The Hallmarks of Cancer

Aplin, 1998, Signal transduction and signal modulation by cell adhesion receptors, Pharmacol. Rev., 50, 197

Ashkenazi, 1999, Apoptosis control by death and decoy receptors, Curr. Opin. Cell Biol., 11, 255, 10.1016/S0955-0674(99)80034-9

Bergers, 2000, Extrinsic regulators of epithelial tumor progression, Curr. Opin. Genet. Dev., in press

Bergers, 1998, Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis, Int. J. Dev. Biol., 42, 995

Bergers, 1999, Effects of angiogenesis inhibitors on multistage carcinogenesis in mice, Science, 284, 808, 10.1126/science.284.5415.808

1996

Bodnar, 1998, Extension of life-span by introduction of telomerase into normal human cells, Science, 279, 349, 10.1126/science.279.5349.349

Bouck, 1996, How tumors become angiogenic, Adv. Cancer Res., 69, 135, 10.1016/S0065-230X(08)60862-3

Bryan, 1999, Telomerase and the maintenance of chromosome ends, Curr. Opin. Cell Biol., 11, 318, 10.1016/S0955-0674(99)80043-X

Bryan, 1995, Telomere elongation in immortal human cells without detectable telomerase activity, EMBO J., 14, 4240, 10.1002/j.1460-2075.1995.tb00098.x

Bull, 1994, Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells, FEBS Lett., 351, 41, 10.1016/0014-5793(94)00814-0

Butt, 1999, The IGF axis and programmed cell death, Immunol. Cell Biol., 77, 256, 10.1046/j.1440-1711.1999.00822.x

Cantley, 1999, New insights into tumor suppression, Proc. Natl. Acad. Sci. USA, 96, 4240, 10.1073/pnas.96.8.4240

Chambers, 1997, Changing views of the role of matrix metalloproteinases in metastasis, J. Natl. Cancer Inst., 89, 1260, 10.1093/jnci/89.17.1260

Chin, 1998, The INK4a/ARF tumor suppressor, Trends Biochem. Sci., 23, 291, 10.1016/S0968-0004(98)01236-5

Christofori, 1999, The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene, Trends Biochem. Sci., 24, 73, 10.1016/S0968-0004(98)01343-7

Christofori, 1994, A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis, Nature, 369, 414, 10.1038/369414a0

Cordon-Cardo, 1999, At the crossroads of inflammation and tumorigenesis, J. Exp. Med., 190, 1367, 10.1084/jem.190.10.1367

Counter, 1992, Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity, EMBO J., 11, 1921, 10.1002/j.1460-2075.1992.tb05245.x

Counter, 1998, Dissociation between telomerase activity, telomere maintenance and cellular immortalization, Proc. Natl. Acad. Sci. USA, 95, 14723, 10.1073/pnas.95.25.14723

Coussens, 1996, Matrix metalloproteinases and the development of cancer, Chem. Biol., 3, 895, 10.1016/S1074-5521(96)90178-7

Coussens, 1999, Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis, Genes Dev., 13, 1382, 10.1101/gad.13.11.1382

Dameron, 1994, Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1, Science, 265, 1582, 10.1126/science.7521539

Datto, 1997, The viral oncoprotein E1A blocks transforming growth factor β-mediated induction of p21/WAF1/Cip1 and p15/INK4B Mol, Cell. Biol., 17, 2030

DiFiore, 1987, erb B-2 is a potent oncogene when overexpressed in NIH/3T3 cells, Science, 237, 178, 10.1126/science.2885917

Downward, 1998, Mechanisms and consequences of activation of protein kinase B/Akt, Curr. Opin. Cell Biol., 10, 262, 10.1016/S0955-0674(98)80149-X

Dyson, 1989, The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product, Science, 243, 934, 10.1126/science.2537532

Evan, 1998, A matter of life and cell death, Science, 281, 1317, 10.1126/science.281.5381.1317

Fedi, 1997, Growth factors

Fogar, 1997, Neural cell adhesion molecule (N-CAM) in gastrointestinal neoplasias, Anticancer Res., 17, 1227

Foley, 1999, Two MAD tails, Biochim. Biophys. Acta, 1423, M37

Folkman, 1997, Tumor angiogenesis

Foulds, 1954

Fynan, 1993, Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis, Crit. Rev. Oncog., 4, 493

Gately, 1997, The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin, Proc. Natl. Acad. Sci. USA, 94, 10868, 10.1073/pnas.94.20.10868

Giancotti, 1999, Integrin signaling, Science, 285, 1028, 10.1126/science.285.5430.1028

Green, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309

Greenberg, 1999, Short dysfunctional telomeres impair tumorigenesis in the INK4aΔ2/3 cancer-prone mouse, Cell, 97, 515, 10.1016/S0092-8674(00)80761-8

Hahn, 1999, Creation of human tumor cells with defined genetic elements, Nature, 400, 464, 10.1038/22780

Halvorsen, 1999, Telomerase activity is sufficient to allow transformed cells to escape from crisis, Mol. Cell. Biol., 19, 1864, 10.1128/MCB.19.3.1864

Hanahan, 1996, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Cell, 86, 353, 10.1016/S0092-8674(00)80108-7

Hannon, 1994, P15INK4B is a potential effector of TGF-beta-induced cell cycle arrest, Nature, 371, 257, 10.1038/371257a0

Harris, 1996, p53 tumor suppressor gene, Carcinogenesis, 17, 1187, 10.1093/carcin/17.6.1187

Hayflick, 1997, Mortality and immortality at the cellular level. A review, Biochemistry, 62, 1180

Holmgren, 1999, Horizontal transfer of DNA by the uptake of apoptotic bodies, Blood, 93, 3956, 10.1182/blood.V93.11.3956

Hudson, 1999, A proinflammatory cytokine inhibits p53 tumor suppressor activity, J. Exp. Med., 190, 1375, 10.1084/jem.190.10.1375

Hueber, 1997, Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis, Science, 278, 1305, 10.1126/science.278.5341.1305

Hunter, 1997, Oncoprotein networks, Cell, 88, 333, 10.1016/S0092-8674(00)81872-3

Hynes, 1996, Genetic manipulation of vascular adhesion molecules in mice, J. Clin. Invest., 98, 2193, 10.1172/JCI119027

Ishizaki, 1995, Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells, Mol. Biol. Cell, 6, 1443, 10.1091/mbc.6.11.1443

Johnsen, 1998, Cancer invasion and tissue remodeling, Curr. Opin. Cell Biol., 10, 667, 10.1016/S0955-0674(98)80044-6

Johnson, 1991, Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease, Cancer Metastasis Rev., 10, 11, 10.1007/BF00046840

Kahn, 1986, v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation, Cell, 45, 349, 10.1016/0092-8674(86)90320-X

Kaiser, 1996, The neural cell adhesion molecule NCAM in multiple myeloma, Leuk. Lymphoma, 20, 389, 10.3109/10428199609052420

Kerr, 1972, Apoptosis, Br. J. Cancer, 26, 239, 10.1038/bjc.1972.33

Kim, 1993, Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo, Nature, 362, 841, 10.1038/362841a0

Kinzler, 1996, Lessons from hereditary colorectal cancer, Cell, 87, 159, 10.1016/S0092-8674(00)81333-1

Kinzler, 1998, Landscaping the cancer terrain, Science, 280, 1036, 10.1126/science.280.5366.1036

Korsmeyer, 1992, Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes, Annu. Rev. Immunol., 10, 785, 10.1146/annurev.iy.10.040192.004033

Lengauer, 1998, Genetic instabilities in human cancers, Nature, 396, 643, 10.1038/25292

Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1

Loeb, 1991, Mutator phenotype may be required for multistep carcinogenesis, Cancer Res., 51, 3073

Lotem, 1996, Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes, Leukemia, 10, 925

Lukashev, 1998, ECM signaling, Trends Cell Biol., 8, 437, 10.1016/S0962-8924(98)01362-2

Markowitz, 1995, Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability, Science, 268, 1336, 10.1126/science.7761852

Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, 399, 271, 10.1038/20459

McDonnell, 1991, Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18), Nature, 349, 254, 10.1038/349254a0

Medema, 1993, The role of p21-ras in receptor tyrosine kinase signaling, Crit. Rev. Oncog., 4, 615

Millauer, 1994, Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant, Nature, 367, 576, 10.1038/367576a0

Moses, 1990, TGF-β stimulation and inhibition of cell proliferation, Cell, 63, 245, 10.1016/0092-8674(90)90155-8

Nowell, 1976, The clonal evolution of tumor cell populations, Science, 194, 23, 10.1126/science.959840

Olumi, 1999, Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Cancer Res., 59, 5002

Perl, 1999, Reduced expresion of neural cell adhesion molecule induces metastatic dissemination of pancreatic β tumor cells, Nat. Med., 5, 286, 10.1038/6502

Pitti, 1998, Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer, Nature, 396, 699, 10.1038/25387

Rak, 1995, Oncogenes as inducers of tumor angiogenesis, Cancer Metastasis Rev., 14, 263, 10.1007/BF00690598

Renan, 1993, How many mutations are required for tumorigenesis? Implications from human cancer data, Mol. Carcinogenesis, 7, 139, 10.1002/mc.2940070303

Rommel, 1998, Ras—a versatile cellular switch, Curr. Opin. Genet. Dev., 8, 412, 10.1016/S0959-437X(98)80111-1

Schutte, 1996, DPC4 gene in various tumor types, Cancer Res., 56, 2527

Serrano, 1997, Oncogeneic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4A, Cell, 88, 593, 10.1016/S0092-8674(00)81902-9

Shibata, 1996, p53-independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice, Cancer Res., 56, 2998

Shay, 1997, A survey of telomerase activity in human cancer, Eur. J. Cancer, 33, 787, 10.1016/S0959-8049(97)00062-2

Singh, 1995, Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas, Proc. Natl. Acad. Sci. USA, 92, 4562, 10.1073/pnas.92.10.4562

Skobe, 1998, Tumorigenic conversion of immortal human keratinocytes through stromal cell activation, Proc. Natl. Acad. Sci. USA, 95, 1050, 10.1073/pnas.95.3.1050

Slamon, 1987, Human breast cancer, Science, 235, 177, 10.1126/science.3798106

Sporn, 1996, The war on cancer, Lancet, 347, 1377, 10.1016/S0140-6736(96)91015-6

Stetler-Stevenson, 1999, Matrix metalloproteinases in angiogenesis, J. Clin. Invest., 103, 1237, 10.1172/JCI6870

Strasser, 1990, Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2, Nature, 348, 331, 10.1038/348331a0

Symonds, 1994, p53-dependent apoptosis suppresses tumor growth and progression in vivo, Cell, 78, 703, 10.1016/0092-8674(94)90534-7

Thornberry, 1998, Caspases, Science, 281, 1312, 10.1126/science.281.5381.1312

Varner, 1996, Integrins and cancer, Curr. Opin. Cell Biol., 8, 724, 10.1016/S0955-0674(96)80115-3

Vaux, 1988, Bcl-2 promotes the survival of hematopoietic cells and cooperates with c-myc to immortalize pre-B cells, Nature, 335, 440, 10.1038/335440a0

Vaziri, 1998, Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span, Curr. Biol., 8, 279, 10.1016/S0960-9822(98)70109-5

Veikkola, 1999, VEGFs, receptors and angiogenesis, Semin. Cancer Biol., 9, 211, 10.1006/scbi.1998.0091

Volpert, 1997, Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity, Oncogene, 14, 1495, 10.1038/sj.onc.1200977

Weinberg, 1995, The retinoblastoma protein and cell cycle control, Cell, 81, 323, 10.1016/0092-8674(95)90385-2

Werb, 1997, ECM and cell surface proteolysis, Cell, 91, 439, 10.1016/S0092-8674(00)80429-8

Whitelock, 1996, The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases, J. Biol. Chem., 271, 10079, 10.1074/jbc.271.17.10079

Wright, 1989, Reversible cellular senescence, Mol. Cell. Biol., 9, 3088, 10.1128/MCB.9.7.3088

Wyllie, 1980, Cell death, Int. Rev. Cytol., 68, 251, 10.1016/S0074-7696(08)62312-8

Yarden, 1988, EGF and erbB2 receptor overexpression in human tumors. Growth factor recepor tyrosine kinases, Annu. Rev. Biochem., 57, 443, 10.1146/annurev.bi.57.070188.002303

Zhu, 1999, Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening, Proc. Natl. Acad. Sci. USA, 96, 3723, 10.1073/pnas.96.7.3723

Zuo, 1996, Germline mutations in the p16INK4A binding domain of CDK4 in familial melanoma, Nat. Genet., 12, 97, 10.1038/ng0196-97