The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates

Stephanie A. Studenski1, Kathy Peters2, Dawn E. Alley3, Peggy M. Cawthon2, Robert R. McLean4,5, Harri Niinikoski6, Luigi Ferrucci6, Jack M. Guralnik3, Maren S. Fragala7, Rose Anne Kenny8, Douglas P. Kiel4,5, Stephen B. Kritchevsky9, Michelle Shardell3, Thuy-Tien L. Dam10, Maria T. Vassileva11
1Department of Internal Medicine, School of Medicine, University of Pittsburgh, Pennsylvania.
2California Pacific Medical Center Research Institute, San Francisco
3Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore
4Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
5Institute for Aging Research, Hebrew Senior Life, Boston, Massachusetts
6Intramural Research Program, National Institute of Aging, National Institutes of Health, Bethesda, Maryland
7College of Education and Human Performance, University of Central Florida, Orlando.
8Center on Aging, University of Connecticut Health Center, Farmington
9Sticht Center on Aging & Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
10Department of Medicine, Columbia University College of Physicians and Surgeons, New York
11The Biomarkers Consortium, Foundation for the National Institutes of Health, Bethesda, Maryland.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Abellan van Kan, 2009, Epidemiology and consequences of sarcopenia, J Nutr Health Aging, 13, 708, 10.1007/s12603-009-0201-z

Visser, 2011, Consequences of sarcopenia, Clin Geriatr Med, 27, 387, 10.1016/j.cger.2011.03.006

Newman, 2003, Sarcopenia: alternative definitions and associations with lower extremity function, J Am Geriatr Soc, 51, 1602, 10.1046/j.1532-5415.2003.51534.x

Clark, 2008, Sarcopenia =/= dynapenia, J Gerontol A Biol Sci Med Sci, 63, 829, 10.1093/gerona/63.8.829

Schaap, 2012, Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons, Epidemiol Rev

Visser, 2005, Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons, J Gerontol A Biol Sci Med Sci, 60, 324, 10.1093/gerona/60.3.324

Newman, 2006, Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort, J Gerontol A Biol Sci Med Sci, 61, 72, 10.1093/gerona/61.1.72

Visser, 2002, Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study, J Am Geriatr Soc, 50, 897, 10.1046/j.1532-5415.2002.50217.x

Alley, 2014, Grip strength cutpoints for the identification of clinically relevant weakness, J Gerontol A Biol Sci Med Sci, 5, 559, 10.1093/gerona/glu011

Cawthon, 2014, Cut-points for low appendicular lean mass that identify older adults with clinically significant weakness, J Gerontol A Biol Sci Med Sci, 5, 567, 10.1093/gerona/glu023

McLean, 2014, Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project, J Gerontol A Biol Sci Med Sci, 5, 576, 10.1093/gerona/glu012

Dam, 2014, An evidence-based comparison of candidate criteria for the presence of sarcopenia, J Gerontol A Biol Sci Med Sci, 5, 584, 10.1093/gerona/glu013

Studenski, 2011, Gait speed and survival in older adults, JAMA, 305, 50, 10.1001/jama.2010.1923

Abellan van Kan, 2009, Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force, J Nutr Health Aging, 13, 881, 10.1007/s12603-009-0246-z

Cruz-Jentoft, 2010, Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People, Age Ageing, 39, 412, 10.1093/ageing/afq034

Harris, 2007, Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics, Am J Epidemiol, 165, 1076, 10.1093/aje/kwk115

Tucker, 2010, The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities, BMC Public Health, 10, 107, 10.1186/1471-2458-10-107

Hutchins-Wiese, 2013, The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women, J Nutr Health Aging, 17, 76, 10.1007/s12603-012-0415-3

Judge, 2005, Home-based resistance training improves femoral bone mineral density in women on hormone therapy, Osteoporos Int, 16, 1096, 10.1007/s00198-004-1816-x

Kenny, 2003, Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men, J Am Geriatr Soc, 51, 1762, 10.1046/j.1532-5415.2003.51561.x

Kenny, 2010, Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women, J Am Geriatr Soc, 58, 1707, 10.1111/j.1532-5415.2010.03019.x

Kenny, 2001, Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, J Gerontol A Biol Sci Med Sci, 56, M266, 10.1093/gerona/56.5.M266

Prestwood, 2003, Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial, JAMA, 290, 1042, 10.1001/jama.290.8.1042

Dawber, 1951, Epidemiological approaches to heart disease: the Framingham Study, Am J Public Health Nations Health, 41, 279, 10.2105/AJPH.41.3.279

Kannel, 1979, An investigation of coronary heart disease in families. The Framingham offspring study, Am J Epidemiol, 110, 281, 10.1093/oxfordjournals.aje.a112813

Newman, 2003, Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study, J Am Geriatr Soc, 51, 323, 10.1046/j.1532-5415.2003.51105.x

Ferrucci, 2000, Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study, J Am Geriatr Soc, 48, 1618, 10.1111/j.1532-5415.2000.tb03873.x

Blank, 2005, Overview of recruitment for the osteoporotic fractures in men study (MrOS), Contemp Clin Trials, 26, 557, 10.1016/j.cct.2005.05.005

Orwoll, 2005, Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study–a large observational study of the determinants of fracture in older men, Contemp Clin Trials, 26, 569, 10.1016/j.cct.2005.05.006

Castillo, 2003, Sarcopenia in elderly men and women: the Rancho Bernardo study, Am J Prev Med, 25, 226, 10.1016/S0749-3797(03)00197-1

Cummings, 1995, Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group, N Engl J Med, 332, 767, 10.1056/NEJM199503233321202

Cauley, 2005, Bone mineral density and the risk of incident nonspinal fractures in black and white women, JAMA, 293, 2102, 10.1001/jama.293.17.2102

Guralnik, 2000, Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery, J Gerontol A Biol Sci Med Sci, 55, M221, 10.1093/gerona/55.4.M221

Härkönen, 1993, Grip strength and hand position of the dynamometer in 204 Finnish adults, J Hand Surg Br, 18, 129, 10.1016/0266-7681(93)90212-X

Salamone, 2000, Measurement of fat mass using DEXA: a validation study in elderly adults, J Appl Physiol (1985), 89, 345, 10.1152/jappl.2000.89.1.345

Visser, 1999, Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study–Dual-Energy X-ray Absorptiometry and Body Composition Working Group, J Appl Physiol (1985), 87, 1513, 10.1152/jappl.1999.87.4.1513

Baumgartner, 1998, Epidemiology of sarcopenia among the elderly in New Mexico, Am J Epidemiol, 147, 755, 10.1093/oxfordjournals.aje.a009520

Chobanian, 2003, The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report, JAMA, 289, 2560, 10.1001/jama.289.19.2560

Genuth, 2003, Follow-up report on the diagnosis of diabetes mellitus, Diabetes Care, 26, 3160, 10.2337/diacare.26.11.3160

Grundy, 2004, Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines, Circulation, 110, 227, 10.1161/01.CIR.0000133317.49796.0E