The EGF receptor inhibits the signaling of dopamine D 3 receptor through the phosphorylation of GRK2 on tyrosine residues

van Biesen, 1995, Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway, Nature, 376, 781, 10.1038/376781a0 Daub, 1996, Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors, Nature, 379, 557, 10.1038/379557a0 Chen, 2008, EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation, Mol. Biol. Cell, 19, 2973, 10.1091/mbc.E07-10-1058 Casas-Gonzalez, 2006, Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation, Eur. J. Pharmacol., 542, 31, 10.1016/j.ejphar.2006.05.031 Rodriguez-Perez, 2009, Receptor tyrosine kinases regulate alpha1D-adrenoceptor signaling properties: phosphorylation and desensitization, Int. J. Biochem. Cell Biol., 41, 1276, 10.1016/j.biocel.2008.10.030 Cattaneo, 2014, Cell-surface receptors transactivation mediated by g protein-coupled receptors, Int. J. Mol. Sci., 15, 19700, 10.3390/ijms151119700 Cattaneo, 2013, WKYMVm-induced cross-talk between FPR2 and HGF receptor in human prostate epithelial cell line PNT1A, FEBS Lett., 587, 1536, 10.1016/j.febslet.2013.03.036 Yamada, 1997, The neurotrophic action and signalling of epidermal growth factor, Prog. Neurobiol., 51, 19, 10.1016/S0301-0082(96)00046-9 Buonanno, 2001, Neuregulin and ErbB receptor signaling pathways in the nervous system, Curr. Opin. Neurobiol., 11, 287, 10.1016/S0959-4388(00)00210-5 Oyagi, 2012, Essential roles of heparin-binding epidermal growth factor-like growth factor in the brain, CNS Neurosci. Ther., 18, 803, 10.1111/j.1755-5949.2012.00371.x Freedman, 2002, Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization, J. Biol. Chem., 277, 48261, 10.1074/jbc.M204431200 Futamura, 2002, Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients, Mol. Psychiatry, 7, 673, 10.1038/sj.mp.4001081 Farkas, 2010, Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia, World J. Biol. Psychiatry, 11, 556, 10.3109/15622970903497936 Nemeroff, 1988, Neuropeptides, dopamine, and schizophrenia, Ann. N. Y. Acad. Sci., 537, 273, 10.1111/j.1749-6632.1988.tb42113.x Seeman, 1987, Dopamine receptors and the dopamine hypothesis of schizophrenia, Synapse, 1, 133, 10.1002/syn.890010203 Missale, 1998, Dopamine receptors: from structure to function, Physiol. Rev., 78, 189, 10.1152/physrev.1998.78.1.189 Iversen, 2007, Dopamine: 50 years in perspective, Trends Neurosci., 30, 188, 10.1016/j.tins.2007.03.002 Sibley, 1999, New insights into dopaminergic receptor function using antisense and genetically altered animals, Annu. Rev. Pharmacol. Toxicol., 39, 313, 10.1146/annurev.pharmtox.39.1.313 Cho, 2012, Identification of cis-acting elements and signaling components of high affinity IgE receptor that regulate the expression of cyclooxygenase-2, Cell Physiol. Biochem., 29, 725, 10.1159/000171028 Civelli, 1993, Molecular diversity of the dopamine receptors, Annu. Rev. Pharmacol. Toxicol., 33, 281, 10.1146/annurev.pa.33.040193.001433 Cho, 2010, Current perspectives on the selective regulation of dopamine D(2) and D(3) receptors, Arch. Pharm. Res., 33, 1521, 10.1007/s12272-010-1005-8 Gurevich, 1999, Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons, Neuropsychopharmacology, 20, 60, 10.1016/S0893-133X(98)00066-9 Zheng, 2016, RalA employs GRK2 and beta-arrestins for the filamin A-mediated regulation of trafficking and signaling of dopamine D and D receptor, Biochim. Biophys. Acta, 1863, 2072, 10.1016/j.bbamcr.2016.05.010 Zheng, 2016, Agonist-induced changes in RalA activities allows the prediction of the endocytosis of G protein-coupled receptors, Biochim. Biophys. Acta, 1863, 77, 10.1016/j.bbamcr.2015.10.007 Jiang, 2010, Crucial roles for protein kinase C isoforms in tumor-specific killing by apoptin, Cancer Res., 70, 7242, 10.1158/0008-5472.CAN-10-1204 Zheng, 2011, beta-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation, Mol. Cell Biol., 31, 4887, 10.1128/MCB.05690-11 Kim, 2001, Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins, J. Biol. Chem., 276, 37409, 10.1074/jbc.M106728200 Cho, 2010, Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D(2) receptors, Mol. Endocrinol., 24, 574, 10.1210/me.2009-0369 Jorissen, 2003, Epidermal growth factor receptor: mechanisms of activation and signalling, Exp. Cell Res., 284, 31, 10.1016/S0014-4827(02)00098-8 Zhang, 2006, An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor, Cell, 125, 1137, 10.1016/j.cell.2006.05.013 Cho, 2007, Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor, Mol. Endocrinol., 21, 2242, 10.1210/me.2007-0202 Clark, 1988, Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells, Proc. Natl. Acad. Sci. U. S. A., 85, 1442, 10.1073/pnas.85.5.1442 Freedman, 1995, Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP- dependent protein kinase, J. Biol. Chem., 270, 17953, 10.1074/jbc.270.30.17953 Sarnago, 1999, Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase, J. Biol. Chem., 274, 34411, 10.1074/jbc.274.48.34411 Bernstein, 2013, Concerning HB-EGF brain levels in schizophrenia: cellular distribution of putative sheddases may matter, CNS Neurosci. Ther., 19, 136, 10.1111/cns.12042