The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories

European Respiratory Journal - Tập 38 Số 3 - Trang 635-642 - 2011
Jan Hedner1, Ludger Grote2, Maria R. Bonsignore3, Walter T. McNicholas4, Peretz Lavie5, Gianfranco Parati6, Paweł Śliwiński7, Ferrán Barbé8, W. De Backer9, P. Escourrou10, Ingo Fietze11, John A. Kvamme12, Carolina Lombardi6, Oreste Marrone3, Juan F. Masa13, Josep M. Montserrat14, Thomas Penzel11, Martin Pretl15, Renata L. Riha16, Daniel Rodenstein17, Tarja Saaresranta18, Richard Schulz19, Ružena Tkáčová20, Giedrius Varoneckas21, A. Vitols22, H. Vrints9, J Zieliński23
1ESADA office, Gothenburg University, Centre for Sleep and Vigilance Disorders, Gothenburg, Sweden.
2Sahlgrens Univ Hosp, Sleep Lab
3CNR Inst Biomed & Mol Immunol IBIM
4St Vincents Univ Hosp, University College Dublin, Dept Resp Med
5Technion Israel Inst Technol, Technion Israel Institute of Technology, Rambam Med Ctr, Sleep Lab
6Fondazione Istituto Auxologico Italiano
7Inst TB & Lung Dis, Dept Diag & Treatment Resp Failure
8Hosp Santa Maria, Hospital Santa Maria, Universidade de Lisboa, Serv Neurol
9Univ Antwerp Hosp, University of Antwerp, Dept Pulm Med
10Hosp Antoine Beclere, Serv Explorat Fonct Multidisciplinaires
11Schlafmedizinisches Zentrum
12Forde Cent Hosp, ENT Dept, Sleep Lab
13Hosp San Pedro de Alcantara
14Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. [email protected]
15Charles Univ Prague, Charles University Prague, Fac Med 1, Dept Neurol, Sleep Disorders Ctr
16Royal Infirm Edinburgh NHS Trust, Royal Infirmary of Edinburgh, University of Edinburgh, Dept Sleep Med
17Univ Clin Schleswig Holstein
18Turku Univ Cent Hosp Paimio, Hosp Dept Pulm Dis
19Univ Giessen, Justus Liebig University Giessen, Lung Ctr, Sleep Disorders Ctr
20Safarik Univ, University of Pavol Jozef Safarik Kosice, Fac Med, Dept Resp Med
21Institute of Psychophysiology and Rehabilitation
22Univ Latvia, University of Latvia, Inst Cardiol
23Warsaw Med Univ, Medical University Warsaw, Dept Pneumonol

Tóm tắt

The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by a COST action B26 programme. This ongoing project aims to describe differences in standard clinical care of patients with obstructive sleep apnoea (OSA) and to establish a resource for genetic research in this disorder.Patients with suspected OSA are consecutively included and followed up according to local clinical standards. Anthropometrics, medical history, medication, daytime symptoms and sleep data (polysomnography or cardiorespiratory polygraphy) are recorded in a structured web-based report form.5,103 patients (1,426 females, mean±sdage 51.8±12.6 yrs, 79.4% with apnoea/hypopnoea index (AHI) ≥5 events·h−1) were included from March 15, 2007 to August 1, 2009. Morbid obesity (body mass index ≥35 kg·m−2) was present in 21.1% of males and 28.6% of females. Cardiovascular, metabolic and pulmonary comorbidities were frequent (49.1%, 32.9% and 14.2%, respectively). Patients investigated with a polygraphic method had a lower AHI than those undergoing polysomnography (23.2±23.5versus29.1±26.3 events·h−1, p<0.0001).The ESADA is a rapidly growing multicentre patient cohort that enables unique outcome research opportunities and genotyping. The first cross-sectional analysis reveals a high prevalence of cardiovascular and metabolic morbidity in patients investigated for OSA.

Từ khóa


Tài liệu tham khảo

10.1056/NEJM199304293281704

10.1183/09031936.00180108

Nowak, 2006, Daytime impairment and neurodegeneration in OSAS, Sleep, 29, 1521, 10.1093/sleep/29.12.1521

10.1111/j.1365-2869.2008.00669.x

10.1183/09031936.00027406

10.1016/j.pcad.2009.01.002

10.1253/circj.CJ-09-0364

WHO Collaborating Centre for Drug Statistics Methodology, Guidelines for ATC Classification and DDD Assignment. 6th Edn. Oslo, World Health Organization, 2003.

Ferber, 1994, Portable recording in the assessment of obstructive sleep apnea. ASDA standards of practice, Sleep, 17, 378, 10.1093/sleep/17.4.378

Iber C Ancoli-Israel S Chesson A . The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 1st Edn. Westchester, American Academy of Sleep Medicine, 2007.

Johns, 1991, A new method for measuring daytime sleepiness: the Epworth sleepiness scale, Sleep, 14, 540, 10.1093/sleep/14.6.540

Silva, 2007, Relationship between reported and measured sleep times: the sleep heart health study (SHHS), J Clin Sleep Med, 3, 622, 10.5664/jcsm.26974

10.1164/rccm.2109080

Kapur, 2005, Sleepiness in patients with moderate to severe sleep-disordered breathing, Sleep, 28, 472, 10.1093/sleep/28.4.472

10.1164/ajrccm.162.1.9905035

10.1136/bmj.320.7233.479

10.1034/j.1399-3003.2000.16a23.x

Nieto, 2000, Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study, Sleep Heart Health Study. JAMA, 283, 1829

Thông tin
Thông tin xuất bản

European Respiratory Journal

Tập 38 Số 3

635-642

Thông tin tác giả