The Level of proBDNF in Blood Lymphocytes Is Correlated with that in the Brain of Rats with Photothrombotic Ischemic Stroke

Luo Hy1, Mehreen Rahman2, Larisa Bobrovskaya2, Xin‐Fu Zhou3
1Department of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming, China
2School of Pharmacy and Medical Sciences, Division of Health Sciences, Faculty of Health Sciences, University of South Australia, Adelaide, Australia
3School of Pharmacy and Medical Sciences, Division of Health Sciences, Faculty of Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia

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Alboni S, Tascedda F, Corsini D, Benatti C, Caggia F et al (2011) Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice. Neuropharmacology 60:1337–1346. https://doi.org/10.1016/j.neuropharm.2011.01.050

Allard L, Turck N, Burkhard PR, Walter N, Rosell A et al (2007) Ubiquitin fusion degradation protein 1 as a blood marker for the early diagnosis of ischemic stroke. Biomark Insights 2:155–164

Barker PA (2009) Whither proBDNF? Nat Neurosci 12:105–106. https://doi.org/10.1038/nn0209-105

Béjot Y, Mossiat C, Giroud M, Prigent-Tessier A, Marie C (2011) Circulating and brain BDNF levels in stroke rats. Relevance to clinical studies. PLoS One 6:e29405. https://doi.org/10.1371/journal.pone.0029405

Cui X, Chopp M, Zacharek A, Ning R, Ding X et al (2013) Endothelial nitric oxide synthase regulates white matter changes via the BDNF/TrkB pathway after stroke in mice. PLoS One 8:e80358. https://doi.org/10.1371/journal.pone.0080358

Dambinova SA, Khounteev GA, Izykenova GA, Zavolokov IG, Ilyukhina AY et al (2003) Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem 49:1752–1762

Donnan GA, Fisher M, Macleod M, Davis SM (2008) Stroke. Lancet  Lancet. 2008 May 10;371(9624):1612-23. https://doi.org/10.1016/s0140-6736(08)60694-7

Göb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P et al (2015) Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation. Ann Neurol 77:784–803. https://doi.org/10.1002/ana.24380

Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: a historical overview and future directions. Psychiatry Clin Neurosci 64:341–357. https://doi.org/10.1111/j.1440-1819.2010.02113.x

Hermann DM, Chopp M (2012) Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol 11:369–380. https://doi.org/10.1016/s1474-4422(12)70039-x

Je HS, Yang F, Ji Y, Potluri S, Fu XQ et al (2013) ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions. J Neurosci 33:9957–9962. https://doi.org/10.1523/JNEUROSCI.0163-13.2013

Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C et al (2009) Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 15:192–199. https://doi.org/10.1038/nm.1927

Lim Y, Zhong JH, Zhou XF (2015) Development of mature BDNF-specific sandwich ELISA. J Neurochem 134:75–85. https://doi.org/10.1111/jnc.13108

Luo C, Zhong XL, Zhou FH, Li JY, Zhou P et al (2016) Peripheral brain derived neurotrophic factor precursor regulates pain as an inflammatory mediator. Sci Rep 6:27171. https://doi.org/10.1038/srep27171

Madinier A, Bertrand N, Rodier M, Quirié A, Mossiat C et al (2013) Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF? Neuroscience 231:169–181. https://doi.org/10.1016/j.neuroscience.2012.11.054

Makar TK, Bever CT, Singh IS, Royal W, Sahu SN et al (2009) Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle. J Neuroimmunol 210:40–51. https://doi.org/10.1016/j.jneuroim.2009.02.017

Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K et al (2003) Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 278:43807–43817. https://doi.org/10.1074/jbc.M305841200

Mitre M, Mariga A, Chao MV (2017) Neurotrophin signalling: novel insights into mechanisms and pathophysiology. Clin Sci (Lond) 131:13–23. https://doi.org/10.1042/CS20160044

Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ et al (2001) Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276:12660–12666. https://doi.org/10.1074/jbc.M008104200

Nieswandt B, Kleinschnitz C, Stoll G (2011) Ischaemic stroke: a thrombo-inflammatory disease? J Physiol 589:4115–4123. https://doi.org/10.1113/jphysiol.2011.212886

Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K et al (2004) Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306:487–491. https://doi.org/10.1126/science.1100135

Ploughman M, Windle V, MacLellan CL, White N, Doré JJ et al (2009) Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke 40:1490–1495. https://doi.org/10.1161/STROKEAHA.108.531806

Quirié A, Hervieu M, Garnier P, Demougeot C, Mossiat C et al (2012) Comparative effect of treadmill exercise on mature BDNF production in control versus stroke rats. PLoS One 7:e44218. https://doi.org/10.1371/journal.pone.0044218

Rahman M, Luo H, Sims NR, Bobrovskaya L, Zhou XF (2018) Investigation of mature BDNF and proBDNF signaling in a rat photothrombotic ischemic model. Neurochem Res. https://doi.org/10.1007/s11064-017-2464-9

Schaaf MJ, de Jong J, de Kloet ER, Vreugdenhil E (1998) Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res 813:112–120

Schäbitz WR, Sommer C, Zoder W, Kiessling M, Schwaninger M et al (2000) Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 31:2212–2217

Schmidt A, Hoppen M, Strecker JK, Diederich K, Schäbitz WR et al (2012) Photochemically induced ischemic stroke in rats.  Exp Transl Stroke Med 4(1):13. https://doi.org/10.1186/2040-7378-4-13

Seidah NG, Chretien M (1999) Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 848:45–62

Taylor AR, Gifondorwa DJ, Robinson MB, Strupe JL, Prevette D et al (2012) Motoneuron programmed cell death in response to proBDNF. Dev Neurobiol 72:699–712. https://doi.org/10.1002/dneu.20964

Teche SP, Nuernberg GL, Sordi AO, de Souza LH, Remy L et al (2013) Measurement methods of BDNF levels in major depression: a qualitative systematic review of clinical trials. Psychiatr 84:485–497. https://doi.org/10.1007/s11126-013-9261-7

Teng HK, Teng KK, Lee R, Wright S, Tevar S et al (2005) ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455–5463. https://doi.org/10.1523/JNEUROSCI.5123-04.2005

Vidaurre OG, Gascón S, Deogracias R, Sobrado M, Cuadrado E et al (2012) Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity. Cell Death Dis 3:e256. https://doi.org/10.1038/cddis.2011.143

Vogelgesang A, Grunwald U, Langner S, Jack R, Bröker BM et al (2008) Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke. Stroke 39:237–241. https://doi.org/10.1161/STROKEAHA.107.493635

Zhang J, Geula C, Lu C, Koziel H, Hatcher LM et al (2003) Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp Neurol 183:469–481

Zhang YP, Wang HY, Zhang C, Liu BP, Peng ZL et al (2018) Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1beta in rats. Behav Brain Res 347:436–445. https://doi.org/10.1016/j.bbr.2018.03.033

Zhou L, Xiong J, Lim Y, Ruan Y, Huang C et al (2013) Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord 150:776–784. https://doi.org/10.1016/j.jad.2013.03.002