The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Nature - Tập 452 Số 7184 - Trang 230-233 - 2008
Heather R. Christofk1, Matthew G. Vander Heiden1, Marian H. Harris2, Arvind Ramanathan3, Robert E. Gerszten3,4, Ru Wei3, Mark D. Fleming2, Stuart L. Schreiber3,5, Lewis C. Cantley1,6
1Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
2Department of Pathology, Children’s Hospital, Boston, Massachusetts 02115, USA,
3Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA,
4Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis, Harvard Medical School, Boston, Massachusetts 02115, USA,
5Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 USA
6Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA

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