The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

Cell Host & Microbe - Tập 17 Số 2 - Trang 260-273 - 2015
Aleksandar D. Kostic1,2,3, Dirk Gevers1, Heli Siljander4,5, Tommi Vatanen1,6, Tuulia Hyötyläinen7,8, Anu‐Maaria Hämäläinen9, Aleksandr Peet10, Vallo Tillmann10, Päivi Pöhö11,8, Ismo Mattila7,8, Harri Lähdesmäki6, Eric A. Franzosa3, Outi Vaarala5, Marcus C. de Goffau12, Hermie J. M. Harmsen12, Jorma Ilonen13,14, Suvi Μ. Virtanen15,16,17, Clary B. Clish1, Matej Orešič7,8, Curtis Huttenhower1,3, Mikael Knip4,18,19,5, Ramnik J. Xavier1,2,20,21
1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
2Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
3Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
4Children’s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland
5Research Program Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland
6Department of Information and Computer Science, Aalto University School of Science, 02150 Espoo, Finland
7Steno Diabetes Center, 2820 Gentofte, Denmark
8VTT Technical Research Centre of Finland, 02044 Espoo, Finland
9Department of Pediatrics, Jorvi Hospital, 02740 Espoo, Finland
10Department of Pediatrics, University of Tartu, Estonia and Tartu University Hospital, 51014 Tartu, Estonia
11Faculty of Pharmacy, University of Helsinki, 00290 Helsinki, Finland
12Department of Medical Microbiology, University Medical Center Groningen and University of Groningen, 9713 GZ Groningen, the Netherlands
13Department of Clinical Microbiology, University of Eastern Finland, 70211 Kuopio, Finland
14Immunogenetics Laboratory, University of Turku, 20520 Turku, Finland
15Department of Lifestyle and Participation, National Institute for Health and Welfare, 00271 Helsinki, Finland
16School of Health Sciences, University of Tampere, 33014, Tampere, Finland
17Science Centre, Pirkanmaa Hospital District, 33521 Tampere, Finland
18Department of Pediatrics, Tampere University Hospital, 33521 Tampere, Finland
19Folkhälsan Research Center, 00290 Helsinki, Finland
20Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
21Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

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