The Crystal Structure of Wild-Type Growth Hormone at 2.5 a Resolution

Protein and Peptide Letters - Tập 2 Số 2 - Trang 333-340 - 1995
L. Chantalat1, N.D. Jones2, Fritjof C. F. Körber1, Jorge Navaza3, A.G. Pavlovsky4
1Biophysics Department, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
2Molecular Structure Corporation, 3200 Research Forest Drive, The Woodlands, TX 77381, USA
3UPR 180 CNRS, Lab. de Physique, Faculle de Phannacie, 92290 Chatenay Malabry, France
4Parke-Davis Phannaceuticals, ABL Basic Research Program, PO Box B, Bldg. 539, Frederick MD 21702, USA

Tóm tắt

Abstract: The three-dimensional structure of uncomplexed natural sequence recombinant human growth hormone has been determined to 2.5 A. resolution by means of X-ray crystallographic techniques. The structure was solved using molecular replacement with a model of a hGH variant. The crystallographic refinement of the structure gave a final R-factor of 21.3% for data in the range from 8 to 2.5 A.

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Protein and Peptide Letters

Tập 2 Số 2

333-340

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