The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes

Artavanis-Tsakonas, 1995, Notch signaling, Science, 268, 225, 10.1126/science.7716513 Bailey, 1995, Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity, Genes Dev., 9, 2609, 10.1101/gad.9.21.2609 Bier, 1992, deadpan, an essential pan-neural gene in Drosophila, encodes a helix- loop-helix protein similar to the hairy gene product, Genes Dev., 6, 2137, 10.1101/gad.6.11.2137 Brand, 1993, Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, 118, 401, 10.1242/dev.118.2.401 Campos-Ortega, J.A., 1993. The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. Campos-Ortega, J.A., Hartenstein, V., 1985. The Embryonic Development of Drosophila melanogaster. Springer, New York. Cavener, 1987, Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates, Nucl. Acids Res., 15, 1353, 10.1093/nar/15.4.1353 Chou, 1992, Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila, Genetics, 131, 643, 10.1093/genetics/131.3.643 Corbin, 1991, A role for the Drosophila neurogenic genes in mesoderm differentiation, Cell, 67, 311, 10.1016/0092-8674(91)90183-Y de Celis, 1996, Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development, Development, 122, 2719, 10.1242/dev.122.9.2719 Delidakis, 1992, The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins, Proc. Natl. Acad. Sci. USA, 89, 8731, 10.1073/pnas.89.18.8731 Devereux, 1984, A comprehensive set of sequence analysis programs for the VAX, Nucl. Acids Res., 12, 387, 10.1093/nar/12.1Part1.387 Diaz-Benjumea, 1995, Serrate signals through Notch to establish a wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing, Development, 121, 4215, 10.1242/dev.121.12.4215 Eastman, 1997, Synergy between Suppressor of Hairless and Notch in regulation of Enhancer of split mγ and mδ expression, Mol. Cell. Biol., 17, 5620, 10.1128/MCB.17.9.5620 Gorman, 1995, Genetic analysis of embryonic cis-acting regulatory elements of the Drosophila homeotic gene Sex combs reduced, Genetics, 140, 557, 10.1093/genetics/140.2.557 Jennings, 1995, Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins, Development, 121, 3745, 10.1242/dev.121.11.3745 Jennings, 1994, The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo, Development, 120, 3537, 10.1242/dev.120.12.3537 Klämbt, 1989, Closely related transcripts encoded by the neurogenic gene complex Enhancer of split of Drosophila melanogaster, EMBO, J 8, 203, 10.1002/j.1460-2075.1989.tb03365.x Knust, 1992, Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins, Genetics, 132, 505, 10.1093/genetics/132.2.505 Kopan, 1996, The Notch pathway: democracy and aristocracy in the selection of cell fate, Curr. Opin. Neurobiol., 6, 594, 10.1016/S0959-4388(96)80090-0 Kumazaki, 1990, Disulfide bridge structure of ascidian trypsin inhibitor I: similarity to Kazal-type inhibitors, J. Biochem. (Tokyo), 107, 414, 10.1093/oxfordjournals.jbchem.a123059 Lai, 1998, The K box, a conserved 3′-UTR sequence motif, negatively regulates accumulation of Enhancer of split complex transcripts, Development, 125, 4077, 10.1242/dev.125.20.4077 Laskowski, 1980, Protein inhibitors of proteinases, Annu. Rev. Biochem., 49, 593, 10.1146/annurev.bi.49.070180.003113 Lecourtois, 1995, The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling, Genes Dev., 9, 2598, 10.1101/gad.9.21.2598 Lee, 1997, Basic helix-loop-helix genes in neural development, Curr. Opin. Neurobiol., 7, 13, 10.1016/S0959-4388(97)80115-8 Lehmann, 1983, On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster, Roux Arch. Dev. Biol., 192, 62, 10.1007/BF00848482 Lehner, 1990, The roles of Drosophila cyclins A and B in mitotic control, Cell, 61, 535, 10.1016/0092-8674(90)90535-M Leviten, 1997, The Drosophila gene Bearded encodes a novel small protein and shares 3′-UTR sequence motifs with multiple Enhancer of split complex genes, Development, 124, 4039, 10.1242/dev.124.20.4039 Leviten, 1996, Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development, Dev. Biol., 176, 264, 10.1006/dbio.1996.0133 Maier, 1993, Drosophila evolution challenges postulated redundancy in the E(spl) gene complex, Proc. Natl. Acad. Sci. USA, 90, 5464, 10.1073/pnas.90.12.5464 Micchelli, 1997, The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate, Development, 124, 1485, 10.1242/dev.124.8.1485 Poole, 1985, The engrailed locus of Drosophila: structural analysis of an embryonic transcript, Cell, 40, 37, 10.1016/0092-8674(85)90306-X Preiss, 1988, The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila, EMBO, J 7, 3917, 10.1002/j.1460-2075.1988.tb03278.x Rupp, 1991, Structure and expression of a rat agrin, Neuron, 6, 811, 10.1016/0896-6273(91)90177-2 Rushlow, 1989, The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc, EMBO J., 8, 3095, 10.1002/j.1460-2075.1989.tb08461.x Sambrook, J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. Schrons, 1992, The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells, Genetics, 132, 481, 10.1093/genetics/132.2.481 Singson, 1994, Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling, Genes Dev., 8, 2058, 10.1101/gad.8.17.2058 Strasburger, 1932, Bau, Funktion und Variabilität des Darmtraktus von Drosophila melanogaster Meigen, Z. wiss. Zool., 140, 539 Tautz, 1989, A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback, Chromosoma, 98, 81, 10.1007/BF00291041 Tepass, 1995, Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm, Development, 121, 393, 10.1242/dev.121.2.393 Ziemer, 1988, Genetic analysis of Enhancer of split, a locus involved in neurogenesis in Drosophila melanogaster, Genetics, 119, 63, 10.1093/genetics/119.1.63