The Functional Neuroanatomy of Temporal Discrimination

Journal of Neuroscience - Tập 24 Số 10 - Trang 2585-2591 - 2004
María A. Pastor1, Brian L. Day2, Emiliano Macaluso3, Karl Friston2, R. S. J. Frackowiak3
1Department of Neurology, University of Navarre School of Medicine, Clinica Universitaria, 31080 Pamplona, Spain.
2University College London
3Fondazione Santa Lucia

Tóm tắt

Two identical stimuli, such as a pair of electrical shocks to the skin, are readily perceived as two separate events in time provided the interval between them is sufficiently long. However, as they are presented progressively closer together, there comes a point when the two separate stimuli are perceived as a single stimulus. Damage to posterior parietal cortex, peri-supplementary motor area (peri-SMA), and basal ganglia can disturb this form of temporal discrimination. Our aim was to establish, in healthy subjects, the brain areas that are involved in this process. During functional magnetic resonance imaging scanning, paired electrical pulses, separated by variable inter-stimulus intervals (5-110 msec), were delivered to different sites on one forearm (8-64 mm from the midline). Subjects were required to simply detect the stimulus (control task) or to identify a stimulus property. For temporal discrimination (TD), subjects reported whether they felt one or two stimuli. For spatial discrimination, they reported whether the stimuli were located on the right or left side of the forearm. Subjects reported their choice by pressing a button with the opposite hand. Our results showed that discrimination, as opposed to simply detection, activated several brain areas. Most were common to both discrimination tasks. These included regions of prefrontal cortex, right postcentral gyrus and inferior parietal lobule, basal ganglia, and cerebellum. However, activation of pre-SMA and anterior cingulate was found to be specific to the TD task. This suggests that these two frontal regions may play a role in the temporal processing of somatosensory events.

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Tài liệu tham khảo

10.1093/brain/115.1.199

2000, Neurology, 55, 1869, 10.1212/WNL.55.12.1869

1997, Int Rev Neurobiol, 41, 489, 10.1016/S0074-7742(08)60367-0

10.1093/cercor/9.7.662

10.1038/373249a0

10.1016/S1053-8119(03)00159-9

2002, J Neurophysiol, 87, 2158, 10.1152/jn.00867.2001

1996, Science, 272, 545, 10.1126/science.272.5261.545

10.1006/nimg.2001.1037

10.1016/S0959-4388(97)80005-0

10.1093/brain/115.2.565

1998, J Neurosci, 18, 1085, 10.1523/JNEUROSCI.18-03-01085.1998

2002, J Neurophysiol, 88, 1400, 10.1152/jn.2002.88.3.1400

10.1016/S0896-6273(02)00613-X

10.1016/0168-0102(96)01045-0

10.1016/S0006-8993(99)01531-0

10.1016/S0959-4388(96)80037-7

1990, J Neurosci, 10, 2066, 10.1523/JNEUROSCI.10-07-02066.1990

1995, Neurology, 45, 1540, 10.1212/WNL.45.8.1540

10.1093/cercor/7.5.465

10.1136/jnnp.54.12.1077

2003, Representation of time by neurons in the posterior parietal cortex of the macaque neuron, 38, 317

10.1002/1097-0193(200008)10:4<147::AID-HBM10>3.0.CO;2-U

10.1002/cne.10087

10.1007/s00221-001-0953-0

10.1006/nimg.1996.0014

10.1006/brcg.2001.1313

10.1002/ana.410290418

2001, J Neurosci, 21, 700, 10.1523/JNEUROSCI.21-02-00700.2001

10.1093/cercor/12.9.926

10.1093/brain/awg046

10.1007/s00221-003-1447-z

1993, Handbook of neurophysiolgy, IV, 339

10.1016/S0166-2236(03)00054-7

10.1016/0165-0173(94)00008-D

10.1101/lm.4.1.49

10.1093/brain/115.1.211

10.1146/annurev.ne.13.030190.000325

10.1002/(SICI)1097-0193(200006)10:2<49::AID-HBM10>3.0.CO;2-8

10.1162/089892901753165863

10.1038/85191

10.1016/S0896-6273(01)00423-8

1981, J Neurophysiol, 46, 744, 10.1152/jn.1981.46.4.744

1982, J Neurophysiol, 48, 1059, 10.1152/jn.1982.48.5.1059

10.1038/nn950

10.1002/1531-8257(200101)16:1<94::AID-MDS1020>3.0.CO;2-O

10.1093/brain/121.4.561

10.1006/nimg.1999.0514

10.1002/cne.902940213

10.1038/35004588

10.1002/mds.10019

10.1002/(SICI)1097-0193(1999)8:1<1::AID-HBM1>3.0.CO;2-E

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Thông tin xuất bản

Journal of Neuroscience

Tập 24 Số 10

2585-2591

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