The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging
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Stevens, 2012, National, regional, and global trends in adult overweight and obesity prevalences, Popul Health Metr., 10, 22, 10.1186/1478-7954-10-22
Kelly, 2008, Global burden of obesity in 2005 and projections to 2030, Int J Obes, 32, 1431, 10.1038/ijo.2008.102
Hruby, 2015, The epidemiology of obesity: a big picture, Pharmacoeconomics, 33, 673, 10.1007/s40273-014-0243-x
Esser, 2014, Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes, Diabetes Res Clin Pract, 105, 141, 10.1016/j.diabres.2014.04.006
Birkenfeld, 2014, Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes, Hepatology, 59, 713, 10.1002/hep.26672
Wilson, 2005, Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus, Circulation, 112, 3066, 10.1161/CIRCULATIONAHA.105.539528
Bonomini, 2015, Metabolic syndrome, aging and involvement of oxidative stress, Aging Dis, 6, 109, 10.14336/AD.2014.0305
Lutz, 2008, The coming acceleration of global population ageing, Nature, 451, 716, 10.1038/nature06516
Goronzy, 2013, Understanding immunosenescence to improve responses to vaccines, Nat Immunol, 14, 428, 10.1038/ni.2588
Frasca, 2017, Aging, obesity, and inflammatory age-related diseases, Front Immunol, 8, 1745, 10.3389/fimmu.2017.01745
Wronska, 2012, Structural and biochemical characteristics of various white adipose tissue depots, Acta Physiol, 205, 194, 10.1111/j.1748-1716.2012.02409.x
Ibrahim, 2010, Subcutaneous and visceral adipose tissue: structural and functional differences, Obes Rev, 11, 11, 10.1111/j.1467-789X.2009.00623.x
Chusyd, 2016, Relationships between rodent white adipose fat pads and human white adipose fat depots, Front Nutr, 3, 10, 10.3389/fnut.2016.00010
Divoux, 2011, Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue, Obes Rev, 12, e494, 10.1111/j.1467-789X.2010.00811.x
Bora, 2017, Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation, Stem Cell Res Ther, 8, 145, 10.1186/s13287-017-0598-y
Tholpady, 2006, Adipose tissue: stem cells and beyond, Clin Plast Surg, 33, 55, 10.1016/j.cps.2005.08.004
Halberg, 2009, Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue, Mol Cell Biol, 29, 4467, 10.1128/MCB.00192-09
Berger, 1999, Effect of diet on fat cell size and hormone-sensitive lipase activity, J Appl Physiol, 87, 227, 10.1152/jappl.1999.87.1.227
Hotamisligil, 1993, Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance, Science, 259, 87, 10.1126/science.7678183
Copps, 2012, Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2, Diabetologia, 55, 2565, 10.1007/s00125-012-2644-8
Tanti, 2012, Implication of inflammatory signaling pathways in obesity-induced insulin resistance, Front Endocrinol, 3, 181, 10.3389/fendo.2012.00181
Khan, 2009, Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI, Mol Cell Biol, 29, 1575, 10.1128/MCB.01300-08
Nakajima, 2002, Positive effect of collagen V and VI on triglyceride accumulation during differentiation in cultures of bovine intramuscular adipocytes, Differentiation, 70, 84, 10.1046/j.1432-0436.2002.700203.x
Hasegawa, 2018, Repression of adipose tissue fibrosis through a PRDM16-GTF2IRD1 complex improves systemic glucose homeostasis, Cell Metab, 27, 180, 10.1016/j.cmet.2017.12.005
O'Hara, 2009, Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium, Pflugers Arch, 458, 1103, 10.1007/s00424-009-0693-8
Tchkonia, 2010, Fat tissue, aging, and cellular senescence, Aging Cell, 9, 667, 10.1111/j.1474-9726.2010.00608.x
Xu, 2015, JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age, Proc Natl Acad Sci USA, 112, E6301, 10.1073/pnas.1515386112
Wernstedt Asterholm, 2014, Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling, Cell Metab, 20, 103, 10.1016/j.cmet.2014.05.005
Xue, 2014, Transcriptome-based network analysis reveals a spectrum model of human macrophage activation, Immunity, 40, 274, 10.1016/j.immuni.2014.01.006
Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 112, 1796, 10.1172/JCI200319246
Lumeng, 2007, Obesity induces a phenotypic switch in adipose tissue macrophage polarization, J Clin Invest, 117, 175, 10.1172/JCI29881
Odegaard, 2007, Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance, Nature, 447, 1116, 10.1038/nature05894
Hassnain Waqas, 2017, Adipose tissue macrophages develop from bone marrow-independent progenitors in, J Leukoc Biol, 102, 845, 10.1189/jlb.1A0317-082RR
Lumeng, 2007, Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity, Diabetes, 56, 16, 10.2337/db06-1076
Jang, 2016, Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis, Diabetes, 65, 2516, 10.2337/db15-1624
Boutens, 2018, Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses, Diabetologia, 61, 942, 10.1007/s00125-017-4526-6
Jha, 2015, Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization, Immunity, 42, 419, 10.1016/j.immuni.2015.02.005
Morris, 2013, Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice, Diabetes, 62, 2762, 10.2337/db12-1404
Cinti, 2005, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J Lipid Res, 46, 2347, 10.1194/jlr.M500294-JLR200
Kanda, 2006, MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, J Clin Invest, 116, 1494, 10.1172/JCI26498
Amano, 2014, Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation, Cell Metab, 19, 162, 10.1016/j.cmet.2013.11.017
Nomiyama, 2007, Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice, J Clin Invest, 117, 2877, 10.1172/JCI31986
Allman, 2015, TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection, Proc Natl Acad Sci USA, 112, E4094, 10.1073/pnas.1421580112
Liu, 2018, TACI-Deficient macrophages protect mice against metaflammation and obesity-induced dysregulation of glucose homeostasis, Diabetes, 67, 1589, 10.2337/db17-1089
Spadaro, 2017, IGF1 shapes macrophage activation in response to immunometabolic challenge, Cell Rep, 19, 225, 10.1016/j.celrep.2017.03.046
Martinez, 2014, The M1 and M2 paradigm of macrophage activation: time for reassessment, F1000Prime Rep, 6, 13, 10.12703/P6-13
Russo, 2018, Properties and functions of adipose tissue macrophages in obesity, Immunology, 155, 407, 10.1111/imm.13002
Bertola, 2012, Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients, Diabetes, 61, 2238, 10.2337/db11-1274
Jaitin, 2019, Lipid-associated macrophages control metabolic homeostasis in a trem2-dependent manner, Cell, 178, 686, 10.1016/j.cell.2019.05.054
Kratz, 2014, Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages, Cell Metab, 20, 614, 10.1016/j.cmet.2014.08.010
Hill, 2018, Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue, Proc Natl Acad Sci USA, 115, E5096, 10.1073/pnas.1802611115
Pirzgalska, 2017, Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine, Nat Med, 23, 1309, 10.1038/nm.4422
Lumeng, 2011, Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue, J Immunol, 187, 6208, 10.4049/jimmunol.1102188
Camell, 2017, Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature, 550, 119, 10.1038/nature24022
Camell, 2019, Aging induces an Nlrp3 inflammasome-dependent expansion of adipose B cells that impairs metabolic homeostasis, Cell Metab, 30, 1024, 10.1016/j.cmet.2019.10.006
Diefenbach, 2014, Development, differentiation, and diversity of innate lymphoid cells, Immunity, 41, 354, 10.1016/j.immuni.2014.09.005
Yudanin, 2019, Spatial and temporal mapping of human innate lymphoid cells reveals elements of tissue specificity, Immunity, 50, 505, 10.1016/j.immuni.2019.01.012
Fuchs, 2016, ILC1s in tissue inflammation and infection, Front Immunol, 7, 104, 10.3389/fimmu.2016.00104
O'Sullivan, 2016, Adipose-resident group 1 innate lymphoid cells promote obesity-associated insulin resistance, Immunity, 45, 428, 10.1016/j.immuni.2016.06.016
Boulenouar, 2017, Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity, Immunity, 46, 273, 10.1016/j.immuni.2017.01.008
Kim, 2015, Group 2 innate lymphoid cells in health and disease, Cold Spring Harb Perspect Biol, 7, a016337, 10.1101/cshperspect.a016337
Montanari, 2017, Factors involved in white-to-brown adipose tissue conversion and in thermogenesis: a review, Obes Rev, 18, 495, 10.1111/obr.12520
Brestoff, 2015, Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity, Nature, 519, 242, 10.1038/nature14115
Price, 2010, Systemically dispersed innate IL-13-expressing cells in type 2 immunity, Proc Natl Acad Sci USA, 107, 11489, 10.1073/pnas.1003988107
Molofsky, 2013, Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages, J Exp Med, 210, 535, 10.1084/jem.20121964
Lee, 2015, Activated type 2 innate lymphoid cells regulate beige fat biogenesis, Cell, 160, 74, 10.1016/j.cell.2014.12.011
Wang, 2019, Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity, Nat Commun, 10, 3254, 10.1038/s41467-019-11270-1
O'Rourke, 2014, Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity, Obesity, 22, 2109, 10.1002/oby.20823
Wensveen, 2015, NK cells link obesity-induced adipose stress to inflammation and insulin resistance, Nat Immunol, 16, 376, 10.1038/ni.3120
Revelo, 2015, Perforin is a novel immune regulator of obesity-related insulin resistance, Diabetes, 64, 90, 10.2337/db13-1524
O'Rourke, 2009, Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue, Int J Obes, 33, 978, 10.1038/ijo.2009.133
O'Rourke, 2013, Adipose tissue NK cells manifest an activated phenotype in human obesity, Metabolism, 62, 1557, 10.1016/j.metabol.2013.07.011
Lee, 2016, Adipose natural killer cells regulate adipose tissue macrophages to promote insulin resistance in obesity, Cell Metab, 23, 685, 10.1016/j.cmet.2016.03.002
Michelet, 2018, Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nat Immunol, 19, 1330, 10.1038/s41590-018-0251-7
Theurich, 2017, IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis, Cell Metab, 26, 171, 10.1016/j.cmet.2017.05.018
Starr, 2015, Age-associated increase in cytokine production during systemic inflammation-II: the role of IL-1β in age-dependent IL-6 upregulation in adipose tissue, J Gerontol A Biol Sci Med Sci, 70, 1508, 10.1093/gerona/glu197
Amulic, 2012, Neutrophil function: from mechanisms to disease, Annu Rev Immunol, 30, 459, 10.1146/annurev-immunol-020711-074942
Lacy, 2006, Mechanisms of degranulation in neutrophils, Allergy Asthma Clin Immunol, 2, 98, 10.1186/1710-1492-2-3-98
Papayannopoulos, 2018, Neutrophil extracellular traps in immunity and disease, Nat Rev Immunol, 18, 134, 10.1038/nri.2017.105
Elgazar-Carmon, 2008, Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding, J Lipid Res, 49, 1894, 10.1194/jlr.M800132-JLR200
Revelo, 2016, Nucleic acid-targeting pathways promote inflammation in obesity-related insulin resistance, Cell Rep, 16, 717, 10.1016/j.celrep.2016.06.024
Talukdar, 2012, Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase, Nat Med, 18, 1407, 10.1038/nm.2885
Houghton, 2010, Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth, Nat Med, 16, 219, 10.1038/nm.2084
Nijhuis, 2009, Neutrophil activation in morbid obesity, chronic activation of acute inflammation, Obesity, 17, 2014, 10.1038/oby.2009.113
Brotfain, 2015, Neutrophil functions in morbidly obese subjects, Clin Exp Immunol, 181, 156, 10.1111/cei.12631
Esparza, 1996, Neutrophil function in elderly persons assessed by flow cytometry, Immunol Invest, 25, 185, 10.3109/08820139609059301
Wenisch, 2000, Effect of age on human neutrophil function, J Leukoc Biol, 67, 40, 10.1002/jlb.67.1.40
Butcher, 2001, Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans, J Leukoc Biol, 70, 881, 10.1189/jlb.70.6.881
McLaughlin, 1986, Age-related differences in granulocyte chemotaxis and degranulation, Clin Sci, 70, 59, 10.1042/cs0700059
Fulop, 2004, Signal transduction and functional changes in neutrophils with aging, Aging Cell, 3, 217, 10.1111/j.1474-9728.2004.00110.x
Simell, 2011, Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis, Vaccine, 29, 1929, 10.1016/j.vaccine.2010.12.121
Brubaker, 2013, Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age, J Immunol, 190, 1746, 10.4049/jimmunol.1201213
Banchereau, 2000, Immunobiology of dendritic cells, Annu Rev Immunol, 18, 767, 10.1146/annurev.immunol.18.1.767
Dress, 2019, Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors disctinct from the myeloid lineage, Nat Immunol, 20, 852, 10.1038/s41590-019-0420-3
Macdougall, 2018, Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets, Cell Metab, 27, 588, 10.1016/j.cmet.2018.02.007
Cho, 2016, Adipose tissue dendritic cells are independent contributors to obesity-induced inflammation and insulin resistance, J Immunol, 197, 3650, 10.4049/jimmunol.1600820
Hellmann, 2016, CCR7 maintains nonresolving lymph node and adipose inflammation in obesity, Diabetes, 65, 2268, 10.2337/db15-1689
Ghosh, 2016, Adipose recruitment and activation of plasmacytoid dendritic cells fuel metaflammation, Diabetes, 65, 3440, 10.2337/db16-0331
Hannibal, 2017, Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice, Diabetologia, 60, 2033, 10.1007/s00125-017-4341-0
Ghazarian, 2017, Type I interferon responses drive intrahepatic t cells to promote metabolic syndrome, Sci Immunol, 2, eaai7616, 10.1126/sciimmunol.aai7616
Agrawal, 2007, Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway, J Immunol, 178, 6912, 10.4049/jimmunol.178.11.6912
Klion, 2017, Recent advances in understanding eosinophil biology, F1000Res, 6, 1084, 10.12688/f1000research.11133.1
Wu, 2011, Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis, Science, 332, 243, 10.1126/science.1201475
Fischer, 2017, Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis, Nat Med., 23, 623, 10.1038/nm.4316
Bolus, 2018, Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments, Mol Metab, 8, 86, 10.1016/j.molmet.2017.12.004
Bapat, 2015, Depletion of fat-resident Treg cells prevents age-associated insulin resistance, Nature, 528, 137, 10.1038/nature16151
Mathur, 2008, Age-related changes in eosinophil function in human subjects, Chest, 133, 412, 10.1378/chest.07-2114
Berry, 2017, Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans, Cell Metab, 25, 481, 10.1016/j.cmet.2017.01.011
Kumar, 2019, Temporal immmunometabolic profiling of adipose tissue in HFD-induced obesity: manifestations of mast cells in fibrosis and senescence, Int J Obes, 43, 1281, 10.1038/s41366-018-0228-5
Ishijima, 2013, Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice, FEBS Open Bio, 4, 18, 10.1016/j.fob.2013.11.004
Altintas, 2011, Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice, J Lipid Res, 52, 480, 10.1194/jlr.M011338
Divoux, 2012, Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes, J Clin Endocrinol Metab, 97, E1677, 10.1210/jc.2012-1532
Liu, 2009, Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice, Nat Med, 15, 940, 10.1038/nm.1994
Moreno, 2014, Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects, PLoS ONE, 9, e97014, 10.1371/journal.pone.0097014
Pejler, 2010, Mast cell proteases: multifaceted regulators of inflammatory disease, Blood, 115, 4981, 10.1182/blood-2010-01-257287
Sun, 2007, Mast cells promote atherosclerosis by releasing proinflammatory cytokines, Nat Med., 13, 719, 10.1038/nm1601
Yang, 2008, Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice, Arterioscler Thromb Vasc Biol, 28, 2202, 10.1161/ATVBAHA.108.172320
Gutierrez, 2015, Hematopoietic kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance, Cell Metab, 21, 678, 10.1016/j.cmet.2015.04.013
Chmelar, 2016, No role for mast cells in obesity-related metabolic dysregulation, Front Immunol, 7, 524, 10.3389/fimmu.2016.00524
Nguyen, 2005, Age-induced reprogramming of mast cell degranulation, J Immunol, 175, 5701, 10.4049/jimmunol.175.9.5701
Wu, 2007, Aging up-regulates expression of inflammatory mediators in mouse adipose tissue, J Immunol, 179, 4829, 10.4049/jimmunol.179.7.4829
Gabrilovich, 2009, Myeloid-derived suppressor cells as regulators of the immune system, Nat Rev Immunol, 9, 162, 10.1038/nri2506
Xia, 2011, Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity, J Biol Chem, 286, 23591, 10.1074/jbc.M111.237123
Clements, 2018, Frontline science: high fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells, J Leukoc Biol, 103, 395, 10.1002/JLB.4HI0517-210R
Yan, 2013, Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway, Eur J Immunol, 43, 2943, 10.1002/eji.201343472
Al-Khami, 2017, Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells, Oncoimmunology, 6, e1344804, 10.1080/2162402X.2017.1344804
Enioutina, 2011, A role for immature myeloid cells in immune senescence, J Immunol, 186, 697, 10.4049/jimmunol.1002987
Kennedy, 2015, Inhibition of B lymphopoiesis by adipocytes and IL-1-producing myeloid-derived suppressor cells, J Immunol, 195, 2666, 10.4049/jimmunol.1500957
Winer, 2014, B lymphocytes in obesity-related adipose tissue inflammation and insulin resistance, Cell Mol Life Sci, 71, 1033, 10.1007/s00018-013-1486-y
Nishimura, 2013, Adipose natural regulatory B cells negatively control adipose tissue inflammation, Cell Metab, 18, 759, 10.1016/j.cmet.2013.09.017
Jackson-Jones, 2016, Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation, Nat Commun, 7, 12651, 10.1038/ncomms12651
Winer, 2011, B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies, Nat Med, 17, 610, 10.1038/nm.2353
Tanigaki, 2018, Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance, J Clin Invest, 128, 309, 10.1172/JCI89333
Frasca, 2020, Identification and characterization of adipose tissue-derived human antibodies with “anti-self” specificity, Front Immunol., 11, 392, 10.3389/fimmu.2020.00392
DeFuria, 2013, B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile, Proc Natl Acad Sci USA, 110, 5133, 10.1073/pnas.1215840110
Ying, 2017, Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling, J Clin Invest, 127, 1019, 10.1172/JCI90350
Kim, 2015, BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity, Exp Mol Med, 47, e129, 10.1038/emm.2014.98
Nutt, 2015, The generation of antibody-secreting plasma cells, Nat Rev Immunol, 15, 160, 10.1038/nri3795
Gommerman, 2014, Re-thinking the functions of IgA(+) plasma cells, Gut Microbes, 5, 652, 10.4161/19490976.2014.969977
Luck, 2019, Gut-associated IgA+ immune cells regulate obesity-related insulin resistance, Nat Commun, 10, 3650, 10.1038/s41467-019-11370-y
Carter, 2018, Loss of OcaB prevents age-induced fat accretion and insulin resistance by altering B-lymphocyte transition and promoting energy expenditure, Diabetes, 67, 1285, 10.2337/db17-0558
Bodogai, 2018, Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells, Sci Transl Med, 10, eaat4271, 10.1126/scitranslmed.aat4271
Rubtsova, 2015, Age-associated B cells: a T-bet-dependent effector with roles in protective and pathogenic immunity, J Immunol, 195, 1933, 10.4049/jimmunol.1501209
Hao, 2011, A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice, Blood, 118, 1294, 10.1182/blood-2011-01-330530
Rubtsov, 2011, Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c?, Blood, 118, 1305, 10.1182/blood-2011-01-331462
Ratliff, 2013, In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors, Aging Cell, 12, 303, 10.1111/acel.12055
Frasca, 2017, Obesity induces pro-inflammatory B cells and impairs B cell function in old mice, Mech Ageing Dev, 162, 91, 10.1016/j.mad.2017.01.004
Rubtsova, 2017, B cells expressing the transcription factor T-bet drive lupus-like autoimmunity, J Clin Invest, 127, 1392, 10.1172/JCI91250
Manni, 2018, Regulation of age-associated B cells by IRF5 in systemic autoimmunity, Nat Immunol, 19, 407, 10.1038/s41590-018-0056-8
Khan, 2019, Adipose tissue B cells come of age: the AABs of fat inflammation, Cell Metab, 30, 997, 10.1016/j.cmet.2019.11.007
Winer, 2009, Normalization of obesity-associated insulin resistance through immunotherapy, Nat Med, 15, 921, 10.1038/nm.2001
Feuerer, 2009, Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters, Nat Med, 15, 930, 10.1038/nm.2002
Tiemessen, 2007, CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages, Proc Natl Acad Sci USA, 104, 19446, 10.1073/pnas.0706832104
Cipolletta, 2012, PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells, Nature, 486, 549, 10.1038/nature11132
Kolodin, 2015, Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice, Cell Metab, 21, 543, 10.1016/j.cmet.2015.03.005
Mahlakõiv, 2019, Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33, Sci Immunol, 4, eaax0416, 10.1126/sciimmunol.aax0416
Spallanzani, 2019, Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors, Sci Immunol, 4, eaaw3658, 10.1126/sciimmunol.aaw3658
Vasanthakumar, 2015, The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells, Nat Immunol, 16, 276, 10.1038/ni.3085
Han, 2015, IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance, J Immunol, 194, 4777, 10.4049/jimmunol.1500020
Vasanthakumar, 2020, Sex-specific adipose tissue imprinting of regulatory T cells, Nature, 579, 581, 10.1038/s41586-020-2040-3
McLaughlin, 2014, T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans, Arterioscler Thromb Vasc Biol., 34, 2637, 10.1161/ATVBAHA.114.304636
Wu, 2007, T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity, Circulation, 115, 1029, 10.1161/CIRCULATIONAHA.106.638379
Strissel, 2010, T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice, Obesity, 18, 1918, 10.1038/oby.2010.1
Cho, 2014, An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation, Cell Rep, 9, 605, 10.1016/j.celrep.2014.09.004
McGillicuddy, 2009, Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway, J Biol Chem, 284, 31936, 10.1074/jbc.M109.061655
Pandolfi, 2016, ATP-induced inflammation drives tissue-resident Th17 cells in metabolically unhealthy obesity, J Immunol, 196, 3287, 10.4049/jimmunol.1502506
Jagannathan-Bogdan, 2011, Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes, J Immunol, 186, 1162, 10.4049/jimmunol.1002615
Sumarac-Dumanovic, 2009, Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women, Int J Obes, 33, 151, 10.1038/ijo.2008.216
Ahmed, 2010, IL-17 in obesity and adipogenesis, Cytokine Growth Factor Rev, 21, 449, 10.1016/j.cytogfr.2010.10.005
Cipolletta, 2011, Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism, Semin Immunol, 23, 431, 10.1016/j.smim.2011.06.002
Luck, 2015, Regulation of obesity-related insulin resistance with gut anti-inflammatory agents, Cell Metab, 21, 527, 10.1016/j.cmet.2015.03.001
Nishimura, 2009, CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity, Nat Med, 15, 914, 10.1038/nm.1964
Shuford, 1997, 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses, J Exp Med, 186, 47, 10.1084/jem.186.1.47
Kim, 1998, Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses, Eur J Immunol, 28, 881, 10.1002/(SICI)1521-4141(199803)28:03<881::AID-IMMU881>3.0.CO;2-0
Tu, 2014, Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters, Int J Obes, 38, 1075, 10.1038/ijo.2013.222
Kim, 2011, Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders, Diabetes, 60, 3159, 10.2337/db10-1805
Tsai, 2018, Insulin receptor-mediated stimulation boosts t cell immunity during inflammation and infection, Cell Metab, 28, 922, 10.1016/j.cmet.2018.08.003
Yang, 2010, Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance, J Immunol, 185, 1836, 10.4049/jimmunol.1000021
Tsai, 2015, Are obesity-related insulin resistance and type 2 diabetes autoimmune diseases?, Diabetes, 64, 1886, 10.2337/db14-1488
Ahnstedt, 2018, Sex differences in adipose tissue CD8+ T cells and regulatory T cells in middle-aged mice, Front Immunol., 9, 659, 10.3389/fimmu.2018.00659
Wencker, 2014, Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness, Nat Immunol., 15, 80, 10.1038/ni.2773
Bendelac, 2007, The biology of NKT cells, Annu Rev Immunol, 25, 297, 10.1146/annurev.immunol.25.022106.141711
Dhodapkar, 2017, Type II NKT cells and their emerging role in health and disease, J Immunol, 198, 1015, 10.4049/jimmunol.1601399
Lynch, 2012, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production, Immunity, 37, 574, 10.1016/j.immuni.2012.06.016
Huh, 2017, Deletion of CD1d in adipocytes aggravates adipose tissue inflammation and insulin resistance in obesity, Diabetes, 66, 835, 10.2337/db16-1122
Ji, 2012, Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity, J Biol Chem, 287, 13561, 10.1074/jbc.M112.350066
Lynch, 2015, Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue, Nat Immunol., 16, 85, 10.1038/ni.3047
Satoh, 2018, Role of natural killer T cells in the development of obesity and insulin resistance: insights from recent progress, Front Immunol, 9, 1314, 10.3389/fimmu.2018.01314
Bonneville, 2010, Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity, Nat Rev Immunol, 10, 467, 10.1038/nri2781
Kohlgruber, 2018, γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis, Nat Immunol, 19, 464, 10.1038/s41590-018-0094-2
Le Bourhis, 2011, Mucosal-associated invariant T cells: unconventional development and function, Trends Immunol, 32, 212, 10.1016/j.it.2011.02.005
Chiba, 2018, Mucosal-associated invariant T cells in autoimmune diseases, Front Immunol, 9, 1333, 10.3389/fimmu.2018.01333
Dusseaux, 2011, Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells, Blood, 117, 1250, 10.1182/blood-2010-08-303339
Miyazaki, 2011, Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis, Int Immunol, 23, 529, 10.1093/intimm/dxr047
Le Bourhis, 2010, Antimicrobial activity of mucosal-associated invariant T cells, Nat Immunol, 11, 701, 10.1038/ni.1890
Rahimpour, 2015, Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers, J Exp Med, 212, 1095, 10.1084/jem.20142110
Schipper, 2012, Natural killer T cells in adipose tissue prevent insulin resistance, J Clin Invest., 122, 3343, 10.1172/JCI62739
Lynch, 2009, Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity, Eur J Immunol, 39, 1893, 10.1002/eji.200939349
Subramanian, 2013, Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice, J Lipid Res, 54, 2831, 10.1194/jlr.M041020
Hams, 2013, Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice, J Immunol, 191, 5349, 10.4049/jimmunol.1301176
Chandra, 2015, A new mouse strain for the analysis of invariant NKT cell function, Nat Immunol., 16, 799, 10.1038/ni.3203
Magalhaes, 2015, Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients, J Clin Invest, 125, 1752, 10.1172/JCI78941
Magalhaes, 2015, iNKT and MAIT cell alterations in diabetes, Front Immunol, 6, 341, 10.3389/fimmu.2015.00341
Carolan, 2015, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, J Immunol, 194, 5775, 10.4049/jimmunol.1402945
Faunce, 2005, CD1d-restricted NKT cells contribute to the age-associated decline of T cell immunity, J Immunol, 175, 3102, 10.4049/jimmunol.175.5.3102
Novak, 2014, The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in men and women of reproductive age, Scand J Immunol, 80, 271, 10.1111/sji.12193
Winer, 2016, The intestinal immune system in obesity and insulin resistance, Cell Metab, 23, 413, 10.1016/j.cmet.2016.01.003
Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038/nature05414
Le Chatelier, 2013, consortium, richness of human gut microbiome correlates with metabolic markers, Nature., 500, 541, 10.1038/nature12506
Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science, 341, 1241214, 10.1126/science.1241214
Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337/db06-1491
Ghoshal, 2009, Chylomicrons promote intestinal absorption of lipopolysaccharides, J Lipid Res, 50, 90, 10.1194/jlr.M800156-JLR200
Thevaranjan, 2017, Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction, Cell Host Microbe, 21, 455, 10.1016/j.chom.2017.03.002
Fransen, 2017, Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice, Front Immunol., 8, 1385, 10.3389/fimmu.2017.01385
Li, 2016, Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan, Cell Host Microbe, 19, 240, 10.1016/j.chom.2016.01.008
Lasry, 2015, Senescence-associated inflammatory responses: aging and cancer perspectives, Trends Immunol, 36, 217, 10.1016/j.it.2015.02.009
Rodier, 2009, Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion, Nat Cell Biol, 11, 973, 10.1038/ncb1909
Palmer, 2019, Targeting senescent cells alleviates obesity-induced metabolic dysfunction, Aging Cell, 18, e12950, 10.1111/acel.12950
Shirakawa, 2016, Obesity accelerates T cell senescence in murine visceral adipose tissue, J Clin Invest, 126, 4626, 10.1172/JCI88606
Saucillo, 2014, Leptin metabolically licenses T cells for activation to link nutrition and immunity, J Immunol, 192, 136, 10.4049/jimmunol.1301158
Lord, 1998, Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression, Nature, 394, 897, 10.1038/29795
Santos-Alvarez, 1999, Human leptin stimulates proliferation and activation of human circulating monocytes, Cell Immunol, 194, 6, 10.1006/cimm.1999.1490