The Global Epidemiology of Hepatocellular Carcinoma: Present and Future

Ferlay

Zimmerman, 2010, Paleopathology Newsletter, 150, 16

Frerichs, 1879

Osler, 1912

Ferlay

Sun, 2002, Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan, Br J Cancer, 87, 966, 10.1038/sj.bjc.6600584

Altekruse, 2009, Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005, J Clin Oncol, 27, 1485, 10.1200/JCO.2008.20.7753

Tanaka, 2008, Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003, Ann Intern Med, 148, 820, 10.7326/0003-4819-148-11-200806030-00004

Perz, 2006, The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide, J Hepatol, 45, 529, 10.1016/j.jhep.2006.05.013

Gilbert, 2010, Genomic fossils calibrate the long-term evolution of hepadnaviruses, PLoS Biol, 8, e1000495, 10.1371/journal.pbio.1000495

Fares, 2002, A revised evolutionary history of hepatitis B virus (HBV), J Mol Evol, 54, 807, 10.1007/s00239-001-0084-z

Simmonds, 2001, Reconstructing the origins of human hepatitis viruses, Philos Trans R Soc Lond B Biol Sci, 356, 1013, 10.1098/rstb.2001.0890

Edmondson, 1954, Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies, Cancer, 7, 462, 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E

Higginson, 1957, Hepatic fibrosis and cirrhosis in man in relation to malnutrition, Am J Pathol, 33, 29

Edmondson, 1958

IARC, 1994

Parkin, 2005, Global cancer statistics, 2002, CA Cancer J Clin, 55, 74, 10.3322/canjclin.55.2.74

Schutte, 2009, Hepatocellular carcinoma–epidemiological trends and risk factors, Dig Dis, 27, 80, 10.1159/000218339

CDC

Beasley, 1981, Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan, Lancet, 2, 1129, 10.1016/S0140-6736(81)90585-7

Heyward, 1985, Early detection of primary hepatocellular carcinoma. Screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus, JAMA, 254, 3052, 10.1001/jama.1985.03360210068031

Evans, 2002, Eight-year follow-up of the 90,000-person Haimen City cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences, Cancer Epidemiol Biomarkers Prev, 11, 369

Chen, 2007, Long-term outcomes in hepatitis B: the REVEAL-HBV study, Clin Liver Dis, 11, 797, 10.1016/j.cld.2007.08.005

Ijima, 1984, A prospective cohort study of hepatitis B surface antigen carriers in a working population, Gann, 75, 571

Stevens, 1975, Vertical transmission of hepatitis B antigen in Taiwan, N Engl J Med, 292, 771, 10.1056/NEJM197504102921503

Okada, 1976, e Antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants, N Engl J Med, 294, 746, 10.1056/NEJM197604012941402

Marinier, 1985, Lack of perinatal transmission of hepatitis B virus infection in Senegal, West Africa, J Pediatr, 106, 843, 10.1016/S0022-3476(85)80371-1

Larouze, 1976, Host responses to hepatitis-B infection in patients with primary hepatic carcinoma and their families. A case/control study in Senegal, West Africa, Lancet, 2, 534, 10.1016/S0140-6736(76)91792-X

Hann, 1982, Hepatitis B virus and primary hepatocellular carcinoma: family studies in Korea, Int J Cancer, 30, 47, 10.1002/ijc.2910300109

Beasley, 1988, Hepatitis B virus. The major etiology of hepatocellular carcinoma, Cancer, 61, 1942, 10.1002/1097-0142(19880515)61:10<1942::AID-CNCR2820611003>3.0.CO;2-J

Shafritz, 1981, Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens, N Engl J Med, 305, 1067, 10.1056/NEJM198110293051807

Brechot, 1985, Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen, N Engl J Med, 312, 270, 10.1056/NEJM198501313120503

Ming, 2002, Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China, Hepatology, 36, 1214, 10.1053/jhep.2002.36366

Chen, 2006, Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study, Am J Gastroenterol, 101, 1797, 10.1111/j.1572-0241.2006.00647.x

Chen, 2009, Hepatitis B virus DNA levels and outcomes in chronic hepatitis B, Hepatology, 49, S72, 10.1002/hep.22884

McMahon, 2009, The natural history of chronic hepatitis B virus infection, Hepatology, 49, S45, 10.1002/hep.22898

McMahon, 2010, Natural history of chronic hepatitis B, Clin Liver Dis, 14, 381, 10.1016/j.cld.2010.05.007

Sumi, 2003, Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease, Hepatology, 37, 19, 10.1053/jhep.2003.50036

WHO

Chang, 2009, Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study, J Natl Cancer Inst, 101, 1348, 10.1093/jnci/djp288

Choo, 1989, Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome, Science, 244, 359, 10.1126/science.2523562

Simmonds, 2004, Genetic diversity and evolution of hepatitis C virus–15 years on, J Gen Virol, 85, 3173, 10.1099/vir.0.80401-0

Simmonds, 1993, Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region, J Gen Virol, 74, 2391, 10.1099/0022-1317-74-11-2391

Pybus, 2001, The epidemic behavior of the hepatitis C virus, Science, 292, 2323, 10.1126/science.1058321

Pybus, 2009, Genetic history of hepatitis C virus in East Asia, J Virol, 83, 1071, 10.1128/JVI.01501-08

Pybus, 2007, Investigating the endemic transmission of the hepatitis C virus, Int J Parasitol, 37, 839, 10.1016/j.ijpara.2007.04.009

Bostan, 2010, An overview about hepatitis C: a devastating virus, Crit Rev Microbiol, 36, 91, 10.3109/10408410903357455

Tanaka, 2002, Inaugural article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades, Proc Natl Acad Sci U S A, 99, 15584, 10.1073/pnas.242608099

Iida, 1999, Chronic Japanese schistosomiasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan, Bull World Health Organ, 77, 573

1984, Primary liver cancer in Japan. The Liver Cancer Study Group of Japan, Cancer, 54, 1747, 10.1002/1097-0142(19841015)54:8<1747::AID-CNCR2820540846>3.0.CO;2-L

Chung, 2010, Changing trends in hepatitis C infection over the past 50 years in Japan, Intervirology, 53, 39, 10.1159/000252782

Moriya, 1999, Epidemiology of hepatitis C virus in Japan, Intervirology, 42, 153, 10.1159/000024974

Frank, 2000, The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt, Lancet, 355, 887, 10.1016/S0140-6736(99)06527-7

Tanaka, 2004, Exponential spread of hepatitis C virus genotype 4a in Egypt, J Mol Evol, 58, 191, 10.1007/s00239-003-2541-3

Mizokami, 2005, Tracing the evolution of hepatitis C virus in the United States, Japan, and Egypt by using the molecular clock, Clin Gastroenterol Hepatol, 3, S82, 10.1016/S1542-3565(05)00705-6

Armstrong, 2000, The past incidence of hepatitis C virus infection: implications for the future burden of chronic liver disease in the United States, Hepatology, 31, 777, 10.1002/hep.510310332

Salomon, 2002, Empirically calibrated model of hepatitis C virus infection in the United States, Am J Epidemiol, 156, 761, 10.1093/aje/kwf100

Seeff, 2000, 45-year follow-up of hepatitis C virus infection in healthy young adults, Ann Intern Med, 132, 105, 10.7326/0003-4819-132-2-200001180-00003

IARC, 2002, vol. 2010

Ozturk, 1991, p53 mutation in hepatocellular carcinoma after aflatoxin exposure, Lancet, 338, 1356, 10.1016/0140-6736(91)92236-U

Bressac, 1991, Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa, Nature, 350, 429, 10.1038/350429a0

Hsu, 1991, Mutational hotspot in the p53 gene in human hepatocellular carcinomas, Nature, 350, 427, 10.1038/350427a0

Wild, 2000, Primary prevention of hepatocellular carcinoma in developing countries, Mutat Res, 462, 381, 10.1016/S1383-5742(00)00027-2

Plymoth, 2009, Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention, Cancer Lett, 286, 15, 10.1016/j.canlet.2009.08.024

Qian, 1994, A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China, Cancer Epidemiol Biomarkers Prev, 3, 3

Ross, 1992, Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma, Lancet, 339, 943, 10.1016/0140-6736(92)91528-G

Kuang, 2005, Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand, Cancer Epidemiol Biomarkers Prev, 14, 380, 10.1158/1055-9965.EPI-04-0380

Liu, 2010, Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment, Environ Health Perspect, 118, 818, 10.1289/ehp.0901388

Wild, 2010, Mycotoxins and human disease: a largely ignored global health issue, Carcinogenesis, 31, 71, 10.1093/carcin/bgp264

IARC, 1988

World Cancer Research Fund/American Institute for Cancer Research, 2007

Aizawa, 2000, Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis, Cancer, 89, 53, 10.1002/1097-0142(20000701)89:1<53::AID-CNCR8>3.0.CO;2-6

Corrao, 1999, Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis, Addiction, 94, 1551, 10.1046/j.1360-0443.1999.9410155111.x

Kono, 1987, Cigarette smoking, alcohol and cancer mortality: a cohort study of male Japanese physicians, Jpn J Cancer Res, 78, 1323

Hirayama, 1989, large-scale cohort study on risk factors for primary liver cancer, with special reference to the role of cigarette smoking, Cancer Chemother Pharmacol, 23, S114, 10.1007/BF00647254

Roudot-Thoraval, 1997, Epidemiological factors affecting the severity of hepatitis C virus-related liver disease: a French survey of 6,664 patients. The Study Group for the Prevalence and the Epidemiology of Hepatitis C Virus, Hepatology, 26, 485, 10.1002/hep.510260233

Shibata, 1986, The role of drinking and cigarette smoking in the excess deaths from liver cancer, Jpn J Cancer Res, 77, 287

Tanaka, 1988, Blood transfusion, alcohol consumption, and cigarette smoking in causation of hepatocellular carcinoma: a case-control study in Fukuoka, Japan, Jpn J Cancer Res, 79, 1075, 10.1111/j.1349-7006.1988.tb01529.x

Tsukuma, 1990, A case-control study of hepatocellular carcinoma in Osaka, Japan, Int J Cancer, 45, 231, 10.1002/ijc.2910450205

Ikeda, 1998, Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients, J Hepatol, 28, 930, 10.1016/S0168-8278(98)80339-5

Chen, 1991, Effects of hepatitis B virus, alcohol drinking, cigarette smoking and familial tendency on hepatocellular carcinoma, Hepatology, 13, 398, 10.1002/hep.1840130303

Oshima, 1984, Follow-up study of HBs Ag-positive blood donors with special reference to effect of drinking and smoking on development of liver cancer, Int J Cancer, 34, 775, 10.1002/ijc.2910340607

Lam, 1982, Hepatitis B virus and cigarette smoking: risk factors for hepatocellular carcinoma in Hong Kong, Cancer Res, 42, 5246

Lu, 1988, A case-control study of primary hepatocellular carcinoma in Taiwan, Cancer, 62, 2051, 10.1002/1097-0142(19881101)62:9<2051::AID-CNCR2820620930>3.0.CO;2-1

Goodman, 1995, Prospective cohort study of risk factors for primary liver cancer in Hiroshima and Nagasaki, Japan, Epidemiology, 6, 36, 10.1097/00001648-199501000-00008

Yu, 1997, Prospective study of hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B virus carriers, Am J Epidemiol, 145, 1039, 10.1093/oxfordjournals.aje.a009060

Donato, 2002, Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women, Am J Epidemiol, 155, 323, 10.1093/aje/155.4.323

Kuper, 2000, Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma, Int J Cancer, 85, 498, 10.1002/(SICI)1097-0215(20000215)85:4<498::AID-IJC9>3.0.CO;2-F

Yuan, 2004, Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S, Cancer, 101, 1009, 10.1002/cncr.20427

Frezza, 1990, High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism, N Engl J Med, 322, 95, 10.1056/NEJM199001113220205

Tuyns, 1984, Greater risk of ascitic cirrhosis in females in relation to alcohol consumption, Int J Epidemiol, 13, 53, 10.1093/ije/13.1.53

Corrao, 1997, Female sex and the risk of liver cirrhosis. Collaborative groups for the study of liver diseases in Italy, Scand J Gastroenterol, 32, 1174, 10.3109/00365529709002999

Mukaiya, 1998, Chronic liver diseases for the risk of hepatocellular carcinoma: a case-control study in Japan. Etiologic association of alcohol consumption, cigarette smoking and the development of chronic liver diseases, Hepatogastroenterology, 45, 2328

Hassan, 2008, Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study, Int J Cancer, 123, 1883, 10.1002/ijc.23730

Hart, 2010, Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies, BMJ, 340, c1240, 10.1136/bmj.c1240

Flegal, 2010, Prevalence and trends in obesity among US adults, 1999–2008, JAMA, 303, 235, 10.1001/jama.2009.2014

McKillop, 2009, Role of alcohol in liver carcinogenesis, Semin Liver Dis, 29, 222, 10.1055/s-0029-1214377

Seitz, 1998, Alcohol and cancer, Recent Dev Alcohol, 14, 67, 10.1007/0-306-47148-5_4

WHO

Lawson, 1986, Diabetes mellitus and primary hepatocellular carcinoma, Q J Med, 61, 945

Kessler, 1970, Cancer mortality among diabetics, J Natl Cancer Inst, 44, 673

Ragozzino, 1982, Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus, J Chronic Dis, 35, 13, 10.1016/0021-9681(82)90025-X

El-Serag, 2001, The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans, Am J Gastroenterol, 96, 2462, 10.1111/j.1572-0241.2001.04054.x

Hadziyannis, 1995, A case-control study of hepatitis B and C virus infections in the etiology of hepatocellular carcinoma, Int J Cancer, 60, 627, 10.1002/ijc.2910600510

Beasley, 2006, Diabetes and hepatocellular carcinoma, Hepatology, 44, 1408, 10.1002/hep.21430

Gao, 2009, Diabetes mellitus: a "true" independent risk factor for hepatocellular carcinoma?, Hepatobiliary Pancreat Dis Int, 8, 465

El-Serag, 2006, The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence, Clin Gastroenterol Hepatol, 4, 369, 10.1016/j.cgh.2005.12.007

Adami, 1991, Cancer risk in patients with diabetes mellitus, Cancer Causes Control, 2, 307, 10.1007/BF00051670

Koskinen, 1998, Mortality in a large population-based cohort of patients with drug-treated diabetes mellitus, Am J Public Health, 88, 765, 10.2105/AJPH.88.5.765

Weiderpass, 2001, Cause-specific mortality in a cohort of patients with diabetes mellitus: a population-based study in Sweden, J Clin Epidemiol, 54, 802, 10.1016/S0895-4356(01)00342-0

Sasaki, 1997, 15-year follow-up study of patients with non-insulin-dependent diabetes mellitus (NIDDM) in Osaka, Japan. Factors predictive of the prognosis of diabetic patients, Diabetes Res Clin Pract, 36, 41, 10.1016/S0168-8227(97)00026-0

Adami, 1996, Excess risk of primary liver cancer in patients with diabetes mellitus, J Natl Cancer Inst, 88, 1472, 10.1093/jnci/88.20.1472

Wideroff, 1997, Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark, J Natl Cancer Inst, 89, 1360, 10.1093/jnci/89.18.1360

Balkau, 2001, Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: the Paris Prospective Study, Diabetes Care, 24, 843, 10.2337/diacare.24.5.843

Clark, 2002, Hepatic steatosis and type 2 diabetes mellitus, Curr Diab Rep, 2, 210, 10.1007/s11892-002-0085-3

Mason, 1999, Association of diabetes mellitus and chronic hepatitis C virus infection, Hepatology, 29, 328, 10.1002/hep.510290235

Petrides, 1989, Glucose and insulin metabolism in cirrhosis, J Hepatol, 8, 107, 10.1016/0168-8278(89)90169-4

Hassan, 2002, Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus, Hepatology, 36, 1206, 10.1053/jhep.2002.36780

Lagiou, 2000, Role of diabetes mellitus in the etiology of hepatocellular carcinoma, J Natl Cancer Inst, 92, 1096, 10.1093/jnci/92.13.1096

Nguyen, 2011, Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999–2006, Obes Surg, 21, 351, 10.1007/s11695-010-0335-4

Saunders, 2010, Systematic review: the association between obesity and hepatocellular carcinoma - epidemiological evidence, Aliment Pharmacol Ther, 31, 1051, 10.1111/j.1365-2036.2010.04271.x

Larsson, 2007, Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies, Br J Cancer, 97, 1005, 10.1038/sj.bjc.6603932

Shaw, 2010, Global estimates of the prevalence of diabetes for 2010 and 2030, Diabetes Res Clin Pract, 87, 4, 10.1016/j.diabres.2009.10.007

James, 2008, The epidemiology of obesity: the size of the problem, J Intern Med, 263, 336, 10.1111/j.1365-2796.2008.01922.x

Flegal, 1998, Overweight and obesity in the United States: prevalence and trends, 1960–1994, Int J Obes Relat Metab Disord, 22, 39, 10.1038/sj.ijo.0800541

Flegal, 2002, Prevalence and trends in obesity among US adults, 1999–2000, JAMA, 288, 1723, 10.1001/jama.288.14.1723

Ludwig, 1980, Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease, Mayo Clin Proc, 55, 434

Brunt, 1999, Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions, Am J Gastroenterol, 94, 2467, 10.1111/j.1572-0241.1999.01377.x

Byron, 1996, Clinical hepatology: profile of an urban, hospital-based practice, Hepatology, 24, 813, 10.1002/hep.510240410

Farrell, 2003, Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?, J Gastroenterol Hepatol, 18, 124, 10.1046/j.1440-1746.2003.02989.x

Bacon, 1994, Nonalcoholic steatohepatitis: an expanded clinical entity, Gastroenterology, 107, 1103, 10.1016/0016-5085(94)90235-6

Struben, 2000, Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds, Am J Med, 108, 9, 10.1016/S0002-9343(99)00315-0

Bugianesi, 2002, Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma, Gastroenterology, 123, 134, 10.1053/gast.2002.34168

Caldwell, 1999, Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease, Hepatology, 29, 664, 10.1002/hep.510290347

Poonawala, 2000, Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study, Hepatology, 32, 689, 10.1053/jhep.2000.17894

Powell, 1990, The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years, Hepatology, 11, 74, 10.1002/hep.1840110114

Schafer, 1999, Hepatocellular carcinoma, Lancet, 353, 1253, 10.1016/S0140-6736(98)09148-X

Cotrim, 2000, Nonalcoholic steatohepatitis and hepatocellular carcinoma: natural history?, Am J Gastroenterol, 95, 3018, 10.1111/j.1572-0241.2000.03241.x

Shimada, 2002, Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis, J Hepatol, 37, 154, 10.1016/S0168-8278(02)00099-5

Zen, 2001, Hepatocellular carcinoma arising in non-alcoholic steatohepatitis, Pathol Int, 51, 127, 10.1046/j.1440-1827.2001.01174.x

Sorensen, 2003, Risk of cancer in patients hospitalized with fatty liver: a Danish cohort study, J Clin Gastroenterol, 36, 356, 10.1097/00004836-200304000-00015

Ertle, 2011, Nonalcoholic fatty liver disease progresses to HCC in the absence of apparent cirrhosis, Int J Cancer, 128, 2436, 10.1002/ijc.25797

Sanyal, 2010, Population-based risk factors and resource utilization for HCC: US perspective, Curr Med Res Opin, 26, 2183, 10.1185/03007995.2010.506375