, 10.1126/science.1219328 Lezmi, 2018, Invariant natural killer T and mucosal-associated invariant T cells in asthmatic patients, Front Immunol, 9, 1766, 10.3389/fimmu.2018.01766 Arildsen, 2021, Delayed gut colonization shapes future allergic responses in a murine model of atopic dermatitis, Front Immunol, 12, 10.3389/fimmu.2021.650621 Zachariassen, 2017, Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice, Sci Rep, 7, 10.1038/srep44385 Dominguez-Bello, 2010, Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns, Proc Natl Acad Sci U S A, 107, 11971, 10.1073/pnas.1002601107 Chu, 2017, Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery, Nat Med, 23, 314, 10.1038/nm.4272 Fieten, 2018, Fecal microbiome and food allergy in pediatric atopic dermatitis: a cross-sectional pilot study, Int Arch Allergy Immunol, 175, 77, 10.1159/000484897 Jensen-Jarolim, 2017, Outstanding animal studies in allergy II. From atopic barrier and microbiome to allergen-specific immunotherapy, Curr Opin Allergy Clin Immunol, 17, 180, 10.1097/ACI.0000000000000364 Ramsey, 2016, Staphylococcus aureus shifts toward commensalism in response to Corynebacterium species, Front Microbiol, 7, 1230, 10.3389/fmicb.2016.01230 Fyhrquist, 2014, Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation, J Allergy Clin Immunol, 134, 1301, 10.1016/j.jaci.2014.07.059 Kong, 2012, Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis, Genome Res, 22, 850, 10.1101/gr.131029.111 Meylan, 2017, Skin colonization by Staphylococcus aureus precedes the clinical diagnosis of atopic dermatitis in infancy, J Invest Dermatol, 137, 2497, 10.1016/j.jid.2017.07.834 Nakatsuji, 2016, Staphylococcus aureus exploits epidermal barrier defects in atopic dermatitis to trigger cytokine expression, J Invest Dermatol, 136, 2192, 10.1016/j.jid.2016.05.127 Kennedy, 2017, Skin microbiome before development of atopic dermatitis: early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year, J Allergy Clin Immunol, 139, 166, 10.1016/j.jaci.2016.07.029 Seite, 2015, Barrier function and microbiotic dysbiosis in atopic dermatitis, Clin Cosmet Investig Dermatol, 8, 479, 10.2147/CCID.S91521 Geoghegan, 2018, Mechanomicrobiology: how mechanical forces activate Staphylococcus aureus adhesion, Trends Microbiol, 26, 645, 10.1016/j.tim.2018.05.004 Keski-Nisula, 1997, Cesarean delivery. Microbial colonization in amniotic fluid, J Reprod Med, 42, 91 Mishra, 2021, Microbial exposure during early human development primes fetal immune cells, Cell, 184, 3394, 10.1016/j.cell.2021.04.039 Rackaityte, 2020, Viable bacterial colonization is highly limited in the human intestine in utero, Nat Med, 26, 599, 10.1038/s41591-020-0761-3 Yassour, 2016, Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability, Sci Transl Med, 8, 343ra81, 10.1126/scitranslmed.aad0917 Yatsunenko, 2012, Human gut microbiome viewed across age and geography, Nature, 486, 222, 10.1038/nature11053 Durack, 2018, Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation, Nat Commun, 9, 707, 10.1038/s41467-018-03157-4 Bisgaard, 2011, Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age, J Allergy Clin Immunol, 128, 646, 10.1016/j.jaci.2011.04.060 Arrieta, 2015, Early infancy microbial and metabolic alterations affect risk of childhood asthma, Sci Transl Med, 7, 10.1126/scitranslmed.aab2271 Fujimura, 2016, Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation, Nat Med, 22, 1187, 10.1038/nm.4176 Depner, 2020, Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma, Nat Med, 26, 1766, 10.1038/s41591-020-1095-x Stokholm, 2018, Maturation of the gut microbiome and risk of asthma in childhood, Nat Commun, 9, 141, 10.1038/s41467-017-02573-2 Kalliomäki, 2001, Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing, J Allergy Clin Immunol, 107, 129, 10.1067/mai.2001.111237 Fazlollahi, 2018, Early-life gut microbiome and egg allergy, Allergy, 73, 1515, 10.1111/all.13389 Berni Canani, 2016, Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants, ISME J, 10, 742, 10.1038/ismej.2015.151 Bunyavanich, 2016, Early-life gut microbiome composition and milk allergy resolution, J Allergy Clin Immunol, 138, 1122, 10.1016/j.jaci.2016.03.041 Lathrop, 2011, Peripheral education of the immune system by colonic commensal microbiota, Nature, 478, 250, 10.1038/nature10434 Geuking, 2011, Intestinal bacterial colonization induces mutualistic regulatory T cell responses, Immunity, 34, 794, 10.1016/j.immuni.2011.03.021 Arpaia, 2013, Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation, Nature, 504, 451, 10.1038/nature12726 Furusawa, 2013, Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells, Nature, 504, 446, 10.1038/nature12721 Roduit, 2019, High levels of butyrate and propionate in early life are associated with protection against atopy, Allergy, 74, 799, 10.1111/all.13660 Penders, 2006, Factors influencing the composition of the intestinal microbiota in early infancy, Pediatrics, 118, 511, 10.1542/peds.2005-2824 Thomas, 2017, The microbiome and atopic eczema: more than skin deep, Australas J Dermatol, 58, 18, 10.1111/ajd.12435 Abrahamsson, 2012, Low diversity of the gut microbiota in infants with atopic eczema, J Allergy Clin Immunol, 129, 10.1016/j.jaci.2011.10.025 Fleischer, 2021, J Allergy Clin Immunol Pract, 9, 22, 10.1016/j.jaip.2020.11.002 Teo, 2015, The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development, Cell Host Microbe, 17, 704, 10.1016/j.chom.2015.03.008 McCauley, 2019, Distinct nasal airway bacterial microbiota differentially relate to exacerbation in pediatric asthma, J Allergy Clin Immunol, 144, 1187, 10.1016/j.jaci.2019.05.035 Teo, 2018, Airway microbiota dynamics uncover a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease, Cell Host Microbe, 24, 341, 10.1016/j.chom.2018.08.005 Hyde, 2014, Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis, J Allergy Clin Immunol, 133, 1220, 10.1016/j.jaci.2013.10.049 Tang, 2021, Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk, J Allergy Clin Immunol, 147, 1683, 10.1016/j.jaci.2020.10.009 Toivonen, 2020, Longitudinal changes in early nasal microbiota and the risk of childhood asthma, Pediatrics, 146, 10.1542/peds.2020-0421 Rosas-Salazar, 2018, Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy, J Allergy Clin Immunol, 142, 1447, 10.1016/j.jaci.2017.10.049 Biesbroek, 2014, Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children, Am J Respir Crit Care Med, 190, 1283, 10.1164/rccm.201407-1240OC Calışkan, 2013, Rhinovirus wheezing illness and genetic risk of childhood-onset asthma, N Engl J Med, 368, 1398, 10.1056/NEJMoa1211592 Chun, 2020, Integrative study of the upper and lower airway microbiome and transcriptome in asthma, JCI Insight, 5, 10.1172/jci.insight.133707 McCauley, 2022, Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations, J Allergy Clin Immunol, 150, 204, 10.1016/j.jaci.2022.01.020 Bosch, 2017, Maturation of the infant respiratory microbiota, environmental drivers, and health consequences. A prospective cohort study, Am J Respir Crit Care Med, 196, 1582, 10.1164/rccm.201703-0554OC Kloepfer, 2017, Community-acquired rhinovirus infection is associated with changes in the airway microbiome, J Allergy Clin Immunol, 140, 312, 10.1016/j.jaci.2017.01.038 Bisgaard, 2007, Childhood asthma after bacterial colonization of the airway in neonates, N Eng J Med, 357, 1487, 10.1056/NEJMoa052632 Depner, 2017, Bacterial microbiota of the upper respiratory tract and childhood asthma, J Allergy Clin Immunol, 139, 826, 10.1016/j.jaci.2016.05.050 McCauley, 2021, Moraxella-dominated pediatric nasopharyngeal microbiota associate with upper respiratory infection and sinusitis, PLoS One, 16, 10.1371/journal.pone.0261179 Hassan, 2012, Moraxella catarrhalis activates murine macrophages through multiple toll like receptors and has reduced clearance in lungs from TLR4 mutant mice, PLoS One, 7, 10.1371/journal.pone.0037610 Alnahas, 2017, IL-17 and TNF-α are key mediators of Moraxella catarrhalis triggered exacerbation of allergic airway inflammation, Front Immunol, 8, 1562, 10.3389/fimmu.2017.01562 Stras, 2019, Maturation of the human intestinal immune system occurs early in fetal development, Dev Cell, 51, 357, 10.1016/j.devcel.2019.09.008 Litonjua, 2016, Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial, JAMA, 315, 362, 10.1001/jama.2015.18589 Bisgaard, 2016, Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring, N Engl J Med, 375, 2530, 10.1056/NEJMoa1503734 Sordillo, 2017, Factors influencing the infant gut microbiome at age 3-6 months: findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART), J Allergy Clin Immunol, 139, 482, 10.1016/j.jaci.2016.08.045 Hjelmsø, 2020, Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial, Nat Commun, 11, 426, 10.1038/s41467-020-14308-x Litonjua, 2020, Six-year follow-up of a trial of antenatal vitamin D for asthma reduction, N Engl J Med, 382, 525, 10.1056/NEJMoa1906137 Venter, 2022, The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study, Allergy, 77, 162, 10.1111/all.14949 Aslam, 2021, Gut microbiome diversity and composition are associated with habitual dairy intakes: a cross-sectional study in men, J Nutr, 151, 3400 Fan, 2021, Maternal vegetable and fruit consumption during pregnancy and its effects on infant gut microbiome, Nutrients, 13, 1559, 10.3390/nu13051559 Thorburn, 2015, Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites, Nat Commun, 6, 7320, 10.1038/ncomms8320 Lisko, 2017, Effects of dietary yogurt on the healthy human gastrointestinal (GI) microbiome, Microorganisms, 5, 6, 10.3390/microorganisms5010006 Le Roy, 2022, Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome, BMC Microbiol, 22, 39, 10.1186/s12866-021-02364-2 Madison, 2019, Stress, depression, diet, and the gut microbiota: human-bacteria interactions at the core of psychoneuroimmunology and nutrition, Curr Opin Behav Sci, 28, 105, 10.1016/j.cobeha.2019.01.011 Andersson, 2016, Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies, Allergy, 71, 15, 10.1111/all.12762 Smejda, 2018, Maternal stress during pregnancy and allergic diseases in children during the first year of life, Respir Care, 63, 70, 10.4187/respcare.05692 Gao, 2018, Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response, Proc Natl Acad Sci U S A, 115, E2960, 10.1073/pnas.1720696115 Jašarević, 2017, Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner, Sci Rep, 7, 10.1038/srep44182 Antonson, 2020, Unique maternal immune and functional microbial profiles during prenatal stress, Sci Rep, 10, 10.1038/s41598-020-77265-x Duran-Pinedo, 2018, The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome, NPJ Biofilms Microbiomes, 4, 25, 10.1038/s41522-018-0068-z Hantsoo, 2019, Childhood adversity impact on gut microbiota and inflammatory response to stress during pregnancy, Brain Behav Immun, 75, 240, 10.1016/j.bbi.2018.11.005 Jašarević, 2018, The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus, Nat Neurosci, 21, 1061, 10.1038/s41593-018-0182-5 Jašarević, 2015, Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain, Endocrinology, 156, 3265, 10.1210/en.2015-1177 Zijlmans, 2015, Maternal prenatal stress is associated with the infant intestinal microbiota, Psychoneuroendocrinology, 53, 233, 10.1016/j.psyneuen.2015.01.006 Aatsinki, 2020, Maternal prenatal psychological distress and hair cortisol levels associate with infant fecal microbiota composition at 2.5 months of age, Psychoneuroendocrinology, 119, 10.1016/j.psyneuen.2020.104754 Zhong, 2019, Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children, Microbiome, 7, 2, 10.1186/s40168-018-0608-z Li, 2021, Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study, BMJ Open, 11, 10.1136/bmjopen-2020-047768 Pennington, 2018, Caesarean delivery, childhood asthma, and effect modification by sex: an observational study and meta-analysis, Paediatr Perinat Epidemiol, 32, 495, 10.1111/ppe.12510 Stokholm, 2020, Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma, Sci Transl Med, 12, 10.1126/scitranslmed.aax9929 Ren, 2015, Effects of Bifidobacterium breve feeding strategy and delivery modes on experimental allergic rhinitis mice, PLoS One, 10, 10.1371/journal.pone.0140018 Bosch, 2016, Development of upper respiratory tract microbiota in infancy is affected by mode of delivery, EBioMedicine, 9, 336, 10.1016/j.ebiom.2016.05.031 Koletzko, 2005, Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group, J Pediatr Gastroenterol Nutr, 41, 584, 10.1097/01.mpg.0000187817.38836.42 Bäckhed, 2015, Dynamics and stabilization of the human gut microbiome during the first year of life, Cell Host Microbe, 17, 690, 10.1016/j.chom.2015.04.004 Dogaru, 2014, Breastfeeding and childhood asthma: systematic review and meta-analysis, Am J Epidemiol, 179, 1153, 10.1093/aje/kwu072 Roduit, 2014, Increased food diversity in the first year of life is inversely associated with allergic diseases, J Allergy Clin Immunol, 133, 1056, 10.1016/j.jaci.2013.12.1044 Biesbroek, 2014, The impact of breastfeeding on nasopharyngeal microbial communities in infants, Am J Respir Crit Care Med, 190, 298, 10.1164/rccm.201401-0073OC Sriraman, 2016, Breastfeeding: what are the barriers? Why women struggle to achieve their goals, J Womens Health (Larchmt), 25, 714, 10.1089/jwh.2014.5059 Oncel, 2014, Lactobacillus reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial, Arch Dis Child Fetal Neonatal, 99, F110, 10.1136/archdischild-2013-304745 Borewicz, 2019, The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life, Sci Rep, 9, 2434, 10.1038/s41598-018-38268-x Bokulich, 2016, Antibiotics, birth mode, and diet shape microbiome maturation during early life, Sci Transl Med, 8, 343ra82, 10.1126/scitranslmed.aad7121 Ahmadizar, 2018, Early-life antibiotic exposure increases the risk of developing allergic symptoms later in life: a meta-analysis, Allergy, 73, 971, 10.1111/all.13332 Ahmadizar, 2017, Early life antibiotic use and the risk of asthma and asthma exacerbations in children, Pediatr Allergy Immunol, 28, 430, 10.1111/pai.12725 Semic-Jusufagic, 2014, Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study, Lancet Respir Med, 2, 621, 10.1016/S2213-2600(14)70096-7 Crane, 2014, Antibiotics and asthma: a tricky tributary of the hygiene hypothesis, Lancet Respir Med, 2, 595, 10.1016/S2213-2600(14)70109-2 Marra, 2009, Antibiotic use in children is associated with increased risk of asthma, Pediatrics, 123, 1003, 10.1542/peds.2008-1146 Reyman, 2019, Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life, Nat Commun, 10, 4997, 10.1038/s41467-019-13014-7 Dethlefsen, 2011, Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation, Proc Natl Acad Sci U S A, 108, 4554, 10.1073/pnas.1000087107 Jernberg, 2007, Long-term ecological impacts of antibiotic administration on the human intestinal microbiota, ISME J, 1, 56, 10.1038/ismej.2007.3 Avis, 2021, Targeted microbiome-sparing antibiotics, Drug Discov Today, 26, 2198, 10.1016/j.drudis.2021.07.016 Bergroth, 2020, Rhinovirus type in severe bronchiolitis and the development of asthma, J Allergy Clin Immunol Pract, 8, 588, 10.1016/j.jaip.2019.08.043 Edwards, 2017, Viral infections in allergy and immunology: how allergic inflammation influences viral infections and illness, J Allergy Clin Immunol, 140, 909, 10.1016/j.jaci.2017.07.025 Busse, 2010, The role of viral respiratory infections in asthma and asthma exacerbations, Lancet, 376, 826, 10.1016/S0140-6736(10)61380-3 Chu, 2013, Molecular epidemiology of respiratory syncytial virus transmission in childcare, J Clin Virol, 57, 343, 10.1016/j.jcv.2013.04.011 Martin, 2018, Heterotypic infection and spread of rhinovirus A, B, and C among childcare attendees, J Infect Dis, 218, 848, 10.1093/infdis/jiy232 Fairchok, 2010, Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare, J Clin Virol, 49, 16, 10.1016/j.jcv.2010.06.013 Thompson, 2015, Milk- and solid-feeding practices and daycare attendance are associated with differences in bacterial diversity, predominant communities, and metabolic and immune function of the infant gut microbiome, Front Cell Infect Microbiol, 5, 3, 10.3389/fcimb.2015.00003 Amir, 2022, Gut microbiome development in early childhood is affected by day care attendance, NPJ Biofilms Microbiomes, 8, 2, 10.1038/s41522-021-00265-w Roslund, 2019, Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children, Environ Int, 130, 10.1016/j.envint.2019.06.004 Accorsi, 2020, Determinants of Staphylococcus aureus carriage in the developing infant nasal microbiome, Genome Biol, 21, 301, 10.1186/s13059-020-02209-7 Cheng, 2014, Duration of day care attendance during infancy predicts asthma at the age of seven: the Cincinnati Childhood Allergy and Air Pollution Study, Clin Exp Allergy, 44, 1274, 10.1111/cea.12397 Tokinobu, 2020, Association of early daycare attendance with allergic disorders in children: a longitudinal national survey in Japan, Arch Environ Occup Health, 75, 18, 10.1080/19338244.2018.1535481 Gaffin, 2012, Effect of cat and daycare exposures on the risk of asthma in children with atopic dermatitis, Allergy Asthma Proc, 33, 282, 10.2500/aap.2012.33.3572 Lynch, 2014, Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children, J Allergy Clin Immunol, 134, 593, 10.1016/j.jaci.2014.04.018 Ege, 2008, Prenatal exposure to a farm environment modifies atopic sensitization at birth, J Allergy Clin Immunol, 122, 10.1016/j.jaci.2008.06.011 Tischer, 2022, Interplay between natural environment, human microbiota and immune system: a scoping review of interventions and future perspectives towards allergy prevention, Sci Total Environ, 821, 10.1016/j.scitotenv.2022.153422 Sitarik, 2018, Dog introduction alters the home dust microbiota, Indoor Air, 28, 539, 10.1111/ina.12456 Chen, 2008, Dog ownership and contact during childhood and later allergy development, Eur Respir J, 31, 963, 10.1183/09031936.00092807 Havstad, 2011, Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood, J Allergy Clin Immunol, 128, 880, 10.1016/j.jaci.2011.06.039 Hesselmar, 2018, Pet-keeping in early life reduces the risk of allergy in a dose-dependent fashion, PLoS One, 13, 10.1371/journal.pone.0208472 Mäki, 2021, Associations between dog keeping and indoor dust microbiota, Sci Rep, 11, 5341, 10.1038/s41598-021-84790-w Simpson, 2020, Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence, J Allergy Clin Immunol, 145, 993, 10.1016/j.jaci.2019.08.041 Lloyd, 2019, Opening the window of immune opportunity: treating childhood asthma, Trends Immunol, 40, 786, 10.1016/j.it.2019.07.004 Westman, 2017, Windows of opportunity for tolerance induction for allergy by studying the evolution of allergic sensitization in birth cohorts, Seminars Immunol, 30, 61, 10.1016/j.smim.2017.07.005 Jones, 2022, Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study, Lancet, 399, 359, 10.1016/S0140-6736(21)02390-4 Lampi, 2011, Farming environment and prevalence of atopy at age 31: prospective birth cohort study in Finland, Clin Exp Allergy, 41, 987, 10.1111/j.1365-2222.2011.03777.x Eriksson, 2010, Growing up on a farm leads to lifelong protection against allergic rhinitis, Allergy, 65, 1397, 10.1111/j.1398-9995.2010.02397.x Elholm, 2013, Become a farmer and avoid new allergic sensitization: adult farming exposures protect against new-onset atopic sensitization, J Allergy Clin Immunol, 132, 1239, 10.1016/j.jaci.2013.07.003