The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice

Abbott, 2018, Is ‘friendly fire’ in the brain provoking alzheimer’s disease?, Nature, 556, 426, 10.1038/d41586-018-04930-7

2012, 2012 Alzheimer’s disease facts and figures., Alzheimers Dement., 8, 131, 10.1016/j.jalz.2012.02.001

Banks, 2010, Minimal penetration of lipopolysaccharide across the murine blood-brain barrier., Brain Behav. Immun., 24, 102, 10.1016/j.bbi.2009.09.001

Bialas, 2013, TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement., Nat. Neurosci., 16, 1773, 10.1038/nn.3560

Bu, 2018, Blood-derived amyloid-β protein induces alzheimer’s disease pathologies., Mol. Psychiatry, 23, 1, 10.1038/mp.2017.204

Bu, 2015, A study on the association between infectious burden and alzheimer’s disease., Eur. J. Neurol., 22, 1519, 10.1111/ene.12477

Burns, 2009, Alzheimer’s disease., BMJ, 338, 10.1136/bmj.b158

Cunningham, 2005, Central and Systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration., J. Neurosci., 40, 9275, 10.1523/JNEUROSCI.2614-05.2005

Dominy, 2019, Porphyromonas gingivalis in alzheimer’s disease brains: evidence for disease causation and treatment with small-molecule inhibitors., Sci. Adv., 5, 10.1126/sciadv.aau3333

Dubois, 2007, Research criteria for the diagnosis of alzheimer’s disease: revising the NINCDS-ADRDA criteria., Lancet Neurol., 6, 734, 10.1016/S1474-4422(07)701783

Evin, 2003, Proteolytic processing of the Alzheimer’s disease amyloid precursor protein in brain and platelets., J. Neurosci. Res., 74, 386, 10.1002/jnr.10745

Fraser, 2010, C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production., J. Neurochem., 112, 733, 10.1111/j.1471-4159.2009.06494.x

Gotz, 2008, Animal models of Alzheimer’s disease and frontotemporal dementia., Nat. Rev. Neurosci., 9, 532, 10.1038/nrn2420

Hebert, 2003, Alzheimer’s disease in the US population., Arch. Neurol., 60, 1119, 10.1001/archneur.60.8.1119

Hong, 2016, Complement and microglia mediate early synapse loss in alzheimer mouse models., Science, 352, 712, 10.1126/science.aad8373

Ippolito, 2010, Quantifying synapses: an immunocytochemistry-based assay to quantify synapse number., J. Vis. Exp., 45, 10.3791/2270

Joachim, 1989, Diffuse senile plaques occur commonly in the cerebellum in alzheimer’s disease., Am. J. Pathol., 135, 309

Kumar, 2016, Amyloid-β peptide protects against microbial infection in mouse and worm models of alzheimer’s disease., Sci. Transl. Med., 8, 340, 10.1126/scitranslmed.aaf1059

Lee, 2008, Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation., J Neuroinflamm., 5, 10.1186/1742-2094-5-37

Maheshwari, 2015, Bacterial infection and Alzheimer’s disease: a meta-analysis., J. Alzheimers Dis., 43, 957, 10.3233/JAD-140621

Morris, 1984, Developments of a water-maze procedure for studying spatial learning in the rat., J. Neurosci. Methods, 11, 47, 10.1016/0165-0270(84)90007-4

Nauta, 2003, Recognition and clearance of apoptotic cells: a role for complement and pentraxins., Trends. Immunol., 24, 148, 10.1016/s1471-4906(03)00030-9

Pan, 2002, TNF alpha transport across the blood-brain barrier is abolished in receptor knockout mice., Exp. Neurol., 174, 193, 10.1006/exnr.2002.7871

Radde, 2008, The value of incomplete mouse models of Alzheimer’s disease., Eur. J. Nucl. Med. Mol. Imaging, 35, S70, 10.1007/s00259-007-0704-y

Readhead, 2018, Multiscale analysis of independent alzheimer’s cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus., Neuron, 99, 64, 10.1016/j.neuron.2018.05.023

Salter, 2017, Microglia emerge as central players in brain disease., Nat. Med., 23, 1018, 10.1038/nm.4397

Schafer, 2012, Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner., Neuron, 74, 691, 10.1016/j.neuron.2012.03.026

Selkoe, 2002, Alzheimer’s disease is a synaptic failure., Science, 298, 789, 10.1126/science.1074069

Stevens, 2007, The classical complement cascade mediates CNS synapse elimination., Cell, 131, 1164, 10.1016/j.cell.2007.10.036

Terry, 1991, Physical basis of cognitive alterations in alzheimer’s disease: synapse loss is the major correlate of cognitive impairment., Ann. Neurol., 30, 572, 10.1002/ana.410300410

Veerhuis, 2011, Complement in the brain., Mol. Immunol., 48, 1592, 10.1016/j.molimm.2011.04.003

Vorhees, 2006, Morris water maze: procedures for assessing spatial and related forms of learning and memory., Nat. Protoc., 1, 848, 10.1038/nprot.2006.116

Wallin, 2012, Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study., J. Alzheimers. Dis., 31, 669, 10.3233/JAD-2012-111736

Wu, 2019, Microglia and amyloid precursor protein coordinate control of transient candida cerebritis with memory deficits., Nat. Commun., 10, 10.1038/s41467-018-07991-4

Zakaria, 2017, Lipopolysaccharide-induced memory impairment in rats: a model of alzheimer’s disease., Physiol. Res., 66, 553, 10.1155/2018/9318789