The Lantibiotic Lacticin 3147 Prevents Systemic Spread ofStaphylococcus aureusin a Murine Infection Model

International Journal of Microbiology - Tập 2012 - Trang 1-6 - 2012
Clare Piper1, Pat G. Casey2,1, Colin Hill2,1, Paul D. Cotter2,3, R. Paul Ross2,3
1Department of Microbiology, University College Cork, College Road, Cork, Ireland
2Alimentary Pharmabiotic Centre, Cork, Ireland
3Food Biosciences Department, Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland

Tóm tắt

The objective of this study was to investigate thein vivoactivity of the lantibiotic lacticin 3147 against the luminescentStaphylococcus aureusstrain Xen 29 using a murine model. Female BALB/c mice (7 weeks old, 17 g) were divided into groups (n=5) and infected with the Xen 29 strain via the intraperitoneal route at a dose of1×106 cfu/animal. After 1.5 hr, the animals were treated subcutaneously with doses of phosphate-buffered saline (PBS; negative control) or lacticin 3147. Luminescent imaging was carried 3 and 5 hours postinfection. Mice were then sacrificed, and the levels ofS. aureusXen 29 in the liver, spleen, and kidneys were quantified. Notably, photoluminescence and culture-based analysis both revealed that lacticin 3147 successfully controlled the systemic spread ofS. aureusin mice thus indicating that lacticin 3147 has potential as a chemotherapeutic agent forin vivoapplications.

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International Journal of Microbiology

Tập 2012

1-6

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