The Effect of Trimethoprim on Serum Creatinine

Wiley - Tập 57 Số 3 - Trang 265-268 - 1985
Jens Kastrup1,2, Pelle Trier Petersen1,3, R Bartram1,4, Jesper Melchior Hansen1,5
1Department of Internal Medicine and Endocrinology: Department of Clinical Chemistry, Herlev University Hospital, Herlev, Denmark
2J. Kastrup, MD, Investigator, Department of Internal Medicine and Endocrinology and Department of Clinical Chemistry.
3P. Petersen, MD, Investigator, Department of Internal Medicine and Endocrinology.
4R. Bartram, MD, Investigator, Department of Internal Medicine and Endocrinology.
5J. Mölholm Hansen, MD, Consultant Physician in Charge, Department of Internal Medicine and Endocrinology.

Tóm tắt

Summary— The influence of trimethoprim on renal function has been investigated in two groups of volunteers, both without a history of either acute or chronic urinary tract disease. All had normal serum creatinine. They were treated with trimethoprim 200 mg bd for 14 days. In group A (median age 78 years), serum creatinine increased significantly from median 89 to 134 μmol/l (P < 0.01) during the first week and returned to normal 1 week after termination of treatment to median 90 μm/l (P < 0.02). After 1 week's treatment in group B (median age 29 years), serum creatinine had increased significantly from median 87 to 107 μmol/l (P < 0.05), remained stable in the second week and returned to the pre‐treatment level 1 week after cessation of treatment: 87 μmol/l (P < 0.05). The glomerular filtration rate determined by 51Cr‐EDTA clearance did not change. There was a significant decrease in the 24‐h endogenous creatinine clearance after 14 days' treatment from 111 to 87 ml/min/l.73 m2 (P < 0.05). Our results are consistent with an age‐independent reversible trimethoprim‐induced inhibition of the tubular secretion of creatinine.

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Tài liệu tham khảo

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Wiley

Tập 57 Số 3

265-268

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