The Effect of Lubricants on Powder Flowability for Pharmaceutical Application

AAPS PharmSciTech - Tập 14 Số 3 - Trang 1158-1168 - 2013
Garett Morin1, Lauren Briens2
1Biomedical Engineering Graduate Program, The University of Western Ontario, London, N6A 5B9, Canada.
2Chemical Engineering, The University of Western Ontario, London, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Wang J, Wen H, Desai D. Lubrication in tablet formulations. Eur J Pharm Biopharm. 2010;75(1):1–15.

Perrault M, Bertrand F, Chaouki J. An investigation of magnesium stearate mixing in a V-blender through gamma-ray detection. Powder Techn. 2010;200(3):234–45.

Alderborn G. Tablet and compaction. In: Aulton ME, editor. Pharmaceutics: the science of dosage form design. 2nd ed. London: Churchill Livingstone; 2002. p. 397–448.

Dawoodbhai S, Rhodes CT. Pharmaceutical and cosmetic uses of talc. Drug Dev Ind Pharm. 1990;16(16):2409–29.

Dawoodbhai TS, Suryanarayan E, Woodruff C, Rhodes C. Optimization of tablet formulations containing. Drug Dev Ind Pharm. 1991;17(10):1343–71.

Wang DP, Yang MC, Wong CY. Formulation development of oral controlled-release pellets of diclofenac sodium. Drug Dev Ind Pharm. 1997;23(10):1013–7.

Asker A, Saied K, Abdel-Khalek M. Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 5: effects of lubricants and flow conditions. Die Pharmazie. 1975;30(6):378.

Jarosz PJ, Parrott EL. Effect of lubricants on tensile strengths of tablets. Drug Dev Ind Pharm. 1984;10(2):259–73.

Mitrevej A, Sinchaipanid N, Faroongsarng D. Spray-dried rice starch: comparative evaluation of direct compression fillers. Drug Dev Ind Pharm. 1996;22(7):587–94.

Johansson M. Investigations of the mixing time dependence of the lubricating properties of granular and powdered magnesium stearate. Acta Pharm Suec. 1985;22(6):343.

Johansson ME. Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. J Pharm Pharmacol. 1985;37(10):681–5.

Johansson M, Astra Laekemedel A, Soedertaelje S. The effect of scaling-up of the mixing process on the lubricating effect of powdered and granular magnesium stearate. Acta Pharm Tech. 1986;32(1):39–42.

Nalluri VR, Kuentz M. Flowability characterisation of drug-excipient blends using a novel powder avalanching method. Eur J Pharm Biopharm. 2010;74(2):388–96.

Faqih AMN, Mehrotra A, Hammond SV, Muzzio FJ. Effect of moisture and magnesium stearate concentration on flow properties of cohesive granular materials. Int J Pharm. 2007;336(2):338–45.

Lim SY, Davidson J, Forster R, Parker D, Scott D, Seville J. Avalanching of granular material in a horizontal slowly rotating cylinder: PEPT studies. Powder Tech. 2003;138(1):25–30.

Fassihi A, Kanfer I. Effect of compressibility and powder flow properties on tablet weight variation. Drug Dev Ind Pharm. 1986;12(11–13):1947–66.

Tan S, Newton J. Powder flowability as an indication of capsule filling performance. Int J Pharm. 1990;61(1–2):145–55.

Sandler N, Wilson D. Prediction of granule packing and flow behavior based on particle size and shape analysis. J Pharm Sci. 2010;99(2):958–68.

Amidon GE. Physical and mechanical property characterization of powders. In: Brittain HG, editor. Physical characterization of pharmaceutical solids. Zug: Informa Healthcare; 1995. p. 281–319.

Liu LX, Marziano I, Bentham A, Litster JD, White E, Howes T. Effect of particle properties on the flowability of ibuprofen powders. Int J Pharm. 2008;362(1):109–17.

Pingali KC, Saranteas K, Foroughi R, Muzzio FJ. Practical methods for improving flow properties of active pharmaceutical ingredients. Drug Dev Ind Pharm. 2009;35(12):1460–9.

Roblot-Treupel L, Puisieux F. Distribution of magnesium stearate on the surface of lubricated particles. Int J Pharm. 1986;31(1):131–6.

Carr RL. Evaluating flow properties of solids. Chem Eng. 1965;72:163–8.

Nagel KM, Peck GE. Investigating the effects of excipients on the powder flow characteristics of theophylline anhydrous powder formulations. Drug Dev Ind Pharm. 2003;29(3):277–87.

Li Q, Rudolph V, Weigl B, Earl A. Interparticle van der Waals force in powder flowability and compactibility. Int J Pharm. 2004;280(1–2):77–93.

Kikuta JI, Kitamori N. Effect of mixing time on the lubricating properties of magnesium stearate and the final characteristics of the compressed tablets. Drug Dev Ind Pharm. 1994;20(3):343–55.

Bossert J, Stains A. Effect of mixing on the lubrication of crystalline lactose by magnesium stearate. Drug Dev Ind Pharm. 1980;6(6):573–89.