The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes

BioMed Research International - Tập 2014 - Trang 1-8 - 2014
Yue Gao1, Shuyun Liu1, Jingxiang Huang1, Weimin Guo1, Jifeng Chen1, Li Zhang1, Bin Zhao1, Jiang Peng1, Aiyuan Wang1, Yu Wang1, Wenjing Xu1, Shibi Lu1, Mei Yuan1, Mingjie Wang1
1Institute of Orthopedics, Chinese PLA General Hospital, Beijing, 100853, China

Tóm tắt

Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival. The major signaling pathways that regulate chondrogenesis have been identified as wnt signal, nitric oxide (NO) signal, protein kinase C (PKC), and retinoic acid (RA) signal. Integrins are a large family of molecules that are central regulators in multicellular biology. They orchestrate cell-cell and cell-matrix adhesive interactions from embryonic development to mature tissue function. In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis.

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Tài liệu tham khảo

10.1111/j.1469-8137.2010.03374.x

10.1016/j.tcb.2010.08.002

10.1007/s10856-009-3889-8

10.1007/s10735-005-9007-4

2000, Histochemistry and Cell Biology, 114, 323, 10.1007/s004180000189

2007, The extracellular matrix and cell adhesion

10.1111/j.1749-6632.2011.06227.x

10.1196/annals.1346.011

2000, Microscopy Research and Technique, 50, 236, 10.1002/1097-0029(20000801)50:3<236::AID-JEMT7>3.0.CO;2-E

2002, Biorheology, 39, 119

10.1016/j.cellbi.2008.03.016

10.1016/j.jbiosc.2008.09.020

10.1016/S0070-2153(05)69008-4

10.1002/art.22818

10.1002/jcp.21110

2005, In Vivo, 19, 501

2008, Advances in Anatomy, Embryology, and Cell Biology, 197, 1, 10.1007/978-3-540-78771-6_1

10.1016/j.biomaterials.2009.07.039

2014, Cellular Signalling, 26, 979, 10.1016/j.cellsig.2014.01.011

2013, Development, 140, 76, 10.1242/dev.080473

2013, Developmental Biology, 381, 423, 10.1016/j.ydbio.2013.06.012

10.1056/NEJM199312303292706

2014, Chemistry & Biology, 1

10.1074/jbc.M107231200

1997, Mechanisms of Development, 61, 23

10.1177/1535370213513997

1995, Journal of Histochemistry and Cytochemistry, 43, 1061, 10.1177/43.10.7560884

2000, Biorheology, 37, 109

10.1007/s004410100417

10.1016/S0092-8674(02)00971-6

10.1242/jcs.00071

10.1146/annurev.cellbio.21.090704.151217

10.1101/gad.277003

1997, Developmental Dynamics, 210, 249, 10.1002/(SICI)1097-0177(199711)210:3<249::AID-AJA6>3.0.CO;2-G

10.1074/jbc.M605937200

1993, Arthritis and Rheumatism, 36, 1103, 10.1002/art.1780360811

10.1006/excr.1994.1053

10.1007/BF01452253

10.1002/art.10334

10.1016/S0945-053X(99)00027-X

10.1093/hmg/ddm114

10.1002/art.10704

2003, Annals of the New York Academy of Sciences, 995, 109, 10.1111/j.1749-6632.2003.tb03214.x

10.1263/jbb.106.74

2012, Arthritis Research & Therapy, 14

2012, Matrix Biology, 31, 290, 10.1016/j.matbio.2012.03.004

1996, Mechanisms of Ageing and Development, 87, 165, 10.1016/0047-6374(96)01703-4

10.1002/art.10650

1996, Osteoarthritis and Cartilage, 4, 263, 10.1016/S1063-4584(05)80104-9

10.1161/CIRCRESAHA.110.234328

10.1002/term.358

10.1111/j.1756-185X.2011.01627.x

10.1016/S0945-053X(01)00136-6

10.1016/S0945-053X(01)00148-2

10.1172/JCI200214386

10.1016/j.matbio.2004.09.005

10.1369/jhc.5C6834.2005

2008, Current Drug Targets, 9, 869, 10.2174/138945008785909293

10.2353/ajpath.2009.090184

2008, Cell Transplantation, 17, 1181, 10.3727/096368908787236648

10.1016/j.actbio.2005.02.001

10.1016/j.jbiomech.2004.04.012

10.1115/1.2978991

10.1115/1.4000938

10.1016/S0945-053X(99)00029-3

10.1002/art.23120

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BioMed Research International

Tập 2014

1-8

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