The Identification of Contact Allergens by Animal Assay. the Guinea Pig Maximization Test**From the Department of Dermatology, University of Gothenburg, Sahlgrenska Sjukhuset, Gothenburg, Sweden and the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.

Draize, 1944, Methods for the study of irritation and toxicity of substances applied topically to 276 THE JOURNAL OF INVESTIGATIVE DERMATOLOGY the skin and mucous membranes, J. Pharm. Exp. Ther., 82, 377

Draize, 1959, Dermal toxicity, 46

Landsteiner, 1935, Studies on the sensitization of animals with simple chemical compounds, J. Exp. Med., 61, 643, 10.1084/jem.61.5.643

Chase, 1954, Experimental sensitization with particular reference to picryl chloride, Int. Arch. Allerg., 5, 163, 10.1159/000228095

Voss, 1958, Skin sensitization by mercaptans of low molecular weight, J. Invest. Derm., 31, 273, 10.1038/jid.1958.120

Buehler, 1965, Delayed contact hypersensitivity in the guinea pig, Arch. Derm., 91, 171, 10.1001/archderm.1965.01600080079017

Maguire, 1967, Exaggerated delayed-type hypersensitivity to simple chemical allergens in the guinea pig, J. Invest. Derm., 49, 460, 10.1038/jid.1967.166

Hood, D. B.: Personal communication

Kligman, 1966, The SLS provocative patch test in allergic contact sensitization, J. Invest. Derm., 46, 573, 10.1038/jid.1966.87

Kligman, 1966, The identification of contact allergens by human assay. I. A critique of standard methods, J. Invest. Derm., 41, 369, 10.1038/jid.1966.158

Kligman, 1966, The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis, J. Invest. Derm., 47, 375, 10.1038/jid.1966.159

Kligman, 1966, The identification of contact allergens by human assay. III. The maximization test: A procedure for screening and rating contact sensitizers, J. Invest. Derm., 47, 393, 10.1038/jid.1966.160

Chase, 1941, Inheritance in guinea pigs of the susceptibility to skin sensitization with simple chemical compounds, J. Exp. Med., 73, 711, 10.1084/jem.73.6.711

Chase, 1953, The inheritance of susceptibility to drug allergy in guinea pigs, Trans. New York Acad. Sci., 15, 79, 10.1111/j.2164-0947.1953.tb01310.x

Polak, 1968, The genetic control of contact sensitization to inorganic metal compounds in guineapigs, Immunology, 14, 707

Freund, 1956, The mode of action of immunologic adjuvants, Adv. Tuberc. Res., 7, 130

Fisher, 1958, Experimental toxic and allergic contact dermatitis. II. A histopathologic study, J. Allerg., 29, 411, 10.1016/0021-8707(58)90083-2

Miescher, 1962, Ekzem. Histopathologie, morphologie, nosologie, 1