The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1
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Abildayeva, 2006, 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux, J. Biol. Chem., 281, 12799, 10.1074/jbc.M601019200
Aiello, 2003, ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation, Arterioscler. Thromb. Vasc. Biol., 23, 972, 10.1161/01.ATV.0000054661.21499.FB
Assemat, 2005, Overlapping expression patterns of the multiligand endocytic receptors cubilin and megalin in the CNS, sensory organs and developing epithelial of the rodent embryo, Gene Expr. Patterns, 6, 69, 10.1016/j.modgep.2005.04.014
Balazs, 2004, Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood–brain barrier model, J. Neurochem., 89, 939, 10.1111/j.1471-4159.2004.02373.x
Bodzioch, 1999, The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier Disease, Nat. Genet., 22, 347, 10.1038/11914
Bonarek, 2000, Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study, Neuroepidemiology, 19, 141, 10.1159/000026249
Borghini, 1995, Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid, Biochim. Biophys. Acta, 1255, 192, 10.1016/0005-2760(94)00232-N
Brooks-Wilson, 1999, Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency, Nat. Genet., 22, 336, 10.1038/11905
Brunham, 2006, Intestinal ABCA1 directly contributes to HDL biogenesis in vivo, J. Clin. Invest., 116, 1052, 10.1172/JCI27352
Brunham, 2006, Tissue-Specific Induction of Intestinal ABCA1 Expression With a Liver X Receptor Agonist Raises Plasma HDL Cholesterol Levels, Circ. Res., 99, 672, 10.1161/01.RES.0000244014.19589.8e
Burns, 2006, The effects of ABCA1 on cholesterol efflux and Aβ levels in vitro and in vivo, J. Neurochem., 98, 792, 10.1111/j.1471-4159.2006.03925.x
Calkin, 2010, Liver X receptor signaling pathways and atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 30, 513, 10.1161/ATVBAHA.109.191197
Chiba, 1997, Effects of triamcinolone on brain and cerebrospinal fluid apolipoprotein E levels in rats, Life Sci., 60, 1757, 10.1016/S0024-3205(97)00135-5
DeMattos, 2002, Plaque-associated disruption of CSF and plasma amyloid-β (Aβ) equilibrium in a mouse model of Alzheimer's disease, J. Neurochem., 81, 229, 10.1046/j.1471-4159.2002.00889.x
Demeester, 2000, Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin: cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease, J. Lipid Res., 41, 963, 10.1016/S0022-2275(20)32039-3
Dietschy, 2001, Cholesterol metabolism in the brain, Curr. Opin. Lipidol., 12, 105, 10.1097/00041433-200104000-00003
Donkin, 2010, ATP-binding cassette transporter A1 mediates the beneficial effects of the liver-X-receptor agonist GW3965 on object recognition memory and amyloid burden in APP/PS1 mice, J. Biol. Chem., 285, 34144, 10.1074/jbc.M110.108100
Fan, 2009, Greasing the wheels of Aβ clearance in Alzheimer's disease: the role of lipids and apolipoprotein E, Biofactors, 35, 239, 10.1002/biof.37
Fitz, 2010, Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice, J. Neurosci., 30, 6862, 10.1523/JNEUROSCI.1051-10.2010
Fryer, 2005, The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice, J. Biol. Chem., 280, 25754, 10.1074/jbc.M502143200
Fujiyoshi, 2007, 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression, J. Neurochem., 100, 968, 10.1111/j.1471-4159.2006.04240.x
Gentili, 2005, Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression, Matrix Biol., 24, 35, 10.1016/j.matbio.2004.12.003
Grenier, 2007, Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis, Am. J. Physiol. Gastrointest. Liver Physiol., 293, G1178, 10.1152/ajpgi.00295.2007
Hamon, 2000, ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine, Nat. Cell Biol., 2, 399, 10.1038/35017029
Hirsch-Reinshagen, 2005, The absence of ABCA1 decreases soluble apoE levels but does not diminish amyloid deposition in two murine models of Alzheimer's Disease, J. Biol. Chem., 280, 43243, 10.1074/jbc.M508781200
Hirsch-Reinshagen, 2004, Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain, J. Biol. Chem., 279, 41197, 10.1074/jbc.M407962200
Huuskonen, 2006, Liver X receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells, Biochemistry, 45, 15068, 10.1021/bi061378y
Jamroz-Wisniewska, 2007, Liver X receptors (LXRs). Part II: non-lipid effects, role in pathology, and therapeutic implications, Postepy Hig. Med. Dosw., 61, 760
Jankowsky, 2003, Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ-secretase, Hum. Mol. Genet., 13, 159, 10.1093/hmg/ddh019
Jiang, 2008, ApoE promotes the proteolytic degradation of A beta, Neuron, 58, 681, 10.1016/j.neuron.2008.04.010
Karasinska, 2009, Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function, J. Neurosci., 29, 3579, 10.1523/JNEUROSCI.4741-08.2009
Kivipelto, 2002, Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention, CNS Drugs, 16, 435, 10.2165/00023210-200216070-00001
Kivipelto, 2001, Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study, BMJ, 322, 1447, 10.1136/bmj.322.7300.1447
Kivipelto, 2002, Apolipoprotein E ε4 allele, elevated midlife total cholesterol leve, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer Disease, Ann. Intern. Med., 137, 149, 10.7326/0003-4819-137-3-200208060-00006
Kivipelto, 2005, Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease, Arch. Neurol., 62, 1556, 10.1001/archneur.62.10.1556
Koch, 2001, Characterization of four lipoprotein classes in human cerebrospinal fluid, J. Lipid Res., 42, 1143, 10.1016/S0022-2275(20)31605-9
Koldamova, 2010, The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration, Biochim. Biophys. Acta, 180, 824, 10.1016/j.bbalip.2010.02.010
Koldamova, 2005, Lack of ABCA1 considerably decreased brain apoE level and increases amyloid deposition in APP23 mice, J. Biol. Chem., 280, 43224, 10.1074/jbc.M504513200
Koldamova, 2001, Apolipoprotein A1 directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity, Biochemistry, 40, 3553, 10.1021/bi002186k
Ladu, 1998, Nascent astrocyte particles differ from lipoproteins in CSF, J. Neurochem., 70, 2070, 10.1046/j.1471-4159.1998.70052070.x
Lee, 2003, Cultured gallbladder epithelial cells synthesize apolipoproteins A-I and E, Am. J. Physiol. Gastrointest. Liver Physiol., 285, G630, 10.1152/ajpgi.00101.2003
Lee, 2005, HDLs in apoA-I transgenic Abca1 knockout mice are remodelled normally in plasma but are hypercatabolized by the kidney, J. Lipid Res., 46, 2233, 10.1194/jlr.M500179-JLR200
Lefterov, 2007, Expression profiling in APP23 mouse brain: inhibition of A beta amyloidosis and inflammation in response to LXR agonist treatment, Mol. Neurodegener., 22, 2
Lefterov, 2010, Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1E9 mice, J. Biol. Chem., 285, 36945, 10.1074/jbc.M110.127738
Lewis, 2010, Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer's Disease, J. Biol. Chem., 285, 36958, 10.1074/jbc.M110.127829
Liang, 2004, A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes, J. Neurochem., 88, 623, 10.1111/j.1471-4159.2004.02183.x
Linton, 1991, Phenotypes of apoliprotein B and apolipoprotein E after liver transplantation, J. Clin. Invest., 88, 270, 10.1172/JCI115288
Lund-Katz, 2010, High density lipoprotein structure–function and role in reverse cholesterol transport, Subcell. Biochem., 51, 183, 10.1007/978-90-481-8622-8_7
Murphy, 2009, The anti inflammatory effects of high density lipoproteins, Curr. Med. Chem., 16, 667, 10.2174/092986709787458425
Panzenboeck, 2002, ABCA1 and SR-BI are modulators of reverse sterol transport at an in vitro blood–brain barrier constituted of porcine brain capillary endothelial cells, J. Biol. Chem., 277, 42781, 10.1074/jbc.M207601200
Panzenboeck, 2006, Regulatory effects of synthetic liver X receptor and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells, Int. J. Biochem. Cell Biol., 38, 1314, 10.1016/j.biocel.2006.01.013
Pitas, 1987, Lipoproteins and their receptors in the central nervous system, J. Biol. Chem., 262, 14352, 10.1016/S0021-9258(18)47945-8
Riddell, 2007, The LXR agonist TO901317 selectively lowers hippocampal A beta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease, Mol. Cell. Neurosci., 34, 621, 10.1016/j.mcn.2007.01.011
Roher, 2009, Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease, Biomarkers, 14, 493, 10.3109/13547500903108423
Rust, 1999, Tangier Disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1, Nat. Genet., 22, 352, 10.1038/11921
Saito, 1997, Marked increases in concentrations of apolipoproteins in the cerebrospinal fluid of poliovirus-infected macaques: relations between apolipoprotein concentrations and severity of brain injury, Biochem. J., 321, 145, 10.1042/bj3210145
Sato, 2008, LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels, Lipids, 43, 125, 10.1007/s11745-007-3131-8
Song, 1997, Cerebrospinal fluid apoE and apoA-I concentrations in early- and late-onset Alzheimer's disease, Neurosci. Lett., 231, 175, 10.1016/S0304-3940(97)00558-2
Song, 1998, ApoA-I and apoE concentrations in cerebrospinal fluids of patients with acute meningitis, Ann. Clin. Biochem., 35, 408, 10.1177/000456329803500310
Sovic, 2005, Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood–brain barrier, J. Neurochem., 94, 109, 10.1111/j.1471-4159.2005.03175.x
Suon, 2010, Systemic treatment with liver X receptor agonists raises apolipoproteinE, cholesterol, and amyloid-B peptides in the cerebral spinal fluid of rats, Mol. Neurodegener., 5, 10.1186/1750-1326-5-44
Tall, 2000, Tangier disease as a test of the reverse cholesterol transport hypothesis, J. Clin. Invest., 106, 1263, 10.1172/JCI11538
Terwel, 2011, Critical role of astroglial apolipoprotein E and liver X receptor-{alpha} expression for microglial A{beta} phagocytosis, J. Neurosci., 31, 7049, 10.1523/JNEUROSCI.6546-10.2011
Vanmierlo, 2011, Liver X receptor activation restores memory in aged AD mice without reducing amyloid, Neurobiol. Aging, 32, 1262, 10.1016/j.neurobiolaging.2009.07.005
Wahrle, 2005, Deletion of Abca1 increases A beta deposition in the PDAPP transgenic mouse model of Alzheimer disease, J. Biol. Chem., 280, 43236, 10.1074/jbc.M508780200
Wahrle, 2008, Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease, J. Clin. Invest., 118, 671
Wahrle, 2004, ABCA1 is required for normal CNS apoE levels and for lipidation of astrocyte-secreted apoE, J. Biol. Chem., 279, 40987, 10.1074/jbc.M407963200
Wójcicka, 2007, Liver X receptors (LXRs). Part 1: structure, function, regulation of activity, and role in lipid metabolism, Postepy Hig. Med. Dosw., 61, 736