Ảnh hưởng của Giới tính và Tuổi tác đến Phản xạ Đường hô hấp trên

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001;163:608–13. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177:1006–14. Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 1998; 157: 144–148. Haponik EF, Smith PL, Bohlman ME, Allen RP, Goldman SM, Bleecker ER. Computerized tomography in obstructive sleep apnea. Correlation of airway size with physiology during sleep and wakefulness. Am Rev Respir Dis. 1983;127:221–6. Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender. Am J Respir Crit Care Med. 2000;162:1627–32. Trinder J, Kay A, Kleiman J, Dunai J. Gender differences in airway resistance during sleep. J Appl Physiol. 1997;83:1986–97. Rowley JA, Zhou X, Vergine I, Shkoukani MA, Badr MS. Influence of gender on upper airway mechanics: upper airway resistance and Pcrit. J Appl Physiol. 2001;91:2248–54. Brown IG, Zamel N, Hoffstein V. Pharyngeal cross-sectional area in normal men and women. J Appl Physiol. 1986;61:890–5. Brooks LJ, Strohl KP. Size and mechanical properties of the pharynx in healthy men and women. Am Rev Respir Dis. 1992;146:1394–7. Martin SE, Mathur R, Marshall I, Douglas NJ. The effect of age, sex, obesity and posture on upper airway size. Eur Respir J. 1997;10:2087–90. Rowley JA, Sanders CS, Zahn BR, Badr MS. Gender differences in upper airway compliance during NREM sleep: role of neck circumference. J Appl Physiol. 2002;92:2535–41. Browne HA, Adams L, Simonds AK, Morrell MJ. Impact of age on breathing and resistive pressure in people with and without sleep apnea. J Appl Physiol. 2001;90:1074–82. Thurnheer R, Wraith PK, Douglas NJ. Influence of age and gender on upper airway resistance in NREM and REM sleep. J Appl Physiol. 2001;90:981–8. Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, et al. The influence of aging on pharyngeal collapsibility during sleep. Chest. 2007;131:1702–9. Mayer P, Pepin JL, Bettega G, Veale D, Ferretti G, Deschaux C, et al. Relationship between body mass index, age and upper airway measurements in snorers and sleep apnoea patients. Eur Respir J. 1996;9:1801–9. • Carlisle T, Carthy ER, Glasser M, Drivas P, McMillan A, Cowie MR, et al. Upper airway factors that protect against obstructive sleep apnoea in healthy older males. Eur Respir J. 2014;44:685–93 Study investigated differences in MRI and acoustic reflectance measurements of the upper airway, finding larger pharyngeal caliber and volume in older males. Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, et al. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse. Am J Med. 2006;119:72–14. Kirkness JP, Schwartz AR, Schneider H, Punjabi NM, Maly JJ, Laffan AM, et al. Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep. J Appl Physiol. 2008;104:1618–24. Patil SP, Schneider H, Marx JJ, Gladmon E, Schwartz AR, Smith PL. Neuromechanical control of upper airway patency during sleep. J Appl Physiol. 2007;102:547–56. Tangel DJ, Mezzanotte WS, White DP. Influences of NREM sleep on activity of palatoglossus and levator palatini muscles in normal men. J Appl Physiol. 1995;78:689–95. Tangel DJ, Mezzanotte WS, White DP. Influence of sleep on tensor palatini EMG and upper airway resistance in normal men. J Appl Physiol. 1991;70:2574–81. Wiegand DA, Latz B, Zwillich CW, Wiegand L. Geniohyoid muscle activity in normal men during wakefulness and sleep. J Appl Physiol. 1990;69:1262–9. Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. Chest. 2009;135:957–64. Wiegand L, Zwillich CW, Wiegand D, White DP. Changes in upper airway muscle activation and ventilation during phasic REM sleep in normal men. J Appl Physiol. 1991;71:488–97. Popovic RM, White DP. Influence of gender on waking genioglossal electromyogram and upper airway resistance. Am J Respir Crit Care Med. 1995;152:725–31. Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol. 1998;84:1055–62. Jordan AS, Catcheside PG, O'Donoghue FJ, Saunders NA, McEvoy RD. Genioglossus muscle activity at rest and in response to brief hypoxia in healthy men and women. J Appl Physiol (1985). 2002;92:410–7. Pae EK, Blasius JJ, Nanda R. Sex differences in genioglossus muscle response to changes in pharyngeal resistance. Am J Orthod Dentofac Orthop. 2002;122:500–5. Horner RL, Innes JA, Holden HB, Guz A. Afferent pathway(s) for pharyngeal dilator reflex to negative pressure in man: a study using upper airway anaesthesia. J Physiol. 1991;436:31–44. Wheatley JR, Mezzanotte WS, Tangel DJ, White DP. Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am Rev Respir Dis. 1993;148:597–605. Wheatley JR, Tangel DJ, Mezzanotte WS, White DP. Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway. J Appl Physiol. 1993;75:2117–24. Horner RL, Innes JA, Murphy K, Guz A. Evidence for reflex upper airway dilator muscle activation by sudden negative airway pressure in man. J Physiol. 1991;436:15–29. Shea SA, Edwards JK, White DP. Effect of wake-sleep transitions and rapid eye movement sleep on pharyngeal muscle response to negative pressure in humans. J Physiol. 1999;520(Pt 3):897–908. White DP, Edwards JK, Shea SA. Local reflex mechanisms: influence on basal genioglossal muscle activation in normal subjects. Sleep. 1998;21:719–28. Fogel RB, White DP, Pierce RJ, Malhotra A, Edwards JK, Dunai J, et al. Control of upper airway muscle activity in younger versus older men during sleep onset. J Physiol. 2003;553:533–44. Saboisky JP, Stashuk DW, Hamilton-Wright A, Carusona AL, Campana LM, Trinder J, et al. Neurogenic changes in the upper airway of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2012;185:322–9. • Saboisky JP, Stashuk DW, Hamilton-Wright A, Trinder J, Nandedkar S, Malhotra A. Correction: effects of aging on genioglossus motor units in human. PLoS One. 2016;11:e0164252 Studying the motor unit potential of the genioglossal muscle, authors show that older men have more neurogenic changes than younger men; these neurogenic changes are similar to those seen in subjects with OSA, suggesting that they may contribute to impair upper airway neuromuscular activity in older men. Klawe JJ, Tafil-Klawe M. Age-related response of the genioglossus muscle EMG-activity to hypoxia in humans. J Physiol Pharmacol. 2003;54(Suppl 1):14–9. • Murtolahti S, Crouse UK, Pahkala R, Warren DW, Laine-Alava MT. Perception and respiratory responses of the upper airway mechanism to added resistance with aging. Laryngoscope Investig Otolaryngol. 2017;2:417–22 Study confirms that older subjects have impaired perception of the pressure changes associated with inspiratory loading; this finding is consistent with others that upper airway reflexes are impaired with aging.