The Life Cycle of the Uterine Fibroid Myocyte

Current Obstetrics and Gynecology Reports - Tập 7 Số 2 - Trang 97-105 - 2018
Gordon P. Flake1, Alicia B. Moore2, Deloris Sutton1, Norris Flagler1, Natasha P. Clayton1, Grace E. Kissling3, Benita Wicker Hall1, John E. Horton1, David K. Walmer4, Stanley J. Robboy4, Darlene Dixon2
1Cellular and Molecular Pathology Branch, National Toxicology Program (NTP), Department of Health and Human Services, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, 27709, USA
2National Toxicology Program Laboratory (NTPL), National Toxicology Program (NTP), Department of Health and Human Services, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, 27709, USA
3Biostatistics and Computational Biology Branch, National Toxicology Program (NTP), Division of Intramural Research, Department of Health and Human Services, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, 27709, USA
4Duke University Medical Center, Durham, NC 27710, USA

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Tài liệu tham khảo

Peddada SD, Laughlin SK, Miner K, Guyon JP, Haneke K, Vahdat HL, et al. Growth of uterine leiomyomata among premenopausal black and white women. PNAS. 2008;105(50):19887–92.

Moore AB, Flake GP, Swartz CD, Heartwell G, Cousins D, Haseman JK, et al. Association of race, age, and body mass index with gross pathology of uterine fibroids. J Reprod Med. 2008;53:90–6.

• Flake GP, Moore AB, Sutton D, Kissling GE, Horton J, Wicker B, et al. The natural history of uterine leiomyomas: light and electron microscopic studies of fibroid phases, interstitial ischemia, inanosis, and reclamation. Obstet Gynecol Int. 2013;2013:528376. This report details the observations used to develop the concept of fibroid phases, as related to myocyte atrophy, injury, and cell death.

• Flake GP, Moore AB, Flagler N, Wicker B, Clayton N, Kissling GE, et al. The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis. Obstet Gynecol Int. 2013;2013:285103. This report presents the morphometric studies supporting and reinforcing the concepts developed in the light and electron microscopic studies which were reported in [3•].

Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188:100–7.

Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111(8):1037–54.

Stewart EA, Nowak RA. New concepts in the treatment of uterine leiomyomas. Obstet Gynecol. 1998;92:624–7.

Coupey S, editor. Primary care of adolescent girls. Philadelphia, PA: Hanley and Belfus; 2000.

Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Investig. 1983;49:208–15.

Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev. 1995;75:487–517.

Dixon D, Flake GP, Moore AB, He H, Haseman JK, Risinger JI, et al. Cell proliferation and apoptosis in human uterine leiomyomas and myometria. Virchows Arch. 2002;441:53–62.

Hall JE. Guyton and Hall textbook of medical physiology. 12th ed. Philadelphia, PA: Saunders Elsevier; 2011.

Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular biology of the cell. 3rd ed. New York: Garland Publishing; 1994.