The Estrogen Receptor Is Not Essential for All Estrogen Neuroprotection: New Evidence from a New Analog

Neurobiology of Disease - Tập 9 - Trang 282-293 - 2002
Shuli Xia1,2, Zu Yun Cai3, Liu Lin Thio1,2,4, Jeong Sook Kim-Han1,2, Laura L. Dugan1,2, Douglas F. Covey3, Steven M. Rothman1,2,4
1Department of Neurology, Washington University School of Medicine, St. Louis, Mssouri, 63110
2Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Mssouri, 63110
3Department of Molecular Biology & Pharmacology, Washington University School of Medicine, St. Louis, Mssouri, 63110
4Department of Neurology, St. Louis Children's Hospital, St. Louis, Missouri, 63110

Tài liệu tham khảo

Bae, 2000, Anti-oxidative neuroprotection by estrogens in mouse cortical cultures, J. Korean Med. Sci., 15, 327, 10.3346/jkms.2000.15.3.327 Behl, 1999, The female sex hormone oestrogen as a neuroprotectant, Trends Pharmacol. Sci., 20, 441, 10.1016/S0165-6147(99)01392-9 Behl, 1997, Neuroprotection against oxidative stress by estrogens: Structure–activity relationship, Mol. Pharmacol., 51, 535, 10.1124/mol.51.4.535 Behl, 1995, 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro, Biochem. Biophys. Res. Commun., 216, 473, 10.1006/bbrc.1995.2647 Benson, 1999, Hormone replacement therapy and Alzheimer's disease: An update on the issues, Health Care Women Int., 20, 619, 10.1080/073993399245502 Beyer, 1999, Estrogen and the developing mammalian brain, Anat. Embryol. (Berlin), 199, 379, 10.1007/s004290050236 Birge, 1997, The role of estrogen in the treatment of Alzheimer's disease, Neurology, 48, S36, 10.1212/WNL.48.5_Suppl_7.36S Blanchet, 1999, Short-term effects of high-dose 17beta-estradiol in postmenopausal PD patients: A crossover study, Neurology, 53, 91, 10.1212/WNL.53.1.91 Bondy, 1993, The relationship between excitotoxicity and oxidative stress in the central nervous system, Free Radi. Biol. Med., 14, 633, 10.1016/0891-5849(93)90144-J Brinton, 1997, 17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture, Neurochem. Res., 22, 1339, 10.1023/A:1022015005508 Dugan, 1995, Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate, J. Neurosci., 15, 6377, 10.1523/JNEUROSCI.15-10-06377.1995 Fan, 2001, ZYC-13, the enantiomer of 1,3,5(10)-estratriene 3-OL, exerts neuroprotective effects in vitro and in vivo, Soc. Neurosci. Abstracts, 27, Garcia-Segura, 2001, Neuroprotection by estradiol, Prog. Neurobiol., 63, 29, 10.1016/S0301-0082(00)00025-3 Gollapudi, 1999, Stable transfection of PC12 cells with estrogen receptor (ERalpha): Protective effects of estrogen on cell survival after serum deprivation, J. Neurosci. Res., 56, 99, 10.1002/(SICI)1097-4547(19990401)56:1<99::AID-JNR13>3.0.CO;2-G Goodman, 1996, Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons, J. Neurochem., 66, 1836, 10.1046/j.1471-4159.1996.66051836.x Green, 1997, 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells, J. Neurosci., 17, 511, 10.1523/JNEUROSCI.17-02-00511.1997 Green, 1997, Phenolic A ring requirement for the neuroprotective effects of steroids, J. Steroid Biochem. Mol. Biol., 63, 229, 10.1016/S0960-0760(97)00124-6 Green, 2000, Neuroprotective effects of estrogens: Potential mechanisms of action, Int. J. Dev. Neurosci., 18, 347, 10.1016/S0736-5748(00)00017-4 Green, 2001, The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia, Endocrinology, 142, 400, 10.1210/en.142.1.400 Gridley, 1998, A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25-35-induced toxicity in vitro, Mol. Pharmacol., 54, 874, 10.1124/mol.54.5.874 Grynkiewicz, 1985, A new generation of Ca2+ indicators with greatly improved fluorescence properties, J. Biol. Chem., 260, 3440, 10.1016/S0021-9258(19)83641-4 Gwag, 1997, Slowly triggered excitotoxicity occurs by necrosis in cortical cultures, Neuroscience, 77, 393, 10.1016/S0306-4522(96)00473-3 Harms, 2001, Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration, J. Neurosci., 21, 2600, 10.1523/JNEUROSCI.21-08-02600.2001 Henderson, 1997, Estrogen, cognition, and a woman's risk of Alzheimer's disease, Am. J. Med., 103, 11S, 10.1016/S0002-9343(97)00261-1 Hurn, 2000, Estrogen as a neuroprotectant in stroke, J. Cereb. Blood Flow Metab., 20, 631, 10.1097/00004647-200004000-00001 Hwang, 1999, N-Methyl-d-aspartate receptor blockade induces neuronal apoptosis in cortical culture, Exp. Neurol., 159, 124, 10.1006/exnr.1999.7126 Ikonomidou, 1999, Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain, Science, 283, 70, 10.1126/science.283.5398.70 Joza, 2001, Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death, Nature, 410, 549, 10.1038/35069004 Keller, 1997, 17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron, J. Neurosci. Res., 50, 522, 10.1002/(SICI)1097-4547(19971115)50:4<522::AID-JNR3>3.0.CO;2-G Lunn, 1968, The adamantyl carbonium ion as a dehydrogenating agent, its reactions with estrone, Tetrahedron, 24, 6773, 10.1016/S0040-4020(01)96851-6 Mayeux, 1995, The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988–1993, Am. J. Epidemiol., 142, 820, 10.1093/oxfordjournals.aje.a117721 McDonald, 1997, Susceptibility to apoptosis is enhanced in immature cortical neurons, Brain Res., 759, 228, 10.1016/S0006-8993(97)00248-5 Miller, 1996, In vitro antioxidant effects of estrogens with a hindered 3-OH function on the copper-induced oxidation of low density lipoprotein, Steroids, 61, 305, 10.1016/0039-128X(95)00234-H Mooradian, 1993, Antioxidant properties of steroids, J. Steroid Biochem. Mol. Biol., 45, 509, 10.1016/0960-0760(93)90166-T Moosmann, 1999, The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties, Proc. Natl. Acad. Sci. USA, 96, 8867, 10.1073/pnas.96.16.8867 Pike, 1999, Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease, J. Neurochem., 72, 1552, 10.1046/j.1471-4159.1999.721552.x Purdie, 1999, Hormone replacement therapy and risk of epithelial ovarian cancer, Br. J. Cancer, 81, 559, 10.1038/sj.bjc.6690731 Regan, 1997, Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures, Brain Res., 764, 133, 10.1016/S0006-8993(97)00437-X Reynolds, 1995, Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation, J. Neurosci., 15, 3318, 10.1523/JNEUROSCI.15-05-03318.1995 Rifici, 1992, The inhibition of low-density lipoprotein oxidation by 17-beta estradiol, Metabolism, 41, 1110, 10.1016/0026-0495(92)90295-L Rose, 1992, Cytotoxicity in murine neocortical cell culture, 46 Sawada, 1998, Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death, J. Neurosci. Res., 54, 707, 10.1002/(SICI)1097-4547(19981201)54:5<707::AID-JNR16>3.0.CO;2-T Shughrue, 2000, Estrogen is more than just a “sex hormone”: Novel sites for estrogen action in the hippocampus and cerebral cortex, Front. Neuroendocrinol., 21, 95, 10.1006/frne.1999.0190 Singer, 1999, The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons, J. Neurosci., 19, 2455, 10.1523/JNEUROSCI.19-07-02455.1999 Singer, 1998, Modulation of Bcl-2 expression: A potential component of estrogen protection in NT2 neurons, Neuroreport, 9, 2565, 10.1097/00001756-199808030-00025 Singer, 1996, Estrogen protects primary cortical neurons from glutamate toxicity, Neurosci. Lett., 212, 13, 10.1016/0304-3940(96)12760-9 Singh, 1999, Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways, J. Neurosci., 19, 1179, 10.1523/JNEUROSCI.19-04-01179.1999 Tang, 1996, Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease, Lancet, 348, 429, 10.1016/S0140-6736(96)03356-9 Terro, 2000, N-methyl-d-aspartate receptor blockade enhances neuronal apoptosis induced by serum deprivation, Neurosci. Lett., 278, 149, 10.1016/S0304-3940(99)00911-8 Vegeto, 2001, Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia, J. Neurosci., 21, 1809, 10.1523/JNEUROSCI.21-06-01809.2001 Watters, 1998, Transcriptional effects of estrogen on neuronal neurotensin gene expression involve cAMP/protein kinase A-dependent signaling mechanisms, J. Neurosci., 18, 6672, 10.1523/JNEUROSCI.18-17-06672.1998 Weaver, 1997, 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors, Brain Res., 761, 338, 10.1016/S0006-8993(97)00449-6 Yamada, 1996, Allosteric interactions between cyclothiazide and AMPA/kainate receptor antagonists, Br. J. Pharmacol., 117, 1663, 10.1111/j.1476-5381.1996.tb15337.x