The ESCRT Pathway

Developmental Cell - Tập 21 Số 1 - Trang 77-91 - 2011
William Mike Henne1,2, Nicholas J. Buchkovich1,2, Scott D. Emr1,2
1Department of Molecular Biology and Genetics, Cornell University, Weill Hall, Ithaca, NY 14853, USA
2Weill Institute for Cell and Molecular Biology, Cornell University, Weill Hall, Ithaca, NY 14853, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Agromayor, 2009, Essential role of hIST1 in cytokinesis, Mol. Biol. Cell, 20, 1374, 10.1091/mbc.E08-05-0474

Alam, 2004, Ubiquitin interactions of NZF zinc fingers, EMBO J., 23, 1411, 10.1038/sj.emboj.7600114

Amerik, 2000, The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways, Mol. Biol. Cell, 11, 3365, 10.1091/mbc.11.10.3365

Amit, 2004, Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding, Genes Dev., 18, 1737, 10.1101/gad.294904

Asao, 1997, Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth, J. Biol. Chem., 272, 32785, 10.1074/jbc.272.52.32785

Azmi, 2006, Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1, J. Cell Biol., 172, 705, 10.1083/jcb.200508166

Azmi, 2008, ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1, Dev. Cell, 14, 50, 10.1016/j.devcel.2007.10.021

Babst, 2005, A protein's final ESCRT, Traffic, 6, 2, 10.1111/j.1600-0854.2004.00246.x

Babst, 1997, Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p, EMBO J., 16, 1820, 10.1093/emboj/16.8.1820

Babst, 1998, The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function, EMBO J., 17, 2982, 10.1093/emboj/17.11.2982

Babst, 2002, Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting, Dev. Cell, 3, 271, 10.1016/S1534-5807(02)00220-4

Babst, 2002, Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body, Dev. Cell, 3, 283, 10.1016/S1534-5807(02)00219-8

Bache, 2003, STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes, J. Biol. Chem., 278, 12513, 10.1074/jbc.M210843200

Bache, 2004, The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation, Mol. Biol. Cell, 15, 4337, 10.1091/mbc.E04-03-0250

Bajorek, 2009, Biochemical analyses of human IST1 and its function in cytokinesis, Mol. Biol. Cell, 20, 1360, 10.1091/mbc.E08-05-0475

Bajorek, 2009, Structural basis for ESCRT-III protein autoinhibition, Nat. Struct. Mol. Biol., 16, 754, 10.1038/nsmb.1621

Banta, 1988, Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting, J. Cell Biol., 107, 1369, 10.1083/jcb.107.4.1369

Barends, 2010, Disaggregases in 4 dimensions, Curr. Opin. Struct. Biol., 20, 46, 10.1016/j.sbi.2009.12.014

Bashkirov, 2008, GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission, Cell, 135, 1276, 10.1016/j.cell.2008.11.028

Bilodeau, 2002, The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting, Nat. Cell Biol., 4, 534, 10.1038/ncb815

Bishop, 2001, TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes, J. Biol. Chem., 276, 11735, 10.1074/jbc.M009863200

Bouamr, 2007, The C-terminal portion of the Hrs protein interacts with Tsg101 and interferes with human immunodeficiency virus type 1 Gag particle production, J. Virol., 81, 2909, 10.1128/JVI.01413-06

Burton, 2001, ClpX-mediated remodeling of mu transpososomes: selective unfolding of subunits destabilizes the entire complex, Mol. Cell, 8, 449, 10.1016/S1097-2765(01)00307-0

Carlton, 2010, The ESCRT machinery: a cellular apparatus for sorting and scission, Biochem. Soc. Trans., 38, 1397, 10.1042/BST0381397

Carlton, 2007, Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery, Science, 316, 1908, 10.1126/science.1143422

Carlton, 2008, Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release, Proc. Natl. Acad. Sci. USA, 105, 10541, 10.1073/pnas.0802008105

Carpp, 2011, Interaction between the yellow fever virus nonstructural protein NS3 and the host protein Alix contributes to the release of infectious particles, Microbes Infect., 13, 85, 10.1016/j.micinf.2010.10.010

Chen, 2008, Mechanisms for enveloped virus budding: can some viruses do without an ESCRT?, Virology, 372, 221, 10.1016/j.virol.2007.11.008

Chu, 2006, New component of ESCRT-I regulates endosomal sorting complex assembly, J. Cell Biol., 175, 815, 10.1083/jcb.200608053

Curtiss, 2007, Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12, Mol. Biol. Cell, 18, 636, 10.1091/mbc.E06-07-0588

Danilchik, 1998, Requirement for microtubules in new membrane formation during cytokinesis of Xenopus embryos, Dev. Biol., 194, 47, 10.1006/dbio.1997.8815

Doherty, 2009, Mechanisms of endocytosis, Annu. Rev. Biochem., 78, 857, 10.1146/annurev.biochem.78.081307.110540

Dukes, 2008, A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes, Biochem. J., 411, 233, 10.1042/BJ20071296

Eastman, 2005, Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding, J. Biol. Chem., 280, 628, 10.1074/jbc.M410384200

Elia, 2011, Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission, Proc. Natl. Acad. Sci. USA, 108, 4846, 10.1073/pnas.1102714108

Fabrikant, 2009, Computational model of membrane fission catalyzed by ESCRT-III, PLoS Comput. Biol., 5, e1000575, 10.1371/journal.pcbi.1000575

Filimonenko, 2007, Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease, J. Cell Biol., 179, 485, 10.1083/jcb.200702115

Fisher, 2003, Structure and ubiquitin binding of the ubiquitin-interacting motif, J. Biol. Chem., 278, 28976, 10.1074/jbc.M302596200

Gallop, 2005, BAR domains and membrane curvature: bringing your curves to the BAR, Biochem. Soc. Symp., 72, 223, 10.1042/bss0720223

Garrus, 2001, Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding, Cell, 107, 55, 10.1016/S0092-8674(01)00506-2

Gerald, 2001, Cytokinesis failure in clathrin-minus cells is caused by cleavage furrow instability, Cell Motil. Cytoskeleton, 48, 213, 10.1002/1097-0169(200103)48:3<213::AID-CM1010>3.0.CO;2-V

Ghazi-Tabatabai, 2008, Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24, Structure, 16, 1345, 10.1016/j.str.2008.06.010

Gill, 2007, Structural insight into the ESCRT-I/-II link and its role in MVB trafficking, EMBO J., 26, 600, 10.1038/sj.emboj.7601501

Gonciarz, 2008, Biochemical and structural studies of yeast Vps4 oligomerization, J. Mol. Biol., 384, 878, 10.1016/j.jmb.2008.09.066

Gromley, 2005, Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission, Cell, 123, 75, 10.1016/j.cell.2005.07.027

Guizetti, 2011, Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments, Science, 331, 1616, 10.1126/science.1201847

Haigler, 1979, Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431, J. Cell Biol., 81, 382, 10.1083/jcb.81.2.382

Hanson, 2008, Plasma membrane deformation by circular arrays of ESCRT-III protein filaments, J. Cell Biol., 180, 389, 10.1083/jcb.200707031

Henne, 2007, Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature, Structure, 15, 839, 10.1016/j.str.2007.05.002

Hierro, 2004, Structure of the ESCRT-II endosomal trafficking complex, Nature, 431, 221, 10.1038/nature02914

Hinshaw, 1995, Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding, Nature, 374, 190, 10.1038/374190a0

Hirano, 2006, Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting, Nat. Struct. Mol. Biol., 13, 272, 10.1038/nsmb1051

Hoeller, 2006, Regulation of ubiquitin-binding proteins by monoubiquitination, Nat. Cell Biol., 8, 163, 10.1038/ncb1354

Hurley, 2010, Membrane budding, Cell, 143, 875, 10.1016/j.cell.2010.11.030

Im, 2008, Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex, Dev. Cell, 14, 902, 10.1016/j.devcel.2008.04.004

Jouvenet, 2011, Dynamics of ESCRT protein recruitment during retroviral assembly, Nat. Cell Biol., 13, 394, 10.1038/ncb2207

Kaksonen, 2005, A modular design for the clathrin- and actin-mediated endocytosis machinery, Cell, 123, 305, 10.1016/j.cell.2005.09.024

Katzmann, 2001, Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I, Cell, 106, 145, 10.1016/S0092-8674(01)00434-2

Katzmann, 2003, Vps27 recruits ESCRT machinery to endosomes during MVB sorting, J. Cell Biol., 162, 413, 10.1083/jcb.200302136

Katzmann, 2004, Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S, Mol. Biol. Cell, 15, 468, 10.1091/mbc.E03-07-0473

Kim, 2007, Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking, Mol. Biol. Cell, 18, 1129, 10.1091/mbc.E06-09-0787

Kostelansky, 2006, Structural and functional organization of the ESCRT-I trafficking complex, Cell, 125, 113, 10.1016/j.cell.2006.01.049

Kostelansky, 2007, Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer, Cell, 129, 485, 10.1016/j.cell.2007.03.016

Kyuuma, 2007, AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes, Cell Struct. Funct., 31, 159, 10.1247/csf.06023

Langelier, 2006, Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release, J. Virol., 80, 9465, 10.1128/JVI.01049-06

Lata, 2008, Helical structures of ESCRT-III are disassembled by VPS4, Science, 321, 1354, 10.1126/science.1161070

Lee, 2005, Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle, Cell, 122, 605, 10.1016/j.cell.2005.07.025

Lee, 2007, ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration, Curr. Biol., 17, 1561, 10.1016/j.cub.2007.07.029

Lenz, 2009, Membrane buckling induced by curved filaments, Phys. Rev. Lett., 103, 038101, 10.1103/PhysRevLett.103.038101

Leung, 2008, Evolution of the multivesicular body ESCRT machinery; retention across the eukaryotic lineage, Traffic, 9, 1698, 10.1111/j.1600-0854.2008.00797.x

Lindås, 2008, A unique cell division machinery in the Archaea, Proc. Natl. Acad. Sci. USA, 105, 18942, 10.1073/pnas.0809467105

Long, 2010, Sar1 assembly regulates membrane constriction and ER export, J. Cell Biol., 190, 115, 10.1083/jcb.201004132

Lu, 2003, TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation, Proc. Natl. Acad. Sci. USA, 100, 7626, 10.1073/pnas.0932599100

Luhtala, 2004, Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes, J. Cell Biol., 166, 717, 10.1083/jcb.200403139

Lundmark, 2008, Arf family GTP loading is activated by, and generates, positive membrane curvature, Biochem. J., 414, 189, 10.1042/BJ20081237

Mao, 2000, Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction, Cell, 100, 447, 10.1016/S0092-8674(00)80680-7

Martin-Serrano, 2001, HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress, Nat. Med., 7, 1313, 10.1038/nm1201-1313

Matsuo, 2004, Role of LBPA and Alix in multivesicular liposome formation and endosome organization, Science, 303, 531, 10.1126/science.1092425

McCullough, 2006, Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery, Curr. Biol., 16, 160, 10.1016/j.cub.2005.11.073

Mizuno, 2003, STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif, Mol. Biol. Cell, 14, 3675, 10.1091/mbc.E02-12-0823

Morita, 2007, Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding, Cell Host Microbe, 2, 41, 10.1016/j.chom.2007.06.003

Morita, 2010, Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance, Proc. Natl. Acad. Sci. USA, 107, 12889, 10.1073/pnas.1005938107

Muzioł, 2006, Structural basis for budding by the ESCRT-III factor CHMP3, Dev. Cell, 10, 821, 10.1016/j.devcel.2006.03.013

Neuwald, 1999, AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes, Genome Res., 9, 27, 10.1101/gr.9.1.27

Odorizzi, 1998, Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body, Cell, 95, 847, 10.1016/S0092-8674(00)81707-9

Odorizzi, 2003, Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae, J. Cell Sci., 116, 1893, 10.1242/jcs.00395

Palade, 1955, Studies on the endoplasmic reticulum. II. Simple dispositions in cells in situ, J. Biophys. Biochem. Cytol., 1, 567, 10.1083/jcb.1.6.567

Peter, 2004, BAR domains as sensors of membrane curvature: the amphiphysin BAR structure, Science, 303, 495, 10.1126/science.1092586

Pires, 2009, A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments, Structure, 17, 843, 10.1016/j.str.2009.04.007

Polo, 2002, A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins, Nature, 416, 451, 10.1038/416451a

Pornillos, 2002, Structure and functional interactions of the Tsg101 UEV domain, EMBO J., 21, 2397, 10.1093/emboj/21.10.2397

Pornillos, 2003, HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein, J. Cell Biol., 162, 425, 10.1083/jcb.200302138

Prag, 2007, The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting, Dev. Cell, 12, 973, 10.1016/j.devcel.2007.04.013

Raiborg, 2009, The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins, Nature, 458, 445, 10.1038/nature07961

Raiborg, 2001, FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes, J. Cell Sci., 114, 2255, 10.1242/jcs.114.12.2255

Raiborg, 2002, Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes, Nat. Cell Biol., 4, 394, 10.1038/ncb791

Raiborg, 2006, Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains, J. Cell Sci., 119, 2414, 10.1242/jcs.02978

Ramachandran, 2009, Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission, Mol. Biol. Cell, 20, 4630, 10.1091/mbc.E09-08-0683

Raymond, 1992, Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants, Mol. Biol. Cell, 3, 1389, 10.1091/mbc.3.12.1389

Reggiori, 2001, Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting, EMBO J., 20, 5176, 10.1093/emboj/20.18.5176

Reid, 2001, ClpA mediates directional translocation of substrate proteins into the ClpP protease, Proc. Natl. Acad. Sci. USA, 98, 3768, 10.1073/pnas.071043698

Ren, 2010, VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo, EMBO J., 29, 1045, 10.1038/emboj.2010.6

Ren, 2009, Hybrid structural model of the complete human ESCRT-0 complex, Structure, 17, 406, 10.1016/j.str.2009.01.012

Robinson, 1988, Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases, Mol. Cell. Biol., 8, 4936, 10.1128/MCB.8.11.4936

Rothman, 1986, Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway, Cell, 47, 1041, 10.1016/0092-8674(86)90819-6

Rothman, 1996, Protein sorting by transport vesicles, Science, 272, 227, 10.1126/science.272.5259.227

Rothman, 1989, Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae, EMBO J., 8, 2057, 10.1002/j.1460-2075.1989.tb03614.x

Roux, 2006, GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission, Nature, 441, 528, 10.1038/nature04718

Row, 2006, The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation, J. Biol. Chem., 281, 12618, 10.1074/jbc.M512615200

Rue, 2008, Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting, Mol. Biol. Cell, 19, 475, 10.1091/mbc.E07-07-0694

Rusten, 2007, ESCRTs and Fab1 regulate distinct steps of autophagy, Curr. Biol., 17, 1817, 10.1016/j.cub.2007.09.032

Sachse, 2002, Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes, Mol. Biol. Cell, 13, 1313, 10.1091/mbc.01-10-0525

Saksena, 2009, ESCRTs and human disease, Biochem. Soc. Trans., 37, 167, 10.1042/BST0370167

Saksena, 2009, Functional reconstitution of ESCRT-III assembly and disassembly, Cell, 136, 97, 10.1016/j.cell.2008.11.013

Samson, 2011, Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division, Mol. Cell, 41, 186, 10.1016/j.molcel.2010.12.018

Scott, 2005, Structural and mechanistic studies of VPS4 proteins, EMBO J., 24, 3658, 10.1038/sj.emboj.7600818

Scott, 2005, Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A, Proc. Natl. Acad. Sci. USA, 102, 13813, 10.1073/pnas.0502165102

Shestakova, 2010, Assembly of the AAA ATPase Vps4 on ESCRT-III, Mol. Biol. Cell, 21, 1059, 10.1091/mbc.E09-07-0572

Shields, 2009, ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting, J. Cell Biol., 185, 213, 10.1083/jcb.200811130

Shiflett, 2004, Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae, J. Biol. Chem., 279, 10982, 10.1074/jbc.M312669200

Shih, 2002, Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis, Nat. Cell Biol., 4, 389, 10.1038/ncb790

Shim, 2007, Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain, Traffic, 8, 1068, 10.1111/j.1600-0854.2007.00584.x

Shimoni, 2002, Vesicle budding from endoplasmic reticulum, Methods Enzymol., 351, 258, 10.1016/S0076-6879(02)51852-8

Sierra, 2010, AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4, J. Biol. Chem., 285, 13990, 10.1074/jbc.M109.061309

Slagsvold, 2005, Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain, J. Biol. Chem., 280, 19600, 10.1074/jbc.M501510200

Sotelo, 1959, An electron microscope study of the rat ovum, J. Biophys. Biochem. Cytol., 5, 327, 10.1083/jcb.5.2.327

Spitzer, 2006, The Arabidopsis elch mutant reveals functions of an ESCRT component in cytokinesis, Development, 133, 4679, 10.1242/dev.02654

Stowell, 1999, Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring, Nat. Cell Biol., 1, 27, 10.1038/8997

Strack, 2000, A role for ubiquitin ligase recruitment in retrovirus release, Proc. Natl. Acad. Sci. USA, 97, 13063, 10.1073/pnas.97.24.13063

Striebel, 2009, Controlled destruction: AAA+ ATPases in protein degradation from bacteria to eukaryotes, Curr. Opin. Struct. Biol., 19, 209, 10.1016/j.sbi.2009.02.006

Stringer, 2011, A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination, J. Cell Biol., 192, 229, 10.1083/jcb.201008121

Stuchell, 2004, The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding, J. Biol. Chem., 279, 36059, 10.1074/jbc.M405226200

Swaminathan, 1999, The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast, Mol. Biol. Cell, 10, 2583, 10.1091/mbc.10.8.2583

Teis, 2008, Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation, Dev. Cell, 15, 578, 10.1016/j.devcel.2008.08.013

Teis, 2010, ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation, EMBO J., 29, 871, 10.1038/emboj.2009.408

Teo, 2004, ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes, Dev. Cell, 7, 559, 10.1016/j.devcel.2004.09.003

Teo, 2006, ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes, Cell, 125, 99, 10.1016/j.cell.2006.01.047

Trajkovic, 2008, Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science, 319, 1244, 10.1126/science.1153124

Tsunematsu, 2010, Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications, Biochem. Biophys. Res. Commun., 399, 232, 10.1016/j.bbrc.2010.07.060

Urata, 2007, Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP, J. Virol., 81, 4895, 10.1128/JVI.02829-06

VerPlank, 2001, Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag), Proc. Natl. Acad. Sci. USA, 98, 7724, 10.1073/pnas.131059198

Weber-Ban, 1999, Global unfolding of a substrate protein by the Hsp100 chaperone ClpA, Nature, 401, 90, 10.1038/43481

Wemmer, 2011, Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast, J. Cell Biol., 192, 295, 10.1083/jcb.201007018

Williams, 2007, The emerging shape of the ESCRT machinery, Nat. Rev. Mol. Cell Biol., 8, 355, 10.1038/nrm2162

Wirblich, 2006, Nonstructural protein 3 of bluetongue virus assists virus release by recruiting ESCRT-I protein Tsg101, J. Virol., 80, 460, 10.1128/JVI.80.1.460-473.2006

Wollert, 2010, Molecular mechanism of multivesicular body biogenesis by ESCRT complexes, Nature, 464, 864, 10.1038/nature08849

Wollert, 2009, Membrane scission by the ESCRT-III complex, Nature, 458, 172, 10.1038/nature07836

Yang, 2008, Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B, Nat. Struct. Mol. Biol., 15, 1278, 10.1038/nsmb.1512

Yu, 2008, Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p, J. Mol. Biol., 377, 364, 10.1016/j.jmb.2008.01.009

Zamborlini, 2006, Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding, Proc. Natl. Acad. Sci. USA, 103, 19140, 10.1073/pnas.0603788103