The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace

Siegel, 2007, 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings, Am J Infect Control, 35, S65, 10.1016/j.ajic.2007.10.007

Siegel, 2007, Management of multidrug-resistant organisms in health care settings, 2006, Am J Infect Control, 35, S165, 10.1016/j.ajic.2007.10.006

Prabaker, 2011, Trends in antimicrobial resistance in intensive care units in the United States, Curr Opin Crit Care, 17, 472, 10.1097/MCC.0b013e32834a4b03

Bush, Top 10 Beta-lactamase Papers for 2015

Jacoby, 2005, The new β-lactamases, N Engl J Med, 352, 380, 10.1056/NEJMra041359

Bush, 2011, Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria, Annu Rev Microbiol, 65, 455, 10.1146/annurev-micro-090110-102911

Thomson, 2005, The threat of antibiotic resistance in Gram-negative pathogenic bacteria: β-lactams in peril!, Curr Opin Microbiol, 8, 518, 10.1016/j.mib.2005.08.014

Patel, 2013, “Stormy waters ahead”: global emergence of carbapenemases, Front Microbiol, 4, 1, 10.3389/fmicb.2013.00048

Bush, 2010, Updated functional classification of beta-lactamases, Antimicrob Agents Chemother, 54, 969, 10.1128/AAC.01009-09

Ambler, 1980, The structure of beta-lactamases, Philos Trans R Soc Lond B Biol Sci, 289, 321, 10.1098/rstb.1980.0049

Carattoli, 2009, Resistance plasmid families in Enterobacteriaceae, Antimicrob Agents Chemother, 53, 2227, 10.1128/AAC.01707-08

Poirel, 2012, OXA-48-like carbapenemases: the phantom menace, J Antimicrob Chemother, 67, 1597, 10.1093/jac/dks121

Queenan, 2007, Carbapenemases: the versatile β-lactamases, Clin Microbiol Rev, 20, 440, 10.1128/CMR.00001-07

Logan, 2012, Carbapenem-resistant Enterobacteriaceae: an emerging problem in children, Clin Infect Dis, 55, 852, 10.1093/cid/cis543

Pitout, Worldwide spread of carbapenemases: update 2015 and future prospects

Chen, 2014, Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding, Trends Microbiol, 22, 686, 10.1016/j.tim.2014.09.003

Paterson, 2005, Extended-spectrum β-lactamases: a clinical update, Clin Microbiol Rev, 18, 657, 10.1128/CMR.18.4.657-686.2005

Jacoby, 2009, AmpC beta-lactamases, Clin Microbiol Rev, 22, 161, 10.1128/CMR.00036-08

Nordmann, 2009, The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria, Lancet Infect Dis, 9, 228, 10.1016/S1473-3099(09)70054-4

Kitchel, 2009, Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258, Antimicrob Agents Chemother, 53, 3365, 10.1128/AAC.00126-09

Cuzon, 2011, Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization, Antimicrob Agents Chemother, 55, 5370, 10.1128/AAC.05202-11

Chen, 2014, Epidemic Klebsiella pneumoniae ST258 Is a Hybrid Strain, mBio, 5, 10.1128/mBio.01355-14

Kitchel, 2010, Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae, Antimicrob Agents Chemother, 54, 4201, 10.1128/AAC.00008-10

Poirel, 2010, Diversity, epidemiology, and genetics of class D β-lactamases, Antimicrob Agents Chemother, 54, 24, 10.1128/AAC.01512-08

Carrer, 2010, Spread of OXA-48-encoding plasmid in Turkey and beyond, Antimicrob Agents Chemother, 54, 1369, 10.1128/AAC.01312-09

Poirel, 2012, Genetic features of the widespread plasmid coding for the carbapenemase OXA-48, Antimicrob Agents Chemother, 56, 559, 10.1128/AAC.05289-11

Walsh, 2010, Emerging carbapenemases: a global perspective, Int J Antimicrob Agents, 36, S8, 10.1016/S0924-8579(10)70004-2

Mojica, 2016, B1-metallo-beta-lactamases: where do we stand?, Curr Drug Targets, 17, 1029, 10.2174/1389450116666151001105622

Dortet, 2012, Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii, Antimicrob Agents Chemother, 56, 1693, 10.1128/AAC.05583-11

Dortet, 2014, Worldwide dissemination of the NDM-type carbapenemases in Gram-negative bacteria, Biomed Res Int, 2014, 249856, 10.1155/2014/249856

Nordmann, 2011, Global spread of carbapenemase-producing Enterobacteriaceae, Emerg Infect Dis, 17, 1791, 10.3201/eid1710.110655

Glasner, 2013, Carbapenemase-producing Enterobacteriaceae in Europe: a survey among national experts from 39 countries, February 2013, Euro Surveill, 18, 20525, 10.2807/1560-7917.ES2013.18.28.20525

Munoz-Price, 2013, Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases, Lancet Infect Dis, 13, 785, 10.1016/S1473-3099(13)70190-7

European Centre for Disease Prevention and Control (EARS-Net)

Giakkoupi, 2011, An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009–10), J Antimicrob Chemother, 66, 1510, 10.1093/jac/dkr166

Adler, 2015, Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-acute-care hospitals in Israel, 2008–13, J Antimicrob Chemother, 70, 89, 10.1093/jac/dku333

Castanheira, 2012, Expansion of clonal complex 258 KPC-2-producing Klebsiella pneumoniae in Latin American hospitals: report of the SENTRY Antimicrobial Surveillance Program, Antimicrob Agents Chemother, 56, 1668, 10.1128/AAC.05942-11

Cantón, 2012, Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe, Clin Microbiol Infect, 18, 413, 10.1111/j.1469-0691.2012.03821.x

Badal, Geographic distribution of carbapenemases found in Enterobacteriaceae—SMART 2012 [abstract C-799]

Ito, 1995, Plasmid-mediated dissemination of the metallo-beta-lactamase gene blaIMP among clinically isolated strains of Serratia marcescens, Antimicrob Agents Chemother, 39, 824, 10.1128/AAC.39.4.824

Yan, 2002, Metallo-beta-lactamase-producing Enterobacteriaceae isolates in a university hospital in Taiwan: prevalence of IMP-8 in Enterobacter cloacae and first identification of VIM-2 in Citrobacter freundii, J Antimicrob Chemother, 50, 503, 10.1093/jac/dkf170

Lauretti, 1999, Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate, Antimicrob Agents Chemother, 43, 1584, 10.1128/AAC.43.7.1584

Poirel, 2000, Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France, Antimicrob Agents Chemother, 44, 891, 10.1128/AAC.44.4.891-897.2000

Walsh, 2005, Metallo-ß-Lactamases: the Quiet before the Storm?, Clin Microbiol Rev, 18, 306, 10.1128/CMR.18.2.306-325.2005

Vatopoulos, 2008, High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece--a review of the current evidence, Euro Surveill, 13, 8023, 10.2807/ese.13.04.08023-en

Yong, 2009, Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India, Antimicrob Agents Chemother, 53, 5046, 10.1128/AAC.00774-09

Kumarasamy, 2010, Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study, Lancet Infect Dis, 10, 597, 10.1016/S1473-3099(10)70143-2

Bharadwaj, 2012, Prevalence of New Delhi metallo-beta-lactamase (NDM-1)-positive bacteria in a tertiary care centre in Pune, India, Int J Antimicrob Agents, 39, 265, 10.1016/j.ijantimicag.2011.09.027

Deshpande, 2010, New Delhi metallo 1: have carbapenems met their doom?, Clin Infect Dis, 51, 1222, 10.1086/656921

Perry, 2011, Prevalence of faecal carriage of Enterobacteriaceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic media, J Antimicrob Chemother, 66, 2288, 10.1093/jac/dkr299

Castanheira, 2011, Early dissemination of NDM-1- and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006–2007, Antimicrob Agents Chemother, 55, 1274, 10.1128/AAC.01497-10

Lascols, 2011, Increasing prevalence and dissemination of NDM-1 metallo-β-lactamase in India: data from the SMART study (2009), J Antimicrob Chemother, 66, 1992, 10.1093/jac/dkr240

Walsh, 2011, Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study, Lancet Infect Dis, 11, 355, 10.1016/S1473-3099(11)70059-7

Poirel, 2004, Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae, Antimicrob Agents Chemother, 48, 15, 10.1128/AAC.48.1.15-22.2004

Souli, 2010, An outbreak of infection due to ß-Lactamase Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae in a Greek university hospital: molecular characterization, epidemiology, and outcomes, Clin Infect Dis, 50, 364, 10.1086/649865

Giakoupi, 2009, KPC-2-producing Klebsiella pneumoniae infections in Greek hospitals are mainly due to a hyperepidemic clone, Euro Surveill, 14, 19218

Leavitt, 2007, Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital, Antimicrob Agents Chemother, 51, 3026, 10.1128/AAC.00299-07

Schwaber, 2011, Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention, Clin Infect Dis, 52, 848, 10.1093/cid/cir025

Mojica, 2012, Molecular correlates of the spread of KPC-producing Enterobacteriaceae in Colombia, Int J Antimicrob Agents, 40, 277, 10.1016/j.ijantimicag.2012.05.006

Villegas, 2006, First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America, Antimicrob Agents Chemother, 50, 2880, 10.1128/AAC.00186-06

Maya, 2013, Current status of carbapenemases in Latin America, Expert Rev Anti Infect Ther, 11, 657, 10.1586/14787210.2013.811924

Villegas, 2007, First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase, Antimicrob Agents Chemother, 51, 1553, 10.1128/AAC.01405-06

Andrade, 2011, Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil, Antimicrob Agents Chemother, 55, 3579, 10.1128/AAC.01783-10

Perenguez, Molecular characterization of carbapenemases among Enterobacteriaceae in Latin America (LatAm) [abstract C-801]

Pereira, 2013, Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340), J Antimicrob Chemother, 68, 312, 10.1093/jac/dks396

Yigit, 2001, Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae, Antimicrob Agents Chemother, 45, 1151, 10.1128/AAC.45.4.1151-1161.2001

Bradford, 2004, Emergence of carbapenem-resistant Klebsiella species possessing the class a carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City, Clin Infect Dis, 39, 55, 10.1086/421495

Rhomberg, 2007, Activity of meropenem as serine carbapenemases evolve in US medical centers: monitoring report from the MYSTIC program (2006), Diagn Microbiol Infect Dis, 59, 425, 10.1016/j.diagmicrobio.2007.05.009

Deshpande, 2006, Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States Medical Centers: report from the MYSTIC Program (1999–2005), Diagn Microbiol Infect Dis, 56, 367, 10.1016/j.diagmicrobio.2006.07.004

Kaiser, 2013, Trends in Klebsiella pneumoniae carbapenemase-positive K. pneumoniae in US hospitals: report from the 2007–2009 SENTRY Antimicrobial Surveillance Program, Diagn Microbiol Infect Dis, 76, 356, 10.1016/j.diagmicrobio.2013.03.032

Castanheira, 2013, Prevalence of β-lactamase-encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 U.S. hospitals: report from the SENTRY Antimicrobial Surveillance Program (2010), Antimicrob Agents Chemother, 3012

Guh, 2015, Epidemiology of carbapenem-resistant Enterobacteriaceae in 7 US communities, 2012–2013, JAMA, 314, 1479, 10.1001/jama.2015.12480

Centers for Disease Control and Prevention. Tracking CRE

Logan, 2015, Carbapenem-resistant Enterobacteriaceae in children, United States, 1999–2012, Emerg Infect Dis, 21, 2014, 10.3201/eid2111.150548

Logan, 2016, Metallo-β-lactamase (MBL)-producing Enterobacteriaceae in United States children, Open Forum Infect Dis, 10.1093/ofid/ofw090

Suwantarat, 2016, The prevalence and molecular epidemiology of multidrug-resistant Enterobacteriaceae colonization in a pediatric intensive care unit, Infect Control Hosp Epidemiol, 37, 535, 10.1017/ice.2016.16

Stillwell, 2015, Outbreak of KPC-3 Producing Carbapenem-Resistant Klebsiella pneumoniae in a US Pediatric Hospital, J Pediatric Infect Dis Soc, 4, 330, 10.1093/jpids/piu080

Pannaraj, 2015, Pediatric carbapenem-resistant Enterobacteriaceae in Los Angeles, California, a high-prevalence region in the United States, Pediatric Infect Dis J, 34, 11, 10.1097/INF.0000000000000471

Viau, 2012, “Silent” dissemination of Klebsiella pneumoniae isolates bearing K. pneumoniae carbapenemase in a long-term care facility for children and young adults in Northeast Ohio, Clin Infect Dis, 54, 1314, 10.1093/cid/cis036

Tumbarello, 2012, Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy, Clin Infect Dis, 55, 943, 10.1093/cid/cis588

Kallen, 2013, Vital signs: carbapenem-resistant Enterobacteriaceae, Morb Mortal Wkly Rep, 62, 165

Temkin, 2014, Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management, Ann N Y Acad Sci, 1323, 22, 10.1111/nyas.12537

Falagas, 2007, Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case–control study, J Antimicrob Chemother, 60, 1124, 10.1093/jac/dkm356

Gupta, 2011, Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention, Clin Infect Dis, 53, 60, 10.1093/cid/cir202

Chiotos, 2016, Carbapenem-resistant Enterobacteriaceae infections in children, Curr Infect Dis Rep, 18, 1, 10.1007/s11908-015-0510-9

Scaggs, Klebsiella pneumoniae carbapenemase (KPC) producing Enterobacteriaceae infections in children: A two-center study, 10.1093/ofid/ofv133.1290

Scaggs, A multi-centered study of factors associated with Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae infections in children

Prabaker, 2012, Transfer from high-acuity long-term care facilities is associated with carriage of Klebsiella pneumoniae carbapenemase–producing Enterobacteriaceae: a multihospital study, Infect Control Hosp Epidemiol, 33, 1193, 10.1086/668435

Lin, 2013, The importance of long-term acute care hospitals in the regional epidemiology of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae, Clin Infect Dis, 57, 1246, 10.1093/cid/cit500

Mills, 2016, The epidemiology of carbapenem-resistant Klebsiella pneumoniae colonization and infection among long-term acute care hospital residents, Infect Control Hosp Epidemiol, 37, 55, 10.1017/ice.2015.254

Munoz-Price, 2010, Successful control of an outbreak of Klebsiella pneumoniae carbapenemase—producing K. pneumoniae at a long-term acute care hospital, Infect Control Hosp Epidemiol, 31, 341, 10.1086/651097

CDC. 2012 CRE toolkit—guidance for control of carbapenem-resistant Enterobacteriaceae (CRE)

Trick, 2015, Electronic public health registry of extensively drug-resistant organisms, Illinois, USA, Emerg Infect Dis, 21, 1725, 10.3201/eid2110.150538

Liu, 2016, Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study, Lancet Infect Dis, 16, 161, 10.1016/S1473-3099(15)00424-7

Poirel, 2016, Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli, Lancet Infect Dis, 16, 281, 10.1016/S1473-3099(16)00006-2

Paterson, 2016, Colistin resistance: a major breach in our last line of defence, Lancet Infect Dis, 16, 132, 10.1016/S1473-3099(15)00463-6

Skov, 2016, Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds, Euro Surveill, 21, 30155, 10.2807/1560-7917.ES.2016.21.9.30155