The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo

Cell Metabolism - Tập 20 Số 6 - Trang 1018-1029 - 2014
Brandon L. Panaro1, Iain R. Tough2, Maja S. Engelstoft3,4,5, Robert T. Matthews1, Gregory J. Digby1, Cathrine Laustrup Møller6,4,5, Berit Svendsen7,5, Fiona M. Gribble8, Frank Reimann8, Jens J. Holst3,5, Birgitte Holst4,5, Thue W. Schwartz4,5, Helen M. Cox2, Roger D. Cone1
1Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
2King’s College London, Wolfson Centre for Age-Related Diseases, Guy’s Campus, London SE1 1UL, UK
3Danish Diabetes Academy, 5000 Odense, Denmark
4Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Medical and Health Sciences, University of Copenhagen, 2200 Denmark
5Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Medical and Health Sciences, University of Copenhagen, 2200 Denmark
6Diabetes and Obesity Biology, Novo Nordisk A/S, 2760 Maaloev, Denmark
7Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200 Denmark
8University of Cambridge, Cambridge Institute for Medical Research (CIMR) & MRC Metabolic Diseases Unit (MDU), Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK

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