The Impact of Sex on Alloimmunity

Beery, 2011, Sex bias in neuroscience and biomedical research, Neurosci. Biobehav. Rev., 35, 565, 10.1016/j.neubiorev.2010.07.002 Kim, 2009, H-Y incompatibility predicts short-term outcomes for kidney transplant recipients, J. Am. Soc. Nephrol., 20, 2025, 10.1681/ASN.2008101110 Gratwohl, 2008, H-Y as a minor histocompatibility antigen in kidney transplantation: a retrospective cohort study, Lancet, 372, 49, 10.1016/S0140-6736(08)60992-7 Zeier, 2002, The effect of donor gender on graft survival, J. Am. Soc. Nephrol., 13, 2570, 10.1097/01.ASN.0000030078.74889.69 Brenner, 1993, Nephron underdosing: a programmed cause of chronic renal allograft failure, Am. J. Kidney Dis., 21, 66, 10.1016/0272-6386(93)70097-I Hayes, 1991, The development of proteinuria and focal-segmental glomerulosclerosis in recipients of pediatric donor kidneys, Transplantation, 52, 813, 10.1097/00007890-199111000-00011 Brenner, 1992, In renal transplantation, one size may not fit all, J. Am. Soc. Nephrol., 3, 162, 10.1681/ASN.V32162 Tan, 2012, Donor–recipient sex mismatch in kidney transplantation, Gend. Med., 9, 335, 10.1016/j.genm.2012.07.004 Lepeytre, 2017, Association of sex with risk of kidney graft failure differs by age, J. Am. Soc. Nephrol., 28, 3014, 10.1681/ASN.2016121380 Neugarten, 1994, The impact of gender on renal transplantation, Transplantation, 58, 1145 Pugliese, 2005, Kidney graft survival in Italy and factors influencing it, Prog. Transplant., 15, 385, 10.1177/152692480501500411 Weiss, 2009, The impact of donor-recipient sex matching on survival after orthotopic heart transplantation: analysis of 18000 transplants in the modern era, Circ. Heart Fail., 2, 401, 10.1161/CIRCHEARTFAILURE.108.844183 Kaczmarek, 2013, Gender does matter: gender-specific outcome analysis of 67,855 heart transplants, Thorac. Cardiovasc. Surg., 61, 29 Khush, 2012, Influence of donor and recipient sex mismatch on heart transplant outcomes: analysis of the International Society for Heart and Lung Transplantation Registry, J. Heart Lung Transplant., 31, 459, 10.1016/j.healun.2012.02.005 Reed, 2014, Cardiac size and sex-matching in heart transplantation: size matters in matters of sex and the heart, JACC Heart Fail., 2, 73, 10.1016/j.jchf.2013.09.005 Martinez-Selles, 2015, Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry, Transpl. Int., 28, 305, 10.1111/tri.12488 Schoening, 2000, Gender matches in liver transplant allocation: matched and mismatched male-female donor-recipient combinations; long-term follow-up of more than patients at a single center, Exp. Clin. Transplant., 14, 184 Meier-Kriesche, 2001, Gender differences in the risk for chronic renal allograft failure, Transplantation, 71, 429, 10.1097/00007890-200102150-00016 Goulmy, 1996, Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation, N. Engl. J. Med., 334, 281, 10.1056/NEJM199602013340501 Tan, 2008, H-Y antibody development associates with acute rejection in female patients with male kidney transplants, Transplantation, 86, 75, 10.1097/TP.0b013e31817352b9 Tullius, 2010, The combination of donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome, Ann. Surg., 252, 662, 10.1097/SLA.0b013e3181f65c7d Blume, 2014, Pregnancies in liver and kidney transplant recipients: a review of the current literature and recommendation, Best Pract. Res. Clin. Obstet. Gynaecol., 28, 1123, 10.1016/j.bpobgyn.2014.07.021 Hebral, 2014, Pregnancy after kidney transplantation: outcome and anti-human leucocyte antigen alloimmunization risk, Nephrol. Dial. Transplant, 29, 1786, 10.1093/ndt/gfu208 Cheung, 2013, Renal physiology of pregnancy, Adv. Chronic Kidney Dis., 20, 209, 10.1053/j.ackd.2013.01.012 Libert, 2010, The X chromosome in immune functions: when a chromosome makes the difference, Nat. Rev. Immunol., 10, 594, 10.1038/nri2815 Carrel, 2005, X-inactivation profile reveals extensive variability in X-linked gene expression in females, Nature, 434, 400, 10.1038/nature03479 Tukiainen, 2017, Landscape of X chromosome inactivation across human tissues, Nature, 550, 244, 10.1038/nature24265 Klein, 2016, Sex differences in immune responses, Nat Rev. Immunol., 16, 626, 10.1038/nri.2016.90 Moretti, 2017, SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation, Cell Death Differ., 24, 1029, 10.1038/cdd.2017.32 Dreumont, 2010, Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2β, J. Cell Sci., 123, 40, 10.1242/jcs.055889 Case, 2013, The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease, Genome Res., 23, 1474, 10.1101/gr.156703.113 Teuscher, 2006, Evidence that the Y chromosome influences autoimmune disease in male and female mice, Proc. Natl. Acad. Sci. U. S. A., 103, 8024, 10.1073/pnas.0600536103 Krementsov, 2017, Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection, Proc. Natl. Acad. Sci. U. S. A., 114, 3491, 10.1073/pnas.1620889114 Walport, 2014, Human UTY(KDM6C) is a male-specific N-methyl lysyl demethylase, J. Biol. Chem., 289, 18302, 10.1074/jbc.M114.555052 Lee, 2007, Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein, Cell, 128, 877, 10.1016/j.cell.2007.02.004 Halter, 2017 Hoffman, 2016 Corton, 2014 Alegre, 2008, The multiple facets of Toll-like receptors in transplantation biology, Transplantation, 86, 1, 10.1097/TP.0b013e31817c11e6 Ono, 2005, Sex differences in cytokine production and surface antigen expression of peripheral blood mononuclear cells after surgery, Am. J. Surg., 190, 439, 10.1016/j.amjsurg.2005.03.031 Temple, 2008, Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4, Cell Immunol., 251, 69, 10.1016/j.cellimm.2008.04.013 Marriott, 2006, Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: a possible mechanism for gender-based differences in endotoxic shock susceptibility, J. Reprod. Immunol., 71, 12, 10.1016/j.jri.2006.01.004 Rettew, 2009, Estrogens augment cell surface TLR4 expression on murine macrophages and regulate sepsis susceptibility in vivo, Endocrinology, 150, 3877, 10.1210/en.2009-0098 Calippe, 2010, 17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo, J. Immunol., 185, 1169, 10.4049/jimmunol.0902383 Rettew, 2008, Testosterone reduces macrophage expression in the mouse of Toll-like receptor 4, a trigger for inflammation and innate immunity, Biol. Reprod., 78, 432, 10.1095/biolreprod.107.063545 Paharkova-Vatchkova, 2004, Estrogen preferentially promotes the differentiation of CD11c+ CD11b(intermediate) dendritic cells from bone marrow precursors, J. Immunol., 172, 1426, 10.4049/jimmunol.172.3.1426 Siracusa, 2008, 17beta-estradiol alters the activity of conventional and IFN-producing killer dendritic cells, J. Immunol., 180, 1423, 10.4049/jimmunol.180.3.1423 Xiu, 2016, High physiological concentrations of progesterone reverse estradiol-mediated changes in differentiation and functions of bone marrow derived dendritic cells, PLoS One, 11, 10.1371/journal.pone.0153304 Bengtsson, 2004, 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells, Blood, 104, 1404, 10.1182/blood-2003-10-3380 Cunningham, 2016, Early ovariectomy results in reduced numbers of CD11c+/CD11b+ spleen cells and impacts disease expression in murine lupus, Front. Immunol., 7, 31, 10.3389/fimmu.2016.00031 Cunningham, 2012, Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus, Clin. Immunol., 144, 1, 10.1016/j.clim.2012.04.001 Nalbandian, 2005, The selective estrogen receptor modulators, tamoxifen and raloxifene, impair dendritic cell differentiation and activation, J. Immunol., 175, 2666, 10.4049/jimmunol.175.4.2666 Jones, 2010, Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone, J. Immunol., 185, 4525, 10.4049/jimmunol.0901155 Xu, 2011, Immunosuppressive effect of progesterone on dendritic cells in mice, J. Reprod. Immunol., 91, 17 Eichwald, 1955, Skin, Transplant. Bull., 2, 148 Spierings, 2003, Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation, Lancet, 362, 610, 10.1016/S0140-6736(03)14191-8 Vogt, 2000, DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection, Blood, 95, 1100, 10.1182/blood.V95.3.1100.003k42_1100_1105 Scott, 1995, Identification of a mouse male-specific transplantation antigen, H-Y, Nature, 376, 695, 10.1038/376695a0 Vogt, 2002, The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease, Blood, 99, 3027, 10.1182/blood.V99.8.3027 Vogt, 2000, UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition, Blood, 96, 3126, 10.1182/blood.V96.9.3126 Torikai, 2004, A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene, J. Immunol., 173, 7046, 10.4049/jimmunol.173.11.7046 Zorn, 2004, Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation, J. Exp. Med., 199, 1133, 10.1084/jem.20031560 Wagner, 2012, H-Y antigen in kidney transplant: does gender matter?, Gend. Med., 9, 387, 10.1016/j.genm.2012.08.002 Russell, 2011, Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts, Transplantation, 91, 847, 10.1097/TP.0b013e3182122f82 Strom, 1996, The Th1/Th2 paradigm and the allograft response, Curr. Opin. Immunol., 8, 688, 10.1016/S0952-7915(96)80087-2 Weinstein, 1984, Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse, J. Immunol., 132, 656, 10.4049/jimmunol.132.2.656 Pelfrey, 2002, Sex differences in cytokine responses to myelin peptides in multiple sclerosis, J. Neuroimmunol., 130, 211, 10.1016/S0165-5728(02)00224-2 Hewagama, 2009, Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis, Genes Immun., 10, 509, 10.1038/gene.2009.12 Giron-Gonzalez, 2000, Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women, Eur. J. Endocrinol., 143, 31, 10.1530/eje.0.1430031 Palaszynski, 2005, A Yin-Yang effect between sex chromosome complement and sex hormones on the immune response, Endocrinology, 146, 3280, 10.1210/en.2005-0284 Smith-Bouvier, 2008, A role for sex chromosome complement in the female bias in autoimmune disease, J. Exp. Med., 205, 1099, 10.1084/jem.20070850 Hall, 1985, Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells, J. Exp. Med., 162, 1683, 10.1084/jem.162.5.1683 Kahn, 2010, Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance, Proc. Natl. Acad. Sci. U. S. A., 107, 9299, 10.1073/pnas.1003909107 Haghmorad, 2014, Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in both ovariectomized and pregnant C57BL/6 mice through expansion of Treg and Th2 cells, J. Neuroimmunol., 277, 85, 10.1016/j.jneuroim.2014.10.004 Floess, 2007, Epigenetic control of the Foxp3 locus in regulatory T cells, PLoS Biol., 5, 10.1371/journal.pbio.0050038 Zheng, 2010, Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate, Nature, 463, 808, 10.1038/nature08750 Valenzuela, 2017, Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies, J. Clin. Invest., 127, 2492, 10.1172/JCI90597 Medina, 2000, Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors, Blood, 95, 2059, 10.1182/blood.V95.6.2059 Grimaldi, 2002, Estrogen alters thresholds for B cell apoptosis and activation, J. Clin. Invest., 109, 1625, 10.1172/JCI0214873 Paavonen, 1981, Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures, J. Exp. Med., 154, 1935, 10.1084/jem.154.6.1935 Ellis, 2001, Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice, Int. Immunol., 13, 553, 10.1093/intimm/13.4.553 Brody, 1983, Peripheral hormone levels and the endometrial condition in postmenopausal women, Acta. Obstet. Gynecol. Scand., 62, 525, 10.3109/00016348309154230 Simpson, 1987, Separation of the genetic loci for the H-Y antigen and for testis determination on human Y chromosome, Nature, 326, 876, 10.1038/326876a0 Kissick, 2014, Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation, Proc Natl Acad. Sci. U. S. A., 111, 9887, 10.1073/pnas.1402468111