The Gut Microbiota and Liver Disease
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Qin, 2010, A human gut microbial gene catalogue established by metagenomic sequencing, Nature, 464, 59, 10.1038/nature08821
Sonnenburg, 2005, Glycan foraging in vivo by an intestine-adapted bacterial symbiont, Science, 307, 1955, 10.1126/science.1109051
Yatsunenko, 2012, Human gut microbiome viewed across age and geography, Nature, 486, 222, 10.1038/nature11053
Olszak, 2012, Microbial exposure during early life has persistent effects on natural killer T cell function, Science, 336, 489, 10.1126/science.1219328
Uematsu, 2008, Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5, Nat Immunol, 9, 769, 10.1038/ni.1622
Ley, 2006, Microbial ecology: human gut microbes associated with obesity, Nature, 444, 1022, 10.1038/4441022a
Kau, 2011, Human nutrition, the gut microbiome and the immune system, Nature, 474, 327, 10.1038/nature10213
Frank, 2007, Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases, Proc Natl Acad Sci USA, 104, 13780, 10.1073/pnas.0706625104
Hsiao, 2013, Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders, Cell, 155, 1451, 10.1016/j.cell.2013.11.024
Yoshimoto, 2013, Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome, Nature, 499, 97, 10.1038/nature12347
Hartmann, 2013, Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice, Hepatology, 58, 108, 10.1002/hep.26321
Grivennikov, 2012, Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth, Nature, 491, 254, 10.1038/nature11465
Yan, 2011, Enteric dysbiosis associated with a mouse model of alcoholic liver disease, Hepatology, 53, 96, 10.1002/hep.24018
Zhu, 2013, Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH, Hepatology, 57, 601, 10.1002/hep.26093
Chen, 2015, Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice, Hepatology, 61, 883, 10.1002/hep.27489
Turnbaugh, 2009, A core gut microbiome in obese and lean twins, Nature, 457, 480, 10.1038/nature07540
Jumpertz, 2011, Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans, Am J Clin Nutr, 94, 58, 10.3945/ajcn.110.010132
Backhed, 2004, The gut microbiota as an environmental factor that regulates fat storage, Proc Natl Acad Sci USA, 101, 15718, 10.1073/pnas.0407076101
Leclercq, 2014, Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity, Proc Natl Acad Sci USA, 111, E4485, 10.1073/pnas.1415174111
Bode, 1984, Jejunal microflora in patients with chronic alcohol abuse, Hepatogastroenterology, 31, 30
Mutlu, 2012, Colonic microbiome is altered in alcoholism, Am J Physiol Gastrointest Liver Physiol, 302, G966, 10.1152/ajpgi.00380.2011
Mutlu, 2009, Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats, Alcohol Clin Exp Res, 33, 1836, 10.1111/j.1530-0277.2009.01022.x
Bull-Otterson, 2013, Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment, PloS One, 8, e53028, 10.1371/journal.pone.0053028
Chen, 2015, Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice, Gastroenterology, 148, 203, 10.1053/j.gastro.2014.09.014
Wang, 2011, Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury, Am J Pathol, 179, 2866, 10.1016/j.ajpath.2011.08.039
Brandl, 2008, Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits, Nature, 455, 804, 10.1038/nature07250
Cho, 2012, Antibiotics in early life alter the murine colonic microbiome and adiposity, Nature, 488, 621, 10.1038/nature11400
Hildebrand, 2008, Early-life exposures associated with antibiotic use and risk of subsequent Crohn’s disease, Scand J Gastroenterol, 43, 961, 10.1080/00365520801971736
Card, 2004, Antibiotic use and the development of Crohn’s disease, Gut, 53, 246, 10.1136/gut.2003.025239
Gilat, 1987, Childhood factors in ulcerative colitis and Crohn’s disease: an international cooperative study, Scand J Gastroenterol, 22, 1009, 10.3109/00365528708991950
Dominguez-Bello, 2010, Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns, Proc Natl Acad Sci USA, 107, 11971, 10.1073/pnas.1002601107
Charlson, 2010, Disordered microbial communities in the upper respiratory tract of cigarette smokers, PloS One, 5, e15216, 10.1371/journal.pone.0015216
Benjamin, 2012, Smokers with active Crohn’s disease have a clinically relevant dysbiosis of the gastrointestinal microbiota, Inflamm Bowel Dis, 18, 1092, 10.1002/ibd.21864
Biedermann, 2013, Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans, PloS One, 8, e59260, 10.1371/journal.pone.0059260
Walk, 2010, Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus, Inflamm Bowel Dis, 16, 1841, 10.1002/ibd.21299
Lee, 2011, Comparison of the gut microbiotas of healthy adult twins living in South Korea and the United States, Appl Environ Microbiol, 77, 7433, 10.1128/AEM.05490-11
Dicksved, 2008, Molecular analysis of the gut microbiota of identical twins with Crohn’s disease, ISME J, 2, 716, 10.1038/ismej.2008.37
Benson, 2010, Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors, Proc Natl Acad Sci USA, 107, 18933, 10.1073/pnas.1007028107
Knights, 2014, Complex host genetics influence the microbiome in inflammatory bowel disease, Genome Med, 6, 107, 10.1186/s13073-014-0107-1
Bruns, 2012, NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis, Liver Int, 32, 223, 10.1111/j.1478-3231.2011.02561.x
Appenrodt, 2010, Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis, Hepatology, 51, 1327, 10.1002/hep.23440
Saner, 2014, A non-interventional study of the genetic polymorphisms of NOD2 associated with increased mortality in non-alcoholic liver transplant patients, BMC Gastroenterol, 14, 4, 10.1186/1471-230X-14-4
Elinav, 2011, NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis, Cell, 145, 745, 10.1016/j.cell.2011.04.022
Henao-Mejia, 2012, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, 482, 179, 10.1038/nature10809
Hedin, 2014, Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn’s disease and their unaffected siblings, Gut, 63, 1578, 10.1136/gutjnl-2013-306226
Hooper, 2012, Interactions between the microbiota and the immune system, Science, 336, 1268, 10.1126/science.1223490
Swidsinski, 2007, Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota, Inflamm Bowel Dis, 13, 963, 10.1002/ibd.20163
Sommer, 2013, The gut microbiota—masters of host development and physiology, Nat Rev Microbiol, 11, 227, 10.1038/nrmicro2974
Yang, 2001, Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37), J Leukoc Biol, 69, 691, 10.1189/jlb.69.5.691
Kubinak, 2015, MyD88 Signaling in T cells directs IgA-mediated control of the microbiota to promote health, Cell Host Microbe, 17, 153, 10.1016/j.chom.2014.12.009
Macpherson, 2000, A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria, Science, 288, 2222, 10.1126/science.288.5474.2222
Kawamoto, 2012, The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut, Science, 336, 485, 10.1126/science.1217718
Petnicki-Ocwieja, 2009, Nod2 is required for the regulation of commensal microbiota in the intestine, Proc Natl Acad Sci USA, 106, 15813, 10.1073/pnas.0907722106
Salzman, 2010, Enteric defensins are essential regulators of intestinal microbial ecology, Nat Immunol, 11, 76, 10.1038/ni.1825
Vaishnava, 2011, The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine, Science, 334, 255, 10.1126/science.1209791
Teltschik, 2012, Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense, Hepatology, 55, 1154, 10.1002/hep.24789
Johansson, 2011, The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions, Proc Natl Acad Sci USA, 108, 4659, 10.1073/pnas.1006451107
Juge, 2012, Microbial adhesins to gastrointestinal mucus, Trends Microbiol, 20, 30, 10.1016/j.tim.2011.10.001
Derrien, 2010, Mucin-bacterial interactions in the human oral cavity and digestive tract, Gut Microbes, 1, 254, 10.4161/gmic.1.4.12778
Zarepour, 2013, The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis, Infect Immun, 81, 3672, 10.1128/IAI.00854-13
Sovran, 2015, IL-22-STAT3 pathway plays a key role in the maintenance of ileal homeostasis in mice lacking secreted mucus barrier, Inflamm Bowel Dis, 21, 531, 10.1097/MIB.0000000000000319
Qin, 2014, Alterations of the human gut microbiome in liver cirrhosis, Nature, 513, 59, 10.1038/nature13568
Scobie, 1964, Reduced gastric acid output in cirrhosis: quantitation and relationships, Gut, 5, 422, 10.1136/gut.5.5.422
Lu, 2011, Intestinal microbiota was assessed in cirrhotic patients with hepatitis B virus infection. Intestinal microbiota of HBV cirrhotic patients, Microb Ecol, 61, 693, 10.1007/s00248-010-9801-8
Schnabl, 2014, Interactions between the intestinal microbiome and liver diseases, Gastroenterology, 146, 1513, 10.1053/j.gastro.2014.01.020
Hartmann, 2015, Alcoholic liver disease: the gut microbiome and liver crosstalk, Alcohol Clin Exp Res, 39, 763, 10.1111/acer.12704
De Minicis, 2014, Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice, Hepatology, 59, 1738, 10.1002/hep.26695
Cani, 2007, Metabolic endotoxemia initiates obesity and insulin resistance, Diabetes, 56, 1761, 10.2337/db06-1491
Teixeira, 2012, Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors, Clin Nutr, 31, 735, 10.1016/j.clnu.2012.02.009
Miele, 2009, Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease, Hepatology, 49, 1877, 10.1002/hep.22848
Keshavarzian, 1994, The differing effects of acute and chronic alcohol on gastric and intestinal permeability, Am J Gastroenterol, 89, 2205
Pendyala, 2011, Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis, Am J Clin Nutr, 93, 234, 10.3945/ajcn.110.002683
Ding, 2010, High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse, PLoS One, 5, e12191, 10.1371/journal.pone.0012191
Amar, 2008, Energy intake is associated with endotoxemia in apparently healthy men, Am J Clin Nutr, 87, 1219, 10.1093/ajcn/87.5.1219
Erridge, 2007, A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation, Am J Clin Nutr, 86, 1286, 10.1093/ajcn/86.5.1286
Alisi, 2010, Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children, J Pediatr Gastroenterol Nutr, 50, 645, 10.1097/MPG.0b013e3181c7bdf1
Farhadi, 2008, Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis, Liver Int, 28, 1026, 10.1111/j.1478-3231.2008.01723.x
Garcia-Tsao, 1995, Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites, Gastroenterology, 108, 1835, 10.1016/0016-5085(95)90147-7
Saitoh, 1999, Increased prevalence of intestinal inflammation in patients with liver cirrhosis, World J Gastroenterol, 5, 391, 10.3748/wjg.v5.i5.391
Du Plessis, 2013, Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function, J Hepatol, 58, 1125, 10.1016/j.jhep.2013.01.038
Wiest, 2014, Reply to: “Bacterial translocation in liver cirrhosis: site and role in fibrogenesis”, J Hepatol, 61, 710, 10.1016/j.jhep.2014.06.004
Wiest, 2014, Pathological bacterial translocation in liver cirrhosis, J Hepatol, 60, 197, 10.1016/j.jhep.2013.07.044
Uesugi, 2001, Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice, Hepatology, 34, 101, 10.1053/jhep.2001.25350
Hritz, 2008, The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88, Hepatology, 48, 1224, 10.1002/hep.22470
Seki, 2007, TLR4 enhances TGF-beta signaling and hepatic fibrosis, Nat Med, 13, 1324, 10.1038/nm1663
Hartmann, 2012, Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice, Gastroenterology, 143, 1330, 10.1053/j.gastro.2012.07.099
Saberi, 2009, Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice, Cell Metab, 10, 419, 10.1016/j.cmet.2009.09.006
Miura, 2010, Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1 beta in mice, Gastroenterology, 139, 323, 10.1053/j.gastro.2010.03.052
Rivera, 2007, Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis, J Hepatol, 47, 571, 10.1016/j.jhep.2007.04.019
Cani, 2008, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, 57, 1470, 10.2337/db07-1403
Adachi, 1995, Antibiotics prevent liver injury in rats following long-term exposure to ethanol, Gastroenterology, 108, 218, 10.1016/0016-5085(95)90027-6
Douhara, 2015, Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model, Mol Med Rep, 11, 1693, 10.3892/mmr.2014.2995
Bode, 1997, Effect of treatment with paromomycin on endotoxemia in patients with alcoholic liver disease—a double-blind, placebo-controlled trial, Alcohol Clin Exp Res, 21, 1367
Bass, 2010, Rifaximin treatment in hepatic encephalopathy, N Engl J Med, 362, 1071, 10.1056/NEJMoa0907893
Mazagova, 2015, Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice, FASEB J, 29, 1043, 10.1096/fj.14-259515
Wikoff, 2009, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites, Proc Natl Acad Sci USA, 106, 3698, 10.1073/pnas.0812874106
Venkatesh, 2014, Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4, Immunity, 41, 296, 10.1016/j.immuni.2014.06.014
Abu-Shanab, 2010, The role of the gut microbiota in nonalcoholic fatty liver disease, Nat Rev Gastroenterol Hepatol, 7, 691, 10.1038/nrgastro.2010.172
Hildebrandt, 2009, High-fat diet determines the composition of the murine gut microbiome independently of obesity, Gastroenterology, 137, 1716, 10.1053/j.gastro.2009.08.042
Conterno, 2011, Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?, Genes Nutr, 6, 241, 10.1007/s12263-011-0230-1
Backhed, 2007, Mechanisms underlying the resistance to diet-induced obesity in germ-free mice, Proc Natl Acad Sci USA, 104, 979, 10.1073/pnas.0605374104
Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science, 341, 1241214, 10.1126/science.1241214
Turnbaugh, 2006, An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, 444, 1027, 10.1038/nature05414
Nair, 2001, Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis, Am J Gastroenterol, 96, 1200, 10.1111/j.1572-0241.2001.03702.x
Cope, 2000, Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis, Gastroenterology, 119, 1340, 10.1053/gast.2000.19267
Hartmann, 2012, The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease, Front Physiol, 3, 402, 10.3389/fphys.2012.00402
Jokelainen, 1994, In vitro acetaldehyde formation by human colonic bacteria, Gut, 35, 1271, 10.1136/gut.35.9.1271
Abdelmegeed, 2013, CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis, Free Radic Biol Med, 65, 1238, 10.1016/j.freeradbiomed.2013.09.009
Forsyth, 2013, Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability, Am J Physiol Gastrointest Liver Physiol, 305, G185, 10.1152/ajpgi.00354.2012
Rao, 2008, Acetaldehyde-induced barrier disruption and paracellular permeability in Caco-2 cell monolayer, Methods Mol Biol, 447, 171, 10.1007/978-1-59745-242-7_13
Dumas, 2006, Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice, Proc Natl Acad Sci USA, 103, 12511, 10.1073/pnas.0601056103
Jiang, 2005, Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants, J Biol Chem, 280, 18336, 10.1074/jbc.M500007200
Blumberg, 1941, The prevention by choline of liver cirrhosis in rats on high fat, low protein diets, Science, 93, 598, 10.1126/science.93.2425.598
Spencer, 2011, Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency, Gastroenterology, 140, 976, 10.1053/j.gastro.2010.11.049