The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice

Sebastian P. Fernandez1, Michael Nguyen2, Tin T Yow2, Cindy Chu2, Graham A.R. Johnston1, Jane R. Hanrahan2, Mary Chebib2
1Faculty of Medicine, Department of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia
2Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia

Tóm tắt

Từ khóa


Tài liệu tham khảo

Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55:481–504. doi: 10.1016/S0031-9422(00)00235-1

Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96:67–202. doi: 10.1016/S0163-7258(02)00298-X

Messina M, Ho S, Alekel DL (2004) Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data. Curr Opin Clin Nutr Metab Care 7:649–658. doi: 10.1097/00075197-200411000-00010

Grendys EC Jr, Blessing JA, Burger R et al (2005) A phase II evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: a gynaecologic oncology group study. Gynecol Oncol 98:249–253. doi: 10.1016/j.ygyno.2005.05.017

Katsenis K (2005) Micronized purified flavonoid fraction (MPFF): a review of its pharmacological effects, therapeutic efficacy and benefits in the management of chronic venous insufficiency. Curr Vasc Pharmacol 3:1–9. doi: 10.2174/1570161052773870

Fernandez SP, Wasowski C, Loscalzo LM et al (2006) Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol 539:168–176. doi: 10.1016/j.ejphar.2006.04.004

Viswanathan S, Sambantham PT, Reddy K et al (1984) Gossypin-induced analgesia in mice. Eur J Pharmacol 98:289–291. doi: 10.1016/0014-2999(84)90604-6

Meotti FC, Luiz AP, Pizzolatti MG et al (2006) Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the l-arginine-nitric oxide and protein kinase C pathways. J Pharmacol Exp Ther 316:789–796. doi: 10.1124/jpet.105.092825

Martínez-Vázquez M, Ramírez Apan TO, Lastra AL et al (1998) A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddelia cordata. Planta Med 64:134–137. doi: 10.1055/s-2006-957390

Loscalzo LM, Wasowski C, Paladini AC et al (2008) Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur J Pharmacol 580:306–313. doi: 10.1016/j.ejphar.2007.11.011

Kissin I, Brown PT, Bradley EL Jr (1990) Sedative and hypnotic midazolam-morphine interactions in rats. Anesth Analg 71:137–143

Zarrindast MR, Rostami P, Zarei M et al (2005) Intracerebroventricular effects of histaminergic agents on morphine-induced anxiolysis in the elevated plus-maze in rats. Basic Clin Pharmacol Toxicol 97:276–281. doi: 10.1111/j.1742-7843.2005.pto_116.x

Shin IC, Kim HC, Swanson J et al (2003) Anxiolyic effects of acute morphine can be modulate by nitric oxide systems. Pharmacology 68:183–189. doi: 10.1159/000070457

Agmo A, Galvan A, Heredia A et al (1995) Naloxone blocks the antianxiety but not the motor effects of benzodiazepines and pentobarbital: experimental studies and literature review. Psychopharmacology (Berl) 120:186–194. doi: 10.1007/BF02246192

Filliol D, Ghozland S, Chluba J et al (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25:195–200. doi: 10.1038/76061

Knabl J, Witschi R, Hösl K et al (2008) Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature 451:330–334. doi: 10.1038/nature06493

Pick CG (1997) Antinociceptive interaction between alprazolam and opioids. Brain Res Bull 42:239–243. doi: 10.1016/S0361-9230(96)00265-1

Fernandez SP, Mewett KN, Hanrahan JR et al (2008) Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology 55:900–907. doi: 10.1016/j.neuropharm.2008.06.069

File SE (2001) Factors controlling measures of anxiety and responses to novelty in the mouse. Behav Brain Res 125:151–157. doi: 10.1016/S0166-4328(01)00292-3

Bonetti EP, Pierri L, Cumin R et al (1982) Benzodiazepine antagonist RO 15–1788: neurological and behavioral effects. Psychopharmacology (Berl) 78:8–18. doi: 10.1007/BF00470579

Ashton CH (2003) Insomnia and anxiety. In: clinical pharmacy and therapeutics, 3rd edn. Churchill Livingstone, Sydney, pp 423–438

Ipser JC, Carey P, Dhansay Y, et al. (2006) Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders. Cochrane Database Syst Rev CD005473

Cryan JF, Holmes A (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 4:775–790. doi: 10.1038/nrd1825

Marder M, Paladini AC (2002) GABAA-receptor ligands of flavonoid structure. Curr Top Med Chem 2:853–867. doi: 10.2174/1568026023393462

Zitron E, Scholz E, Owen RW et al (2005) QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids. Circulation 111:835–838. doi: 10.1161/01.CIR.0000155617.54749.09

Kobayashi T, Ikeda K, Ichikawa T et al (1995) Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Biochem Biophys Res Commun 208:1166–1173. doi: 10.1006/bbrc.1995.1456

Guasti L, Cilia E, Crociani O et al (2005) Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J Comp Neurol 491:157–174. doi: 10.1002/cne.20721

Chu CP-Y (2006) Three Pharmacological studies on nicotinic acetylcholine receptors: β-amyloid peptides, flavonoids and α-conotoxins. Ph. D Thesis, University of Sydney, Sydney

Picciotto MR, Brunzell DH, Caldarone BJ (2002) Effect of nicotine and nicotinic receptors on anxiety and depression. NeuroReport 13:1097–1106. doi: 10.1097/00001756-200207020-00006

Meotti FC, Posser T, Missau FC et al (2007) Involvement of p38MAPK on the antinociceptive action of myricitrin in mice. Biochem Pharmacol 74:924–931. doi: 10.1016/j.bcp.2007.06.024

Walle T (2004) Absorption and metabolism of flavonoids. Free Radic Biol Med 36:829–837. doi: 10.1016/j.freeradbiomed.2004.01.002

Manach C, Williamson G, Morand C et al (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–242S

Bokkenheuser VD, Shackleton CH, Winter J (1987) Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans. Biochem J 248:953–956

Day AJ, DuPont MS, Ridley S et al (1998) Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett 436:71–75. doi: 10.1016/S0014-5793(98)01101-6

Day AJ, Canada FJ, Diaz JC et al (2000) Dietary flavonoid and isoflavones glycosides are hydrolysed by the lactase site of the lactase phlorizin hydrolase. FEBS Lett 468:166–170. doi: 10.1016/S0014-5793(00)01211-4

Tsai TH (2002) Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. J Agric Food Chem 50:6669–6674. doi: 10.1021/jf020603p

Peng HW, Cheng FC, Huang YT et al (1998) Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography. J Chromatogr A 714:369–374