The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species

Aguilar-Zapata, 2015, Echinocandins: the expanding antifungal armamentarium., Clin. Infect. Dis., 61, S604, 10.1093/cid/civ814

Agustinho, 2018, Peeling the onion: the outer layers of Cryptococcus neoformans., Mem. Inst. Oswaldo. Cruz., 113, 10.1590/0074-02760180040

Aimanianda, 2009, Surface hydrophobin prevents immune recognition of airborne fungal spores., Nature, 460, 1117, 10.1038/nature08264

Aimanianda, 2017, The dual activity responsible for the elongation and branching of beta-(1,3)-glucan in the fungal cell wall., mBio, 8, 10.1128/mBio.00619-17

Amin, 2014, Melanin dependent survival of Apergillus fumigatus conidia in lung epithelial cells., Int. J. Med. Microbiol., 304, 626, 10.1016/j.ijmm.2014.04.009

Aruanno, 2019, Echinocandins for the treatment of invasive aspergillosis: from laboratory to bedside., Antimicrob. Agents Chemother., 63, 10.1128/AAC.00399-19

Bain, 2014, Candida albicans hypha formation and mannan masking of beta-glucan inhibit macrophage phagosome maturation., mBio, 5, 10.1128/mBio.01874-14

Baker, 2007, Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans., Eukaryot. Cell, 6, 855, 10.1128/ec.00399-06

Baker, 2011, Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans., Eukaryot. Cell, 10, 1264, 10.1128/EC.05138-11

Banks, 2005, A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans., Eukaryot. Cell, 4, 1902, 10.1128/ec.4.11.1902-1912.2005

Bayry, 2014, Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response., Infect. Immun., 82, 3141, 10.1128/IAI.01726-14

Beardsley, 2019, Central nervous system cryptococcal infections in Non-HIV infected patients., J Fungi, 5, 10.3390/jof5030071

Beauvais, 2013, Deletion of the alpha-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus., PLoS Pathog., 9, 10.1371/journal.ppat.1003716

Beauvais, 2001, Glucan synthase complex of Aspergillus fumigatus., J. Bacteriol., 183, 2273, 10.1128/jb.183.7.2273-2279.2001

Beauvais Anne, 2006, Role of α(1-3) glucan in aspergillus fumigatus and other human fungal pathogens., Fungi Environ., 269, 10.1017/CBO9780511541797.014

Becker, 2016, Aspergillus cell wall chitin induces anti- and proinflammatory cytokines in Human PBMCs via the Fc-gamma receptor/Syk/PI3K Pathway., mBio, 7, 10.1128/mBio.01823-15

Bowman, 2006, The structure and synthesis of the fungal cell wall., Bioessays, 28, 799, 10.1002/bies.20441

Boxx, 2010, Influence of mannan and glucan on complement activation and C3 binding by Candida albicans., Infect. Immun., 78, 1250, 10.1128/IAI.00744-09

Boxx, 2009, Characteristics of Fc-independent human antimannan antibody-mediated alternative pathway initiation of C3 deposition to Candida albicans., Mol. Immunol., 46, 473, 10.1016/j.molimm.2008.10.008

Bozza, 2009, Immune sensing of Aspergillus fumigatus proteins, glycolipids, and polysaccharides and the impact on Th immunity and vaccination., J. Immunol., 183, 2407, 10.4049/jimmunol.0900961

Braun, 1978, Chitin synthesis in Candida albicans: comparison of yeast and hyphal forms., J. Bacteriol., 133, 1472, 10.1128/JB.133.3.1472-1477.1978

Brown, 2005, Immune recognition of fungal beta-glucans., Cell Microbiol., 7, 471, 10.1111/j.1462-5822.2005.00505.x

Brown, 2002, Dectin-1 is a major beta-glucan receptor on macrophages., J. Exp. Med., 196, 407, 10.1084/jem.20020470

Bulawa, 1995, Attenuated virulence of chitin-deficient mutants of Candida albicans., Proc. Natl. Acad. Sci. U.S.A., 92, 10570, 10.1073/pnas.92.23.10570

Camacho, 2017, N-acetylglucosamine affects Cryptococcus neoformans cell-wall composition and melanin architecture., Microbiology, 163, 1540, 10.1099/mic.0.000552

Carrion Sde, 2013, The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo., J. Immunol., 191, 2581, 10.4049/jimmunol.1300748

Casadevall, 2018, The capsule of Cryptococcus neoformans., Virulence, 1431087, 1, 10.1080/21505594.2018

Casadevall, 1998, Cryptococcus Neoformans., 10.1128/9781555818241

Casadevall, 2000, Melanin and virulence in Cryptococcus neoformans., Curr. Opin. Microbiol., 3, 354, 10.1016/s1369-5274(00)00103-x

Chaffin, 2008, Candida albicans cell wall proteins., Microbiol. Mol. Biol. Rev., 72, 495, 10.1128/MMBR.00032-07

Chantal, 2016, The importance of subclasses of chitin synthaseenzymes with myosin-like domains for the fitnessof fungi., Br. Mycol. Soc., 30, 1, 10.1016/j.fbr.2016.03.002

Chattaway, 1968, Cell wall composition of the mycelial and blastospore forms of Candida albicans., J. Gen. Microbiol., 51, 367, 10.1099/00221287-51-3-367

Chayakulkeeree, 2011, SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans., Mol. Microbiol., 80, 1088, 10.1111/j.1365-2958.2011.07632.x

Cortes, 2019, The fungal cell wall as a target for the development of new antifungal therapies., Biotechnol. Adv., 37, 10.1016/j.biotechadv.2019.02.008

Costachel, 2005, Glycosylphosphatidylinositol-anchored fungal polysaccharide in Aspergillus fumigatus., J. Biol. Chem., 280, 39835, 10.1074/jbc.m510163200

Da Silva, 2009, Chitin is a size-dependent regulator of macrophage TNF and IL-10 production., J. Immunol., 182, 3573, 10.4049/jimmunol.0802113

Dambuza, 2018, The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis., PLoS Pathog., 14, 10.1371/journal.ppat.1006978

de Groot, 2008, The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins., Eukaryot. Cell, 7, 1951, 10.1128/EC.00284-08

Del Palacio, 2009, [Epidemiology of invasive candidiasis in pediatric and adult populations]., Rev. Iberoam. Micol., 26, 2, 10.1016/S1130-1406(09)70002-6

Dichtl, 2012, Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional characterization of cell wall stress sensors and relevant Rho GTPases., Mol. Microbiol., 83, 506, 10.1111/j.1365-2958.2011.07946.x

Dichtl, 2015, Aspergillus fumigatus devoid of cell wall beta-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors., Mol. Microbiol., 95, 458, 10.1111/mmi.12877

Ding, 2016, Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans., F1000Res, 5, 10.12688/f1000research.8854.1

Doblin, 2009, A barley cellulose synthase-like CSLH gene mediates (1,3;1,4)-beta-D-glucan synthesis in transgenic Arabidopsis., Proc. Natl. Acad. Sci. U.S.A., 106, 5996, 10.1073/pnas.0902019106

Doering, 2009, How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans., Annu. Rev. Microbiol., 63, 223, 10.1146/annurev.micro.62.081307.162753

Douglas, 1994, The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase., Proc. Natl. Acad. Sci. U.S.A., 91, 12907, 10.1073/pnas.91.26.12907

Eigenheer, 2007, Extracellular glycosylphosphatidylinositol-anchored mannoproteins and proteases of Cryptococcus neoformans., FEMS Yeast Res., 7, 499, 10.1111/j.1567-1364.2006.00198.x

Eisenman, 2012, Synthesis and assembly of fungal melanin., Appl. Microbiol. Biotechnol., 93, 931, 10.1007/s00253-011-3777-2

Erwig, 2016, Interactions of fungal pathogens with phagocytes., Nat. Rev. Microbiol., 14, 163, 10.1038/nrmicro.2015.21

Evans, 2015, Cryptococcal phospholipase B1 is required for intracellular proliferation and control of titan cell morphology during macrophage infection., Infect. Immun., 83, 1296, 10.1128/IAI.03104-14

Fonseca, 2009, Role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans., Eukaryot. Cell, 8, 1543, 10.1128/EC.00142-09

Fonseca, 2018, The overlooked glycan components of the cryptococcus capsule., Curr. Top. Microbiol. Immunol., 422, 31, 10.1007/82_2018_140

Fontaine, 2011, Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus., PLoS Pathog., 7, 10.1371/journal.ppat.1002372

Fontaine, 2000, Molecular organization of the alkali-insoluble fraction of Aspergillus fumigatus cell wall., J. Biol. Chem., 275, 27594, 10.1074/jbc.M909975199

Free, 2013, Fungal cell wall organization and biosynthesis., Adv. Genet., 81, 33, 10.1016/B978-0-12-407677-8.00002-6

Galan-Diéz, 2010, Candida albicans beta-glucan exposure is controlled by the fungal CEK1-mediated mitogen-activated protein kinase pathway that modulates immune responses triggered through dectin-1., Infect. Immun., 78, 1426, 10.1128/IAI.00989-09

Garcia-Rodas, 2018, Cryptococcal titan cells: when yeast cells are all grown up., Curr. Top. Microbiol. Immunol., 422, 101, 10.1007/82_2018_145

Garcia-Rubio, 2017, Triazole resistance in Aspergillus species: an emerging problem., Drugs, 77, 599, 10.1007/s40265-017-0714-4

Gastebois, 2010, beta(1-3)Glucanosyltransferase Gel4p is essential for Aspergillus fumigatus., Eukaryot. Cell, 9, 1294, 10.1128/EC.00107-10

Gessner, 2012, Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus., Infect. Immun., 80, 410, 10.1128/IAI.05939-11

Ghannoum, 2018, Evaluation of the antifungal activity of the novel oral glucan synthase inhibitor SCY-078, singly and in combination, for the treatment of invasive Aspergillosis., Antimicrob. Agents Chemother., 62, 10.1128/AAC.00244-18

Gilbert, 2010, KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans., Mol. Microbiol., 76, 517, 10.1111/j.1365-2958.2010.07119.x

Gow, 2012, Importance of the Candida albicans cell wall during commensalism and infection., Curr. Opin Microbiol., 15, 406, 10.1016/j.mib.2012.04.005

Gow, 2017, The fungal cell wall: structure, biosynthesis, and function., Microbiol. Spectr., 5, 10.1128/microbiolspec.FUNK-0035-2016

Granger, 2018, Accessibility and contribution to glucan masking of natural and genetically tagged versions of yeast wall protein 1 of Candida albicans., PLoS One, 13, 10.1371/journal.pone.0191194

Gravelat, 2013, Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal beta-glucan from the immune system., PLoS Pathog., 9, 10.1371/journal.ppat.1003575

Gresnigt, 2014, A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist., PLoS Pathog., 10, 10.1371/journal.ppat.1003936

Heitman, 2005, Cell biology. A fungal Achilles’ heel., Science, 309, 2175, 10.1126/science.1119321

Henry, 2016, Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus., Cell Microbiol., 18, 1881, 10.1111/cmi.12665

Henry, 2019, Two KTR mannosyltransferases are responsible for the biosynthesis of cell wall mannans and control polarized growth in Aspergillus fumigatus., mBio, 10, 10.1128/mBio.02647-18

Hernandez-Chavez, 2017, Fungal strategies to evade the host immune recognition., J. Fungi, 3, 10.3390/jof3040051

Herre, 2004, The role of Dectin-1 in antifungal immunity., Crit. Rev. Immunol., 24, 193, 10.1615/CritRevImmunol.v24.i3.30

Hommel, 2018, Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators., PLoS Pathog., 14, 10.1371/journal.ppat.1006982

Jacobson, 2005, Effect of melanization upon porosity of the cryptococcal cell wall., Med. Mycol., 43, 327, 10.1080/13693780412331271081

Kanetsuna, 1969, Cell wall composition of the yeast and mycelial forms of Paracoccidioides brasiliensis., J. Bacteriol., 97, 1036, 10.1128/JB.97.3.1036-1041.1969

Klis, 2001, Molecular organization of the cell wall of Candida albicans., Med. Mycol., 39, 1, 10.1080/714868561

Kobayashi, 1998, Structural and immunochemical characterization of beta-1,2-linked mannobiosyl phosphate residue in the cell wall mannan of Candida glabrata., Arch. Microbiol., 169, 188, 10.1007/s002030050559

Koneti, 2008, Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis., Infect. Immun., 76, 994, 10.1128/iai.01185-07

Krishnan, 2017, CD101, a novel echinocandin with exceptional stability properties and enhanced aqueous solubility., J. Antibiot., 70, 130, 10.1038/ja.2016.89

Larkin, 2019, A Novel 1,3-Beta-d-Glucan Inhibitor, Ibrexafungerp (Formerly SCY-078), shows potent activity in the lower ph environment of Vulvovaginitis., Antimicrob. Agents Chemother., 63, 10.1128/AAC.02611-18

Latge, 1999, Aspergillus fumigatus and aspergillosis., Clin. Microbiol. Rev., 12, 310, 10.1128/CMR.12.2.310

Lee, 2012, Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo., Antimicrob. Agents Chemother., 56, 208, 10.1128/AAC.00683-11

Lee, 2016, Recent advances in the understanding of the Aspergillus fumigatus cell wall., J. Microbiol., 54, 232, 10.1007/s12275-016-6045-4

Lesage, 2006, Cell wall assembly in Saccharomyces cerevisiae., Microbiol. Mol. Biol. Rev., 70, 317, 10.1128/mmbr.00038-05

Levitz, 2017, Aspergillus vaccines: hardly worth studying or worthy of hard study?, Med. Mycol., 55, 103, 10.1093/mmy/myw081

Lima-Neto, 2011, Adherence of Candida albicans and Candida parapsilosis to epithelial cells correlates with fungal cell surface carbohydrates., Mycoses, 54, 23, 10.1111/j.1439-0507.2009.01757.x

Liu, 1999, Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages., Infect. Immun., 67, 6034, 10.1128/IAI.67.11.6034-6039.1999

Loures, 2015, Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps., PLoS Pathog., 11, 10.1371/journal.ppat.1004643

Maligie, 2005, Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins., Antimicrob. Agents Chemother., 49, 2851, 10.1128/aac.49.7.2851-2856.2005

Maruvada, 2012, Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier., Cell Microbiol., 14, 1544, 10.1111/j.1462-5822.2012.01819.x

Maziarz, 2016, Cryptococcosis., Infect. Dis. Clin. North Am., 30, 179, 10.1016/j.idc.2015.10.006

Mazur, 1995, Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase., Mol. Cell Biol., 15, 5671, 10.1128/mcb.15.10.5671

McFadden, 2001, Capsule and melanin synthesis in Cryptococcus neoformans., Med. Mycol., 39, 19, 10.1080/714031007

Mednick, 2005, Melanization of Cryptococcus neoformans affects lung inflammatory responses during cryptococcal infection., Infect. Immun., 73, 2012, 10.1128/iai.73.4.2012-2019.2005

Mora-Montes, 2011, Recognition and blocking of innate immunity cells by Candida albicans chitin., Infect. Immun., 79, 1961, 10.1128/IAI.01282-10

Mouyna, 2013, beta-1,3-glucan modifying enzymes in Aspergillus fumigatus., Front. Microbiol., 4, 10.3389/fmicb.2013.00081

Mukaremera, 2018, Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection., Cell Surf., 1, 15, 10.1016/j.tcsw.2017.12.001

Munro, 2001, Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity., Mol. Microbiol., 39, 1414, 10.1046/j.1365-2958.2001.02347.x

Muszkieta, 2014, Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion., Cell Microbiol., 16, 1784, 10.1111/cmi.12326

Muszkieta, 2019, The glycosylphosphatidylinositol-anchored DFG family is essential for the insertion of galactomannan into the beta-(1,3)-glucan-chitin core of the cell wall of Aspergillus fumigatus., mSphere, 4, 10.1128/mSphere.00397-19

Nosanchuk, 2006, Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds., Antimicrob. Agents Chemother., 50, 3519, 10.1128/aac.00545-06

Nosanchuk, 2015, Fungal melanin: what do we know about structure?, Front. Microbiol., 6, 10.3389/fmicb.2015.01463

Noverr, 2004, CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence., Infect. Immun., 72, 1693, 10.1128/iai.72.3.1693-1699.2004

Okagaki, 2010, Cryptococcal cell morphology affects host cell interactions and pathogenicity., PLoS Pathog., 6, 10.1371/journal.ppat.1000953

O’Meara, 2012, The Cryptococcus neoformans capsule: a sword and a shield., Clin. Microbiol. Rev., 25, 387, 10.1128/CMR.00001-12

Paulovicova, 2015, Immune cell response to Candida cell wall mannan derived branched alpha-oligomannoside conjugates in mice., J. Microbiol. Immunol. Infect., 48, 9, 10.1016/j.jmii.2013.08.020

Pazos, 2006, Diagnostic potential of (1,3)-beta-D-glucan and anti-Candida albicans germ tube antibodies for the diagnosis and therapeutic monitoring of invasive candidiasis in neutropenic adult patients., Rev. Iberoam. Micol., 23, 209, 10.1016/S1130-1406(06)70046-8

Pfuller, 2011, A novel flucytosine-resistant yeast species, Candida pseudoaaseri, causes disease in a cancer patient., J. Clin. Microbiol., 49, 4195, 10.1128/JCM.05090-11

Ponton, 2008, [The fungal cell wall and the mechanism of action of anidulafungin]., Rev. Iberoam. Micol., 25, 78

Poulain, 2004, Candida albicans cell wall glycans, host receptors and responses: elements for a decisive crosstalk., Curr. Opin. Microbiol., 7, 342, 10.1016/j.mib.2004.06.011

Qadota, 1996, Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase., Science, 272, 279, 10.1126/science.272.5259.279

Rajasingham, 2017, Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis., Lancet Infect. Dis., 17, 873, 10.1016/S1473-3099(17)30243-8

Rambach, 2015, Identification of Aspergillus fumigatus surface components that mediate interaction of conidia and hyphae with human platelets., J. Infect. Dis., 212, 1140, 10.1093/infdis/jiv191

Rappleye, 2007, Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor., Proc. Natl. Acad. Sci. U.S.A., 104, 1366, 10.1073/pnas.0609848104

Reese, 2003, Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule., Mol. Microbiol., 50, 1401, 10.1046/j.1365-2958.2003.03780.x

Reese, 2007, Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence., Mol. Microbiol., 63, 1385, 10.1111/j.1365-2958.2006.05551.x

Rivera, 2011, Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation., J. Exp. Med., 208, 369, 10.1084/jem.20100906

Robinet, 2014, A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells., J. Immunol., 192, 5332, 10.4049/jimmunol.1303180

Rosa, 2010, Endophytic fungi community associated with the dicotyledonous plant Colobanthus quitensis (Kunth) Bartl. (Caryophyllaceae) in Antarctica., FEMS Microbiol. Ecol., 73, 178, 10.1111/j.1574-6941.2010.00872.x

Rubin-Bejerano, 2007, Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component., Cell Host Microbe, 2, 55, 10.1016/j.chom.2007.06.002

Sakaguchi, 1993, Ultrastructural study of Cryptococcus neoformans by quick-freezing and deep-etching method., Mycopathologia, 121, 133, 10.1007/bf01104068

Salas, 1996, Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans., J. Exp. Med., 184, 377, 10.1084/jem.184.2.377

Samar, 2015, Identification and deletion of Tft1, a predicted glycosyltransferase necessary for cell wall beta-1,3;1,4-glucan synthesis in Aspergillus fumigatus., PLoS One, 10, 10.1371/journal.pone.0117336

San-Blas, 1977, Paracoccidioides brasiliensis: cell wall structure and virulence. A review., Mycopathologia, 62, 77, 10.1007/bf01259396

Santangelo, 2004, Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model., Infect. Immun., 72, 2229, 10.1128/iai.72.4.2229-2239.2004

Sawistowska-Schroder, 1984, Echinocandin inhibition of 1,3-beta-D-glucan synthase from Candida albicans., FEBS Lett., 173, 134, 10.1016/0014-5793(84)81032-7

Scorneaux, 2017, SCY-078 is fungicidal against candida species in time-kill studies., Antimicrob. Agents Chemother., 61, 10.1128/AAC.01961-16

Sem, 2016, beta-glucan exposure on the fungal cell wall tightly correlates with competitive fitness of Candida species in the mouse gastrointestinal tract., Front. Cell Infect. Microbiol., 6, 10.3389/fcimb.2016.00186

Serrano-Gomez, 2004, Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages., J. Immunol., 173, 5635, 10.4049/jimmunol.173.9.5635

Shibata, 2012, Immunochemistry of pathogenic yeast, Candida species, focusing on mannan., Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 88, 250, 10.2183/pjab.88.250

Shibata, 2007, Chemical structure of the cell-wall mannan of Candida albicans serotype A and its difference in yeast and hyphal forms., Biochem. J., 404, 365, 10.1042/bj20070081

Siafakas, 2007, Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity., J. Biol. Chem., 282, 37508, 10.1074/jbc.m707913200

Silva, 2009, Resistance of melanized yeast cells of Paracoccidioides brasiliensis to antimicrobial oxidants and inhibition of phagocytosis using carbohydrates and monoclonal antibody to CD18., Mem. Inst. Oswaldo Cruz., 104, 644, 10.1590/s0074-02762009000400019

Silva, 2012, Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance., FEMS Microbiol. Rev., 36, 288, 10.1111/j.1574-6976.2011.00278.x

Snarr, 2017, Immune recognition of fungal polysaccharides., J. Fungi, 3, 10.3390/jof3030047

Sobel, 2007, Vulvovaginal candidosis., Lancet, 369, 1961, 10.1016/S0140-6736(07)60917-9

Thompson, 1999, A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function., J. Bacteriol., 181, 444, 10.1128/JB.181.2.444-453.1999

Toh, 2017, Creation, characterization and utilization of Cryptococcus neoformans mutants sensitive to micafungin., Curr. Genet., 63, 1093, 10.1007/s00294-017-0713-8

Torosantucci, 2005, A novel glyco-conjugate vaccine against fungal pathogens., J. Exp. Med., 202, 597, 10.1084/jem.20050749

Trevijano-Contador, 2018, Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals., PLoS Pathog., 14, 10.1371/journal.ppat.1007007

Tsui, 2016, Pathogenesis of Candida albicans biofilm., Pathog. Dis., 74, 10.1093/femspd/ftw018

Upadhya, 2016, Induction of protective immunity to cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans., mBio, 7, 10.1128/mBio.00547-16

Vecchiarelli, 2000, Immunoregulation by capsular components of Cryptococcus neoformans., Med. Mycol., 38, 407, 10.1080/714030973

Volling, 2011, Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling., Cell Microbiol., 13, 1130, 10.1111/j.1462-5822.2011.01605.x

Wagener, 2017, Candida albicans chitin increases Arginase-1 activity in human macrophages, with an impact on macrophage antimicrobial functions., mBio, 8, 10.1128/mBio.01820-16

Walker, 2013, Elevated chitin content reduces the susceptibility of Candida species to caspofungin., Antimicrob. Agents Chemother., 57, 146, 10.1128/AAC.01486-12

Wang, 1995, Cryptococcus neoformans melanin and virulence: mechanism of action., Infect. Immun., 63, 3131, 10.1128/IAI.63.8.3131-3136.1995

Wang, 2018, Unraveling synthesis of the cryptococcal cell wall and capsule., Glycobiology, 28, 719, 10.1093/glycob/cwy030

Werner, 2009, Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus., J. Immunol., 182, 4938, 10.4049/jimmunol.0804250

Wiederhold, 2018, Rezafungin (CD101) demonstrates potent in vitro activity against Aspergillus, including azole-resistant Aspergillus fumigatus isolates and cryptic species., J. Antimicrob. Chemother., 73, 3063, 10.1093/jac/dky280

Wiesner, 2015, Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection., PLoS Pathog., 11, 10.1371/journal.ppat.1004701

Yoshimi, 2017, Function and biosynthesis of cell Wall alpha-1,3-glucan in fungi., J. Fungi, 3, 10.3390/jof3040063

Zalar, 2011, Dishwashers–a man-made ecological niche accommodating human opportunistic fungal pathogens., Fungal Biol., 115, 997, 10.1016/j.funbio.2011.04.007

Zaragoza, 2019, Basic principles of the virulence of Cryptococcus., Virulence, 10, 490, 10.1080/21505594.2019.1614383

Zaragoza, 2008, Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival., Cell Microbiol., 10, 2043, 10.1111/j.1462-5822.2008.01186.x

Zaragoza, 2010, Fungal cell gigantism during mammalian infection., PLoS Pathog., 6, 10.1371/journal.ppat.1000945

Zaragoza, 2009, The capsule of the fungal pathogen Cryptococcus neoformans., Adv. Appl. Microbiol., 68, 133, 10.1016/S0065-2164(09)01204-0

Zhang, 1997, Mannan-specific immunoglobulin G antibodies in normal human serum mediate classical pathway initiation of C3 binding to Candida albicans., Infect. Immun., 65, 3822, 10.1128/IAI.65.9.3822-3827.1997