The Mechanics of Traumatic Brain Injury: A Review of What We Know and What We Need to Know for Reducing Its Societal Burden

Journal of Biomechanical Engineering - Tập 136 Số 2 - 2014
David F. Meaney1, Barclay Morrison2, Cameron Dale Bass3
1Departments of Bioengineering and Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104-6392 e-mail:
2**Department of Biomedical Engineering, Columbia University, New York, NY 10027
3Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281

Tóm tắt

Traumatic brain injury (TBI) is a significant public health problem, on pace to become the third leading cause of death worldwide by 2020. Moreover, emerging evidence linking repeated mild traumatic brain injury to long-term neurodegenerative disorders points out that TBI can be both an acute disorder and a chronic disease. We are at an important transition point in our understanding of TBI, as past work has generated significant advances in better protecting us against some forms of moderate and severe TBI. However, we still lack a clear understanding of how to study milder forms of injury, such as concussion, or new forms of TBI that can occur from primary blast loading. In this review, we highlight the major advances made in understanding the biomechanical basis of TBI. We point out opportunities to generate significant new advances in our understanding of TBI biomechanics, especially as it appears across the molecular, cellular, and whole organ scale.

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Tài liệu tham khảo

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