The Dioscorea genus: a review of bioactive steroid saponins

Lacaille-Dubois M-A, Wagner H (2000) Bioactive saponins from plants: an update. In: Atta-Ur-Rahman (ed) Studies in natural products chemistry, vol 21. Elsevier Science, Amsterdam, The Netherlands, pp 633–687

Lacaille-Dubois M-A (2005) Bioactive saponins with cancer related and immunomodulatory activity: recent developments. In: Atta-Ur-Rahman (ed) Studies in natural products chemistry, vol 32. Elsevier Science, Amsterdam, The Netherlands, pp 209–246

Lacaille-Dubois M-A (2002) A propos des Dioscorea (le “yam”). La Phytothérapie Européenne 7:9–16

Yang CR, Zhang Y, Jacob MR, Khan SI, Zhang YJ, Li XC (2006) Antifungal activity of C-27 steroidal saponins. Antimicrob Agents Chemother 50(5):1710–1714

Teponno RB, Tapondjou AL, Djoukeng JD, Abou-Mansour E, Tabacci R, Tane P, Lontsi D, Park H-J (2006) Isolation and NMR assignment of a pennogenin glycoside from Dioscorea bulbifera L. var sativa. Nat Prod Sci 12(1):62–66

Sautour M, Mitaine-Offer A-C, Miyamoto T, Dongmo A, Lacaille-Dubois M-A (2004) Antifungal steroid saponins from Dioscorea cayenensis. Planta Med 70(1):90–92

Sautour M, Mitaine-Offer A-C, Miyamoto T, Dongmo A, Lacaille-Dubois M-A (2004) A new steroidal saponin from Dioscorea cayenensis. Chem Pharm Bull (Tokyo) 52(11):1353–1355

Hu K, Yao X (2003) The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro. Phytother Res 17(6):620–626

Hu K, Yao X (2001) Methyl protogracillin (NSC-698792): the spectrum of cytotoxicity against 60 human cancer cell lines in the National Cancer Institute’s anticancer drug screen panel. Anticancer Drugs 12(6):541–547

Hu K, Yao X (2002) Protodioscin (NSC-698 796): Its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med 68(4):297–301

Hu K, Yao X (2002) The cytotoxicity of protoneodioscin (NSC-698789), a furostanol saponin from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro. Phytomedicine 9(6):560–565

Hu K., Yao X (2003) The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest 21(3):389–393

Hu K, Yao XS (2002) The cytotoxicity of methyl protoneodioscin (NSC-698791) against human cancer cell lines in vitro. Anticancer Res 22(2A):1001–1005

Shen P, Wang SL, Liu XK, Yang CR, Cai B, Yao XS (2002) A new steroidal saponin from Dioscorea deltoidea Wall var. orbiculata. Chin Chem Lett 13(9):851–854

Liu HW, Wang SL, Cai B, Qu GX, Yang XJ, Kobayashi H, Yao XS (2003) New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth. J Asian Nat Prod Res 5(4):241–247

Liu HW, Xiong Z, Li F, Qu GX, Kobayashi H, Yao XS (2003) Two new pregnane glycosides from Dioscorea futschauensis R. Kunth. Chem Pharm Bull (Tokyo) 51(9):1089–1091

Liu HW, Zhao QC, Cui CB, Kobayashi H, Yao XS (2002) Bioactive saponins from Dioscorea futschauensis. Pharmazie 57(8):570–572

Liu HW, Kobayashi H, Qu GX, Yao XS (2001) A new spirostanol saponin from Dioscorea futschauensis. Chin Chem Lett 12(7):613–616

Liu HW, Qu GX, Yao XS (2002) A new furostanol saponin from Dioscorea futschauensis. Chin Chem Lett 13(3):241–244

Wang SL, Cai B, Cui CB, Liu HW, Wu CF, Yao XS (2004) Diosgenin-3-O-α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway. J Asian Nat Prod Res 6(2):115–125

Cui CB, Xu C, Gu QQ, Chu SD, Ji HH, Jing G (2004) A new furostanol saponin from the water-extract of Dioscorea nipponica Mak., the raw material of the traditional Chinese herbal medicine Wei Ao Xin. Chin Chem Lett 15(10):1191–1194

Dong M, Feng XZ, Wang BX, Ikejima T, Wu LJ (2004) Steroidal saponins from Dioscorea panthaica and their cytotoxic activity. Pharmazie 59(4):294–296

Dong M, Feng XZ, Wu LJ, Wang BX, Ikejima T (2001) Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity. Planta Med 67(9):853–857

Dong M, Feng XZ, Wang BX, Wu LJ, Ikejima T (2001) Two novel furostanol saponins from the rhizomes of Dioscorea panthaica Prain et Burkill and their cytotoxic activity. Tetrahedron 57(3):501–506

Yang S, Ma Y, Liu XK (2005) Steroidal constituents from Dioscorea parviflora (in Chinese). Yao Xue Xue Bao 40(2):145–149

Osorio JN, Mosquera Martinez OM, Correa Navarro YN, Mimaki Y, Sakagami H, Sashida Y (2003) Diospolysaponin A, a new polyoxygenated spirostanol saponin from the tubers of Dioscorea polygonoides. Heterocycles 60(7):1709–1715

Osorio JN, Mosquera Martinez OM, Correa Navarro YN, Watanabe K, Sakagami H, Mimaki Y (2005) Polyhydroxylated spirostanol saponins from the tubers of Dioscorea polygonoides. J Nat Prod 68(7):1116–1120

Yang DJ, Lu TJ, Hwang LS (2003) Isolation and identification of steroidal saponins in Taiwanese Yam cultivar (Dioscorea pseudojaponica Yamamoto). J Agric Food Chem 51(22):6438–6444

Yin J, Kouda K, Tezuka Y, Tran QL, Miyahara T, Chen Y, Kadota S (2003) Steroidal glycosides from the rhizomes of Dioscorea spongiosa. J Nat Prod 66(5):646–650

Sautour M, Miyamoto T, Lacaille-Dubois M-A (2006) Steroidal saponins and flavan-3-ol glycosides from Dioscorea villosa. Biochem Syst Ecol 34(1):60–63

Sun W, Tu G, Zhang Y (2003) A new steroidal saponin from Dioscorea zingiberensis Wright. Nat Prod Res 17(4):287–292

Agrawal PK (2003) Spectral assignments and reference data. 25R/25S stereochemistry of spirostane-type steroidal sapogenins and steroidal saponins via chemical shift of geminal protons of ring-F. Magn Reson Chem 41(11):965–968

Agrawal PK (2005) Assigning stereodiversity of the 27-Me group of furostane-type steroidal saponins via NMR chemical shifts. Steroids 70(10):715–724

Li R, Zhou Y, Wu Z, Ding L (2006) ESI-QqTOF-MS/MS and APCI-IT-MS/MS analysis of steroid saponins from the rhizomes of Dioscorea panthaica. J Mass Spectrom 41(1):1–22

Tewtrakul S, Itharat A (2006) Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea. J Ethnopharmacol (in press)

Tewtrakul S, Itharat A (2006) Anti-allergic substances from the rhizomes of Dioscorea membranacea. Bioorg Med Chem 14(24):8707–8711

Itharat A, Houghton PJ, Eno-Amooquaye E, Burke PJ, Sampson JH, Raman A (2004) In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. J Ethnopharmacol 90(1):33–38

Quiroga EN, Sampietro AR, Vattuone MA (2001) Screening antifungal activities of selected medicinal plants. J Ethnopharmacol 74(1):89–96

Takechi M, Tanaka Y (1991) Structure–activity relationships of synthetic diosgenyl monoglycosides. Phytochemistry 30(8):2557–2558