The Influence of Rapid Onsite Evaluation on the Adequacy Rate of Fine-Needle Aspiration Cytology

American Journal of Clinical Pathology - Tập 139 Số 3 - Trang 300-308 - 2013
Robert L. Schmidt1, Benjamin L. Witt1, Leslie E. Lopez-Calderon1, Lester J. Layfield1
1Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT

Tóm tắt

Abstract

Rapid onsite evaluation (ROSE) has the potential to improve the adequacy rates of fine-needle aspiration (FNA) cytology. Studies have obtained variable results on the influence of ROSE. We conducted a systematic review and meta-analysis of studies on the influence of ROSE on FNA adequacy. We synthesized evidence across all anatomic locations. We only included studies that contained a control arm and compared cohorts with ROSE against cohorts without ROSE at a single location. We screened 2,179 studies and identified 25 studies that met our inclusion criteria. On average, ROSE improves the adequacy rate by 12%, but there was considerable variability across studies. The adequacy rate with ROSE depends on the non-ROSE adequacy rate. Sixty-five percent of the variability in the adequacy rate with ROSE was found to occur because of differences in the adequacy rate without ROSE. Studies with high non-ROSE adequacy rates showed low improvement after ROSE was implemented. Studies must account for the effect of the non-ROSE adequacy rate to determine the effect of ROSE on FNA adequacy rates.

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