The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
Tóm tắt
Từ khóa
Tài liệu tham khảo
Bian, 2009, Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice, Arthritis Res. Ther., 11, R132, 10.1186/ar2799
Brand, 2009, Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease, Gut, 58, 1152, 10.1136/gut.2008.163667
Byersdorfer, 2013, Effector T cells require fatty acid metabolism during murine graft-versus-host disease, Blood, 122, 3230, 10.1182/blood-2013-04-495515
Carrette, 2012, IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis, Semin. Immunol., 24, 209, 10.1016/j.smim.2012.04.010
Cham, 2005, Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells, J. Immunol., 174, 4670, 10.4049/jimmunol.174.8.4670
Chang, 2013, Posttranscriptional control of T cell effector function by aerobic glycolysis, Cell, 153, 1239, 10.1016/j.cell.2013.05.016
Chen, 2003, Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice, Exp. Hematol., 31, 953, 10.1016/S0301-472X(03)00196-6
Darzynkiewicz, 2001, Analysis of DNA content and BrdU incorporation, Curr. Protoc. Cytom., Chapter 7, 7
Delgoffe, 2009, The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment, Immunity, 30, 832, 10.1016/j.immuni.2009.04.014
Delgoffe, 2011, The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2, Nat. Immunol., 12, 295, 10.1038/ni.2005
Düvel, 2010, Activation of a metabolic gene regulatory network downstream of mTOR complex 1, Mol. Cell, 39, 171, 10.1016/j.molcel.2010.06.022
Eleftheriadis, 2013, Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory T-cell differentiation in alloreactive human lymphocytes, J. Basic Clin. Physiol. Pharmacol., 24, 271, 10.1515/jbcpp-2013-0001
Frauwirth, 2002, The CD28 signaling pathway regulates glucose metabolism, Immunity, 16, 769, 10.1016/S1074-7613(02)00323-0
Gatza, 2011, Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease, Sci. Transl. Med., 3, ra8, 10.1126/scitranslmed.3001975
Gubser, 2013, Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch, Nat. Immunol., 14, 1064, 10.1038/ni.2687
Hale, 2005, Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria, Inflamm. Bowel Dis., 11, 1060, 10.1097/01.MIB.0000187582.90423.bc
Jacobs, 2008, Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways, J. Immunol., 180, 4476, 10.4049/jimmunol.180.7.4476
Jacobs, 2010, IL-7 is essential for homeostatic control of T cell metabolism in vivo, J. Immunol., 184, 3461, 10.4049/jimmunol.0902593
Kidani, 2013, Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity, Nat. Immunol., 14, 489, 10.1038/ni.2570
MacIver, 2011, The liver kinase B1 is a central regulator of T cell development, activation, and metabolism, J. Immunol., 187, 4187, 10.4049/jimmunol.1100367
MacIver, 2013, Metabolic regulation of T lymphocytes, Annu. Rev. Immunol., 31, 259, 10.1146/annurev-immunol-032712-095956
Masui, 2013, mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc, Cell Metab., 18, 726, 10.1016/j.cmet.2013.09.013
McCracken, 2013, Nutrient transporters: the Achilles’ heel of anabolism, Trends Endocrinol. Metab., 24, 200, 10.1016/j.tem.2013.01.002
Michalek, 2011, Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets, J. Immunol., 186, 3299, 10.4049/jimmunol.1003613
Michalek, 2011, Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation, Proc. Natl. Acad. Sci. USA, 108, 18348, 10.1073/pnas.1108856108
Mottet, 2003, Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells, J. Immunol., 170, 3939, 10.4049/jimmunol.170.8.3939
Ostroukhova, 2012, The role of low-level lactate production in airway inflammation in asthma, Am. J. Physiol. Lung Cell. Mol. Physiol., 302, L300, 10.1152/ajplung.00221.2011
Pearce, 2009, Enhancing CD8 T-cell memory by modulating fatty acid metabolism, Nature, 460, 103, 10.1038/nature08097
Rathmell, 2001, IL-7 enhances the survival and maintains the size of naive T cells, J. Immunol., 167, 6869, 10.4049/jimmunol.167.12.6869
Rudolph, 2011, Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell, Am. J. Physiol. Endocrinol. Metab., 300, E1059, 10.1152/ajpendo.00083.2011
Saha, 2013, Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality, Blood, 122, 3062, 10.1182/blood-2013-05-500801
Sena, 2013, Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling, Immunity, 38, 225, 10.1016/j.immuni.2012.10.020
Shi, 2011, HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells, J. Exp. Med., 208, 1367, 10.1084/jem.20110278
Shortman, 1990, The generation and fate of thymocytes, Semin. Immunol., 2, 3
Sinclair, 2013, Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation, Nat. Immunol., 14, 500, 10.1038/ni.2556
Thorens, 2010, Glucose transporters in the 21st Century, Am. J. Physiol. Endocrinol. Metab., 298, E141, 10.1152/ajpendo.00712.2009
van der Windt, 2012, Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development, Immunity, 36, 68, 10.1016/j.immuni.2011.12.007
Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809
Waickman, 2012, mTOR, metabolism, and the regulation of T-cell differentiation and function, Immunol. Rev., 249, 43, 10.1111/j.1600-065X.2012.01152.x
Wang, 2011, The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation, Immunity, 35, 871, 10.1016/j.immuni.2011.09.021
Wieman, 2007, Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking, Mol. Biol. Cell, 18, 1437, 10.1091/mbc.E06-07-0593
Young, 2011, Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo, PLoS ONE, 6, e23205, 10.1371/journal.pone.0023205
Zeng, 2013, mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function, Nature, 499, 485, 10.1038/nature12297