The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo
Tóm tắt
Từ khóa
Tài liệu tham khảo
Arantes, 1997, Distribution of enteroglucagon- and peptide YY-immunoreactive cells in the intestinal mucosa of germ-free and conventional mice, Cell Tissue Res., 290, 61, 10.1007/s004410050908
Balthasar, 2004, Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis, Neuron, 42, 983, 10.1016/j.neuron.2004.06.004
Batterham, 2002, Gut hormone PYY(3-36) physiologically inhibits food intake, Nature, 418, 650, 10.1038/nature00887
Butler, 2001, Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat, Nat. Neurosci., 4, 605, 10.1038/88423
Cone, 2005, Anatomy and regulation of the central melanocortin system, Nat. Neurosci., 8, 571, 10.1038/nn1455
Cox, 2002, Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa, Br. J. Pharmacol., 135, 1505, 10.1038/sj.bjp.0704604
Cox, 2001, Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa, Peptides, 22, 445, 10.1016/S0196-9781(01)00355-2
Cox, 2010, Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses, Cell Metab., 11, 532, 10.1016/j.cmet.2010.04.014
Drucker, 1994, Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line, Mol. Endocrinol., 8, 1646
Egerod, 2012, A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin, Endocrinology, 153, 5782, 10.1210/en.2012-1595
Elliott, 1993, Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns, J. Endocrinol., 138, 159, 10.1677/joe.0.1380159
Engelstoft, 2013, Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells, Mol. Metab., 2, 376, 10.1016/j.molmet.2013.08.006
Fan, 2004, Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system, Nat. Neurosci., 7, 335, 10.1038/nn1214
Gautron, 2010, Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions, J. Comp. Neurol., 518, 6, 10.1002/cne.22221
Gerbe, 2011, Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium, J. Cell Biol., 192, 767, 10.1083/jcb.201010127
Graham, 1997, Overexpression of Agrt leads to obesity in transgenic mice, Nat. Genet., 17, 273, 10.1038/ng1197-273
Greenfield, 2009, Modulation of blood pressure by central melanocortinergic pathways, N. Engl. J. Med., 360, 44, 10.1056/NEJMoa0803085
Grill, 1998, Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight, J. Neurosci., 18, 10128, 10.1523/JNEUROSCI.18-23-10128.1998
Hruby, 1995, Cyclic lactam α-melanotropin analogues of Ac-Nle4-c[Asp4,D-Phe7, Lys10]α-MSH(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors, J. Med. Chem., 38, 3454, 10.1021/jm00018a005
Hsiung, 2005, A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats, Endocrinology, 146, 5257, 10.1210/en.2005-0177
Huszar, 1997, Targeted disruption of the melanocortin-4 receptor results in obesity in mice, Cell, 88, 131, 10.1016/S0092-8674(00)81865-6
Hyland, 2003, Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues, Br. J. Pharmacol., 139, 863, 10.1038/sj.bjp.0705298
Iqbal, 2010, An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption, J. Lipid Res., 51, 1929, 10.1194/jlr.M005744
Kievit, 2013, Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques, Diabetes, 62, 490, 10.2337/db12-0598
Lal, 2004, Cholecystokinin pathways modulate sensations induced by gastric distension in humans, Am. J. Physiol. Gastrointest. Liver Physiol., 287, G72, 10.1152/ajpgi.00351.2003
Liu, 2003, Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter, J. Neurosci., 23, 7143, 10.1523/JNEUROSCI.23-18-07143.2003
Mannon, 1999, Peptide YY/neuropeptide Y Y1 receptor expression in the epithelium and mucosal nerves of the human colon, Regul. Pept., 83, 11, 10.1016/S0167-0115(99)00035-X
Mountjoy, 1994, Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain, Mol. Endocrinol., 8, 1298
Ollmann, 1997, Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein, Science, 278, 135, 10.1126/science.278.5335.135
Panaro, 2013, Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods, Proc. Natl. Acad. Sci. USA, 110, 7050, 10.1073/pnas.1304707110
Parker, 2009, Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells, Diabetologia, 52, 289, 10.1007/s00125-008-1202-x
Pilichiewicz, 2006, Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men, Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, R668, 10.1152/ajpregu.00606.2005
Reimann, 2008, Glucose sensing in L cells: a primary cell study, Cell Metab., 8, 532, 10.1016/j.cmet.2008.11.002
Richardson, 2013, Melanocortin signaling in the brainstem influences vagal outflow to the stomach, J. Neurosci., 33, 13286, 10.1523/JNEUROSCI.0780-13.2013
Samuel, 2008, Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41, Proc. Natl. Acad. Sci. USA, 105, 16767, 10.1073/pnas.0808567105
Schwartz, 2010, An enteroendocrine full package solution, Cell Metab., 11, 445, 10.1016/j.cmet.2010.05.008
Shaw, 2005, Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice, Peptides, 26, 1720, 10.1016/j.peptides.2004.12.026
Tanaka, 1982, Presence of immunoreactive gamma-melanocyte-stimulating hormone, adrenocorticotropin, and beta-endorphin in human gastric antral mucosa, J. Clin. Endocrinol. Metab., 54, 392, 10.1210/jcem-54-2-392
Tough, 2011, Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y1 and Y2 receptors, Br. J. Pharmacol., 164, 471, 10.1111/j.1476-5381.2011.01401.x
Vergoni, 1998, Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats, Eur. J. Pharmacol., 362, 95, 10.1016/S0014-2999(98)00753-5