The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1

Russell J. Pearson1,2, David G. Blake3, Mokdad Mezna3, Peter M. Fischer4, Nicholas J. Westwood1, Campbell McInnes3,5
1Department of Chemistry, University of St Andrews, Fife KY16 9ST, UK
2School of Pharmacy, Keele University, Staffordshire ST5 5BG, UK
3Cyclacel Ltd., James Lindsay Place, Dundee DD1 5JJ, UK
4School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, NG7 2RD, UK
5Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC 29208, USA

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