The Liver

Ayesh, 1989, Genetic polymorphism in human toxicology, Recent Adv Clin Pharmacol Toxicol, 4, 137 Beaune, 1987, Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P450 that hydroxylates the drug, Proc Natl Acad Sci USA, 84, 551, 10.1073/pnas.84.2.551 Bellomo, 1985, Altered thiol and calcium homeostasis in oxidative hepatocellular injury, Hepatology, 5, 876, 10.1002/hep.1840050529 Benjamin, 1985, The morphologic spectrum of halothane-induced hepatitis injury. Analysis of 77 cases, Hepatology, 5, 1163, 10.1002/hep.1840050617 Bird, 1989, Detection of antibodies to a halothane metabolite hapten in sera from patients with halothane-associated hepatitis, J Hepatol, 9, 366, 10.1016/0168-8278(89)90147-5 Black, 1975, Isoniazid-associated hepatitis in 114 patients, Gastroenterology, 69, 289, 10.1016/S0016-5085(19)32568-5 Black, 1984, Acetaminophen hepatotoxicity, Annu Rev Med, 34, 577, 10.1146/annurev.me.35.020184.003045 Black, 1986, Acetaminophen, alcohol, and cytochrome P-450, Ann Intern Med, 104, 427, 10.7326/0003-4819-104-3-427 Boyer, 1978, Mechanisms of chlorpromazine cholestasis: Hypersensitivity or toxic metabolite?, Gastroenterology, 74, 1331, 10.1016/0016-5085(78)90718-7 DeGroot, 1983, Halothane hepatotoxicity: Relation between metabolic activation, hypoxia, covalent binding, lipid peroxidation and liver cell damage, Hepatology, 3, 601 Edmond, 1989, Liver transplantation in the management of fulminant hepatic failure, Gastroenterology, 96, 1583, 10.1016/0016-5085(89)90530-1 Eliastim, 1971, Hepatitis, arthritis and lupus cell phenomena caused by methyldopa, Am J Dig Dis, 16, 1014, 10.1007/BF02235014 Farrell, 1985, Halothane hepatitis: Detection of a constitutional susceptibility factor, N Engl J Med, 313, 1310, 10.1056/NEJM198511213132102 Gillette, 1979, Effects of induction of cytochrome P-450 enzymes on the concentrations of foreign compounds and their metabolites and on the toxicological effect of these compounds, Drug Metab Rev, 10, 59, 10.3109/03602537908993901 Grant, 1990, Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyl-transferase in human liver, J Clin Invest, 85, 968, 10.1172/JCI114527 Gumucio, 1988, Liver cell heterogeneity and liver function, 931 Homberg, 1984, A new anti-liver-kidney microsome antibody (LKM2) in tienilic acid-induced hepatitis, Clin Exp Immunol, 55, 561 Homberg, 1985, Drug-induced hepatitis with antiintracytoplasmic organelle autoantibodies, Hepatology, 5, 722, 10.1002/hep.1840050504 Jungermann, 1989, Functional specialization of different hepatocyte populations, Physiol Rev, 69, 708, 10.1152/physrev.1989.69.3.708 Kaplowitz, 1985, The regulation of hepatic glutathione, Annu Rev Pharmacol Toxicol, 25, 715, 10.1146/annurev.pa.25.040185.003435 Kaplowitz, 1986, Drug-induced hepatotoxicity, Ann Intern Med, 104, 826, 10.7326/0003-4819-104-6-826 Karch, 1977, Toward the operational identification of adverse drug reactions, Clin Pharmacol Ther, 21, 247, 10.1002/cpt1977213247 Kupfer, 1983, Inherited defects of hepatic drug metabolism, Semin Liver Dis, 3, 341, 10.1055/s-2008-1040786 Lewis, 1989, Drug-induced liver disease, Med Clin North Am, 73, 775, 10.1016/S0025-7125(16)30638-1 Loeper, 1989, Presence of convalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of Isaxone, a drug leading to immunoallergic hepatitis in man, Hepatology, 9, 675, 10.1002/hep.1840090503 Mackay, 1985, Induction by drugs of hepatitis and autoantibodies to cell organelles: Significance and interpretation, Hepatology, 5, 904, 10.1002/hep.1840050534 Maddrey, 1977, Drug-induced chronic liver disease, Gastroenterology, 72, 1348, 10.1016/S0016-5085(77)80042-5 Manns, 1989, Autoantibodies and antigens in liver diseases—updated, J Hepatol, 9, 272, 10.1016/0168-8278(89)90063-9 Manns, 1989, The major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P-450 dbl, J Clin Invest, 83, 1066, 10.1172/JCI113949 Meier, 1983, Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation, Gastroenterology, 85, 682, 10.1016/0016-5085(83)90026-4 Mitchell, 1973, Acetaminophen-induced hepatic necrosis. I. The role of drug metabolism, J Pharmacol Exp Ther, 187, 185 Mitchell, 1973, Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione, J Pharmacol Exp Ther, 187, 211 Mitchell, 1975, Metabolic activation of drugs to toxic substances, Gastroenterology, 68, 392, 10.1016/S0016-5085(75)80025-4 Mitchell, 1976, Isoniazid liver injury: Clinical spectrum, pathology, and probable pathogenesis, Ann Intern Med, 84, 181, 10.7326/0003-4819-84-2-181 Mitchell, 1984, Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2 receptor antagonists in vivo and in vitro in the rat and man, J Clin Invest, 73, 383, 10.1172/JCI111223 Moody, 1985, Immunofluorescent determination of the lobular distribution of a constitutive form of hepatic microsomal cytochrome P-450, Hepatology, 5, 440, 10.1002/hep.1840050317 Morgan, 1984, Impaired oxidation of debrisoquine in patients with perhexiline liver injury, Gut, 25, 1057, 10.1136/gut.25.10.1057 Nebert, 1987, P450 genes and evolutionary genetics, Hosp Prac, 22, 63 Neuberger, 1985, Antibody mediated hepatocyte injury in methyldopa induced hepatotoxicity, Gut, 26, 1233, 10.1136/gut.26.11.1233 Norris, 1989, Genetic and environmental factors that regulate cytosolic epoxide hydrolase activity in normal human lymphocytes, J Clin Invest, 84, 1749, 10.1172/JCI114358 Pohl, 1988, The immunologic and metabolic basis of drug hypersensitivities, Annu Rev Pharmacol, 28, 367, 10.1146/annurev.pa.28.040188.002055 Pohl, 1989, Neoantigens associated with halothane hepatitis, Drug Metab Rev, 20, 203, 10.3109/03602538909103537 Reynolds, 1971, Chronic active hepatitis and lupoid hepatitis caused by a laxative, oxyphenisatin, N Engl J Med, 285, 818, 10.1056/NEJM197110072851501 Rodman, 1976, Methyldopa hepatitis: A report of six cases and review of the literature, Am J Med, 60, 941, 10.1016/0002-9343(76)90564-7 Satoh, 1989, Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroace-tylated carboxyl-esterase, Proc Natl Acad Sci USA, 86, 322, 10.1073/pnas.86.1.322 Seeff, 1986, Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure, Ann Intern Med, 104, 399, 10.7326/0003-4819-104-3-399 Seidegard, 1988, Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion, Proc Natl Acad Sci USA, 85, 7293, 10.1073/pnas.85.19.7293 1984, Serious adverse reactions with sulfonamides, FDA Drug Bull, 14, 5 Shear, 1985, In vitro evaluation of a toxic metabolite of sulfadiazine, Can J Physiol Pharmacol, 63, 1370, 10.1139/y85-225 Shear, 1986, Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity, Ann Intern Med, 105, 179, 10.7326/0003-4819-105-2-179 Sherlock, 1989, Drugs and the liver, 372 Skoda, 1988, Two mutant alleles of the human cytochrome P-450 dbl gene (P450 C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs, Proc Natl Acad Sci USA, 85, 5240, 10.1073/pnas.85.14.5240 Smilkstein, 1988, Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the National Multicenter study (1976 to 1985), N Engl J Med, 319, 1557, 10.1056/NEJM198812153192401 Spielberg, 1980, Acetaminophen toxicity in human lymphocytes in vitro, J Pharmacol Exp Ther, 213, 395 Spielberg, 1981, Glutathione synthetase deficient lymphocytes and acetaminophen toxicity, Clin Pharmacol Ther, 29, 51, 10.1038/clpt.1981.9 Spielberg, 1981, Predisposition to phenytoin hepatotoxicity assessed in vitro, N Engl J Med, 305, 722, 10.1056/NEJM198109243051302 Tirmenstein, 1989, Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3-hydroxyacetanilide, in mouse liver, J Biol Chem, 264, 9814, 10.1016/S0021-9258(18)81731-8 Vergani, 1980, Antibodies to the surface of halothane altered hepatocytes in patients with severe halothane associated hepatitis, N Engl J Med, 303, 66, 10.1056/NEJM198007103030202 Vessell, 1988, Pharmacogenetics, 1213 Waxman, 1988, Antibodies to liver/kidney microsome-1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P450, Gastroenterology, 95, 1326, 10.1016/0016-5085(88)90368-X Zanger, 1988, Antibodies against human cytochrome P-450 dbl in autoimmune hepatitis type II, Proc Natl Acad Sci USA, 85, 8256, 10.1073/pnas.85.21.8256 Zimmerman, 1978 Zimmerman, 1982, Valproate-induced hepatic injury: Analysis of 23 fatal cases, Hepatology, 2, 591, 10.1002/hep.1840020513 Zimmerman, 1984, Ticrynafen-associated hepatic injury: Analysis of 340 cases, Hepatology, 4, 315, 10.1002/hep.1840040223 Zimmerman, 1987, Toxic and drug-induced hepatitis, 591 Zucker, 1990, Chlorpromazine induced immunopathy: Progressive increase in serum IgM, Medicine, 69, 92, 10.1097/00005792-199003000-00003