The EMT-related transcription factor snail up-regulates FAPα in malignant melanoma cells

Garbe, 2010, Diagnosis and treatment of melanoma: european consensus-based interdisciplinary guideline, Eur. J. Cancer, 46, 270, 10.1016/j.ejca.2009.10.032 Miller, 2006, Melanoma, N. Engl. J. Med., 355, 51, 10.1056/NEJMra052166 Fang, 2013, Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma, Cancer Lett., 333, 66, 10.1016/j.canlet.2013.01.014 Cheng, 2002, Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model, Cancer Res., 62, 4767 Garin-Chesa, 1990, Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers, Proc. Natl. Acad. Sci. USA, 87, 7235, 10.1073/pnas.87.18.7235 Huber, 2003, Fibroblast activation protein: differential expression and serine protease activity in reactive stromal fibroblasts of melanocytic skin tumors, J. Invest Dermatol., 120, 182, 10.1046/j.1523-1747.2003.12035.x Kelly, 2005, Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy, Drug Resist Updat., 8, 51, 10.1016/j.drup.2005.03.002 Wen, 2017, Fibroblast activation protein-alpha-positive fibroblasts promote gastric cancer progression and resistance to immune checkpoint blockade, Oncol. Res., 25, 629, 10.3727/096504016X14768383625385 Zhang, 2016, Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors, Oncotarget, 7, 23282, 10.18632/oncotarget.7818 Chen, 2015, A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts, Sci. Rep., 5, 14421, 10.1038/srep14421 Andrew, 2003, A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer, Clin. Cancer Res., 9, 1639 Errarte, 2016, The expression of fibroblast activation protein in clear cell renal cell carcinomas is associated with synchronous lymph node metastases, PLoS One, 11, e0169105, 10.1371/journal.pone.0169105 Goodman, 2003, Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells, Clin. Exp. Metastas-., 20, 459, 10.1023/A:1025493605850 Jun Jia, 2014, FAP-α (fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway, BMC Cell Biol., 15, 16, 10.1186/1471-2121-15-16 Mori, 2004, The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma, Oncology, 67, 411, 10.1159/000082926 Waster, 2011, Ultraviolet exposure of melanoma cells induces fibroblast activation protein-alpha in fibroblasts: implications for melanoma invasion, Int J. Oncol., 39, 193 Thiery, 2006, Complex networks orchestrate epithelial-mesenchymal transitions, Nat. Rev. Mol. Cell Biol., 7, 131, 10.1038/nrm1835 Thiery, 2009, Epithelial-mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007 Christofori, 2006, New signals from the invasive front, Nature, 441, 444, 10.1038/nature04872 Alonso, 2007, A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis, Cancer Res., 67, 3450, 10.1158/0008-5472.CAN-06-3481 Peinado, 2007, Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nat. Rev. Cancer, 7, 415, 10.1038/nrc2131 Guo, 2015, Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo, Am. J. Cancer Res., 5, 2098 Kudo-Saito, 2009, Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells, Cancer Cell., 15, 195, 10.1016/j.ccr.2009.01.023 Lin, 2017, C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling, J. Mol. Med (Berl.)., 95, 53, 10.1007/s00109-016-1452-x Zeng, 2017, MicroRNA-153-3p suppress cell proliferation and invasion by targeting SNAI1 in melanoma, Biochem Biophys. Res Commun., 487, 140, 10.1016/j.bbrc.2017.04.032 Wang, 2013, Epithelial-mesenchymal transition (EMT) induced by TNF-alpha requires AKT/GSK-3beta-mediated stabilization of snail in colorectal cancer, PLoS One, 8, e56664, 10.1371/journal.pone.0056664 Ewa Aladowicz, 2013, Molecular networks in melanoma invasion and metastasis, Future Oncol., 9, 713, 10.2217/fon.13.9 Haass, 2005, Adhesion, migration and communication in melanocytes and melanoma, Pigment Cell Res., 18, 150, 10.1111/j.1600-0749.2005.00235.x Leong, 2011, Cutaneous melanoma: a model to study cancer metastasis, J. Surg. Oncol., 103, 538, 10.1002/jso.21816 Cheng, 2005, Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth, Mol. Cancer Ther., 4, 351, 10.1158/1535-7163.MCT-04-0269 Chung, 2014, Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation, PLoS One, 9, e88772, 10.1371/journal.pone.0088772 Wang, 2014, Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma, Cell Death Dis., 5, e1155, 10.1038/cddis.2014.122 Waster, 2017, UV radiation promotes melanoma dissemination mediated by the sequential reaction axis of cathepsins-TGF-beta1-FAP-alpha, Br. J. Cancer, 117, 535, 10.1038/bjc.2017.182 Mikheeva, 2010, TWIST1 promotes invasion through mesenchymal change in human glioblastoma, Mol. Cancer, 9, 194, 10.1186/1476-4598-9-194 Henriksson, 2011, Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion, Am. J. Pathol., 178, 1387, 10.1016/j.ajpath.2010.12.008 Batlle, 2000, The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nat. Cell Biol., 2, 84, 10.1038/35000034 Cano, 2000, The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression, Nat. Cell Biol., 2, 76, 10.1038/35000025 Dong, 2012, G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer, J. Clin. Invest., 122, 1469, 10.1172/JCI57349 Yang, 2004, Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis, Cell, 117, 927, 10.1016/j.cell.2004.06.006 Ansieau, 2008, Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence, Cancer Cell., 14, 79, 10.1016/j.ccr.2008.06.005 Barrallo-Gimeno, 2005, The Snail genes as inducers of cell movement and survival: implications in development and cancer, Development, 132, 3151, 10.1242/dev.01907 Olmeda, 2007, Snail silencing effectively suppresses tumour growth and invasiveness, Oncogene, 26, 1862, 10.1038/sj.onc.1209997 Taki, 2006, Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells, Int J. Oncol., 28, 487 Hajra, 2002, The SLUG zinc-finger protein represses E-cadherin in breast cancer, Cancer Res., 62, 1613 Tulley, 2014, Transcriptional regulation of seprase in invasive melanoma cells by transforming growth Factor- signaling, J. Biol. Chem., 289, 15280, 10.1074/jbc.M114.568501