The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer
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Ahern TP, Pedersen L, Tarp M, Cronin-Fenton DP, Garne JP, Silliman RA, Sorensen HT, Lash TL (2011) Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study. J Natl Cancer Inst 103(19):1461–1468. doi:10.1093/jnci/djr291
Alikhani N, Ferguson RD, Novosyadlyy R, Gallagher EJ, Scheinman EJ, Yakar S, LeRoith D (2013) Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. Oncogene 32(8):961–967. doi:10.1038/onc.2012.113
Allott EH, Howard LE, Cooperberg MR, Kane CJ, Aronson WJ, Terris MK, Amling CL, Freedland SJ (2014) Serum lipid profile and risk of prostate cancer recurrence: results from the SEARCH database. Cancer Epidemiol Biomarkers Prev 23(11):2349–2356. doi:10.1158/1055-9965.EPI-14-0458
Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H et al (2002) Transcriptional activities of nuclear SREBP-1a, −1c, and −2 to different target promoters of lipogenic and cholesterogenic genes. J Lipid Res 43(8):1220–1235
Anderson GL, Manson J, Wallace R, Lund B, Hall D, Davis S, Shumaker S, Wang CY, Stein E, Prentice RL (2003) Implementation of the Women’s Health Initiative study design. Ann Epidemiol 13(9 Suppl):S5–S17
Bahl M, Ennis M, Tannock IF, Hux JE, Pritchard KI, Koo J, Goodwin PJ (2005) Serum lipids and outcome of early-stage breast cancer: results of a prospective cohort study. Breast Cancer Res Treat 94(2):135–144. doi:10.1007/s10549-005-6654-9
Beck P, Wysowski DK, Downey W, Butler-Jones D (2003) Statin use and the risk of breast cancer. J Clin Epidemiol 56(3):280–285
Bennett MK, Seo YK, Datta S, Shin DJ, Osborne TF (2008) Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J Biol Chem 283(23):15628–15637. doi:10.1074/jbc.M800391200
Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R et al (2008) LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134(1):97–111. doi:10.1016/j.cell.2008.04.052
Berrino F, Villarini A, Traina A, Bonanni B, Panico S, Mano MP, Mercandino A et al (2014) Metabolic syndrome and breast cancer prognosis. Breast Cancer Res Treat 147(1):159–165. doi:10.1007/s10549-014-3076-6
Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW (2007) Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S), 25-epoxycholesterol. J Biol Chem 282(8):5207–5216. doi:10.1074/jbc.M611063200
Bianchini F, Kaaks R, Vainio H (2002) Overweight, obesity, and cancer risk. Lancet Oncol 3(9):565–574
Bjarnadottir O, Romero Q, Bendahl PO, Jirstrom K, Ryden L, Loman N, Uhlen M et al (2013) Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. Breast Cancer Res Treat 138(2):499–508. doi:10.1007/s10549-013-2473-6
Blais L, Desgagne A, LeLorier J (2000) 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and the risk of cancer: a nested case-control study. Arch Intern Med 160(15):2363–2368
Boudreau DM, Gardner JS, Malone KE, Heckbert SR, Blough DK, Daling JR (2004) The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: a case-control study. Cancer 100(11):2308–2316. doi:10.1002/cncr.20271
Brown MS, Dana SE, Goldstein JL (1973) Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proc Natl Acad Sci U S A 70(7):2162–2166
Campbell MJ, Esserman LJ, Zhou Y, Shoemaker M, Lobo M, Borman E, Baehner F et al (2006) Breast cancer growth prevention by statins. Cancer Res 66(17):8707–8714. doi:10.1158/0008-5472.CAN-05-4061
Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61–70. doi:10.1038/nature11412
Capasso I, Esposito E, Pentimalli F, Crispo A, Montella M, Grimaldi M, De Marco M et al (2011) Metabolic syndrome affects breast cancer risk in postmenopausal women: National Cancer Institute of Naples experience. Cancer Biol Ther 10(12):1240–1243
Cauley JA, McTiernan A, Rodabough RJ, LaCroix A, Bauer DC, Margolis KL, Paskett ED et al (2006) Statin use and breast cancer: prospective results from the Women’s Health Initiative. J Natl Cancer Inst 98(10):700–707. doi:10.1093/jnci/djj188
Cauley JA, Zmuda JM, Lui LY, Hillier TA, Ness RB, Stone KL, Cummings SR, Bauer DC (2003) Lipid-lowering drug use and breast cancer in older women: a prospective study. J Womens Health (Larchmt) 12(8):749–756. doi:10.1089/154099903322447710
Centers fo Disease Control and Prevention (2010) Prevalence of abnormal lipid levels among youths—United States, 1999–2006. MMWR 59(2):29–33
Chen Q, Zhang XH, Massague J (2011) Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20(4):538–549. doi:10.1016/j.ccr.2011.08.025
Chittezhath M, Dhillon MK, Lim JY, Laoui D, Shalova IN, Teo YL, Chen J et al (2014) Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression. Immunity 41(5):815–829. doi:10.1016/j.immuni.2014.09.014
Colditz GA, Rosner B (2000) Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses’ Health Study. Am J Epidemiol 152(10):950–964
Collaborative Group on Hormonal Factors in Breast, Cancer (2012) Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol 13(11):1141–1151. doi:10.1016/S1470-2045(12)70425-4
Danilo C, Frank PG (2012) Cholesterol and breast cancer development. Curr Opin Pharmacol 12(6):677–682. doi:10.1016/j.coph.2012.07.009
Das A, Brown MS, Anderson DD, Goldstein JL, Radhakrishnan A (2014) Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife (Cambridge) e02882. doi:10.7554/eLife.02882.
Desai P, Chlebowski R, Cauley JA, Manson JE, Wu C, Martin LW, Jay A et al (2013) Prospective analysis of association between statin use and breast cancer risk in the women’s health initiative. Cancer Epidemiol Biomarkers Prev 22(10):1868–1876. doi:10.1158/1055-9965.EPI-13-0562
(1998) Design of the Women’s Health Initiative clinical trial and observational study. The Women’s Health Initiative Study Group. Control Clin Trials 19(1):61–109.
Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother 58(1):49–59. doi:10.1007/s00262-008-0523-4
DuSell CD, Nelson ER, Wang X, Abdo J, Modder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP (2010) The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology 151(8):3675–3685. doi:10.1210/en.2010-0080
DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol 22(1):65–77. doi:10.1210/me.2007-0383
Endogenous, Hormones, Group Breast Cancer Collaborative, Key TJ, Appleby PN, Reeves GK, Travis RC, Alberg AJ et al (2013) Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies. Lancet Oncol 14(10):1009–1019. doi:10.1016/S1470-2045(13)70301-2
Ewertz M, Jensen MB, Gunnarsdottir KA, Hojris I, Jakobsen EH, Nielsen D, Stenbygaard LE, Tange UB, Cold S (2011) Effect of obesity on prognosis after early-stage breast cancer. J Clin Oncol 29(1):25–31. doi:10.1200/JCO.2010.29.7614
Fessler MB (2015) Regulation of adaptive immunity in health and disease by cholesterol metabolism. Curr Allergy Asthma Rep 15(8):48. doi:10.1007/s11882-015-0548-7
Flaveny CA, Griffett K, El-Gendy Bel D, Kazantzis M, Sengupta M, Amelio AL, Chatterjee A et al (2015) Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell 28(1):42–56. doi:10.1016/j.ccell.2015.05.007
Friis S, Poulsen AH, Johnsen SP, McLaughlin JK, Fryzek JP, Dalton SO, Sorensen HT, Olsen JH (2005) Cancer risk among statin users: a population-based cohort study. Int J Cancer 114(4):643–647. doi:10.1002/ijc.20758
Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP, Lund EG (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem 276(42):38378–38387. doi:10.1074/jbc.M105805200
Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9(3):162–174. doi:10.1038/nri2506
Goldstein JL, Brown MS (1973) Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc Natl Acad Sci U S A 70(10):2804–2808
Gostynski M, Gutzwiller F, Kuulasmaa K, Doring A, Ferrario M, Grafnetter D, Pajak A, Who Monica Project (2004) Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA Project. Int J Obes Relat Metab Disord 28(8):1082–1090. doi:10.1038/sj.ijo.0802714
Graaf MR, Beiderbeck AB, Egberts AC, Richel DJ, Guchelaar HJ (2004) The risk of cancer in users of statins. J Clin Oncol 22(12):2388–2394. doi:10.1200/JCO.2004.02.027
Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883–899. doi:10.1016/j.cell.2010.01.025
Ha M, Sung J, Song YM (2009) Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women. Cancer Causes Control 20(7):1055–1060. doi:10.1007/s10552-009-9301-7
Haile LA, Gamrekelashvili J, Manns MP, Korangy F, Greten TF (2010) CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice. J Immunol 185(1):203–210. doi:10.4049/jimmunol.0903573
Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, King MC (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250(4988):1684–1689
Hong C, Tontonoz P (2014) Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov 13(6):433–444. doi:10.1038/nrd4280
Hu J, La Vecchia C, de Groh M, Negri E, Morrison H, Mery L, Group Canadian Cancer Registries Epidemiology Research (2012) Dietary cholesterol intake and cancer. Ann Oncol 23(2):491–500. doi:10.1093/annonc/mdr155
Hua X, Nohturfft A, Goldstein JL, Brown MS (1996) Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 87(3):415–426
Huang SH, Waldron JN, Milosevic M, Shen X, Ringash J, Su J, Tong L et al (2015) Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status. Cancer 121(4):545–555. doi:10.1002/cncr.29100
Jiralerspong S, Kim ES, Dong W, Feng L, Hortobagyi GN, Giordano SH (2013) Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients. Ann Oncol 24(10):2506–2514. doi:10.1093/annonc/mdt224
Jones LW, Alfano CM (2013) Exercise-oncology research: past, present, and future. Acta Oncol 52(2):195–215. doi:10.3109/0284186X.2012.742564
Karuna R, Holleboom AG, Motazacker MM, Kuivenhoven JA, Frikke-Schmidt R, Tybjaerg-Hansen A, Georgopoulos S et al (2011) Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. Atherosclerosis 214(2):448–455. doi:10.1016/j.atherosclerosis.2010.10.042
Kaye JA, Jick H (2004) Statin use and cancer risk in the General Practice Research Database. Br J Cancer 90(3):635–637. doi:10.1038/sj.bjc.6601566
Kitahara CM, Berrington de Gonzalez A, Freedman ND, Huxley R, Mok Y, Jee SH, Samet JM (2011) Total cholesterol and cancer risk in a large prospective study in Korea. J Clin Oncol 29(12):1592–1598. doi:10.1200/JCO.2010.31.5200
Kwan ML, Habel LA, Flick ED, Quesenberry CP, Caan B (2008) Post-diagnosis statin use and breast cancer recurrence in a prospective cohort study of early stage breast cancer survivors. Breast Cancer Res Treat 109(3):573–579. doi:10.1007/s10549-007-9683-8
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P (2001) LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A 98(2):507–512. doi:10.1073/pnas.021488798
Lappano R, Recchia AG, De Francesco EM, Angelone T, Cerra MC, Picard D, Maggiolini M (2011) The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor alpha-mediated signaling in cancer cells and in cardiomyocytes. PLoS One 6(1):e16631. doi:10.1371/journal.pone.0016631
Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, Park E et al (2008) Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res 68(24):10238–10246. doi:10.1158/0008-5472.CAN-08-2755
Lee JH, Gong H, Khadem S, Lu Y, Gao X, Li S, Zhang J, Xie W (2008) Androgen deprivation by activating the liver X receptor. Endocrinology 149(8):3778–3788. doi:10.1210/en.2007-1605
Liu J, Xu A, Lam KS, Wong NS, Chen J, Shepherd PR, Wang Y (2013) Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. Oncotarget 4(10):1804–1818
Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, Sotgia F, Lisanti MP, Frank PG (2011) Role of cholesterol in the development and progression of breast cancer. Am J Pathol 178(1):402–412. doi:10.1016/j.ajpath.2010.11.005
Lo Sasso G, Murzilli S, Salvatore L, D’Errico I, Petruzzelli M, Conca P, Jiang ZY, Calabresi L, Parini P, Moschetta A (2010) Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell Metab 12(2):187–193. doi:10.1016/j.cmet.2010.07.002
Lord SJ, Bernstein L, Johnson KA, Malone KE, McDonald JA, Marchbanks PA, Simon MS et al (2008) Breast cancer risk and hormone receptor status in older women by parity, age of first birth, and breastfeeding: a case-control study. Cancer Epidemiol Biomarkers Prev 17(7):1723–1730. doi:10.1158/1055-9965.EPI-07-2824
Luo Y, Zhou H, Krueger J, Kaplan C, Lee SH, Dolman C, Markowitz D et al (2006) Targeting tumor-associated macrophages as a novel strategy against breast cancer. J Clin Invest 116(8):2132–2141. doi:10.1172/JCI27648
Mafuvadze B, Liang Y, Hyder SM (2014) Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor. Oncol Rep 32(4):1727–1733. doi:10.3892/or.2014.3332
Martinez-Outschoorn UE, Sotgia F, Lisanti MP (2015) Caveolae and signalling in cancer. Nat Rev Cancer 15(4):225–237. doi:10.1038/nrc3915
McPherson K, Steel CM, Dixon JM (2000) ABC of breast diseases. Breast cancer—epidemiology, risk factors, and genetics. BMJ 321(7261):624–628
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK et al (2013) Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 45(4):353–361. doi:10.1038/ng.2563, 361e351-352
Michels KB, Solomon CG, Hu FB, Rosner BA, Hankinson SE, Colditz GA, Manson JE, Study Nurses’ Health (2003) Type 2 diabetes and subsequent incidence of breast cancer in the Nurses’ Health Study. Diabetes Care 26(6):1752–1758
Mundal L, Sarancic M, Ose L, Iversen PO, Borgan JK, Veierod MB, Leren TP, Retterstol K (2014) Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. J Am Heart Assoc 3(6):e001236. doi:10.1161/JAHA.114.001236
Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH (1999) The disease burden associated with overweight and obesity. JAMA 282(16):1523–1529
Nelson ER, Chang CY, McDonnell DP (2014) Cholesterol and breast cancer pathophysiology. Trends Endocrinol Metab 25(12):649–655. doi:10.1016/j.tem.2014.10.001
Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M et al (2011) The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology 152(12):4691–4705. doi:10.1210/en.2011-1298
Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ et al (2013) 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 342(6162):1094–1098. doi:10.1126/science.1241908
Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM (2015) Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the Women’s Health Initiative randomized clinical trials. JAMA Oncol. doi:10.1001/jamaoncol.2015.1546
Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM et al (2015) Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the Women’s Health Initiative randomized clinical trials. JAMA Onco 1(5):611–621. doi:10.1001/jamaoncol.2015.1546
Nguyen-Vu T, Vedin LL, Liu K, Jonsson P, Lin JZ, Candelaria NR, Candelaria LP et al (2013) Liver X receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism. Breast Cancer Res 15(3):R51. doi:10.1186/bcr3443
Nguyen VT, Barozzi I, Faronato M, Lombardo Y, Steel JH, Patel N, Darbre P et al (2015) Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nat Commun 6:10044. doi:10.1038/ncomms10044
Nielsen SF, Nordestgaard BG, Bojesen SE (2012) Statin use and reduced cancer-related mortality. N Engl J Med 367(19):1792–1802. doi:10.1056/NEJMoa1201735
Ogden CL, Carroll MD, Kit BK, Flegal KM (2014) Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311(8):806–814. doi:10.1001/jama.2014.732
Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS (2001) Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci U S A 98(11):6027–6032. doi:10.1073/pnas.111138698
Pasanisi P, Berrino F, De Petris M, Venturelli E, Mastroianni A, Panico S (2006) Metabolic syndrome as a prognostic factor for breast cancer recurrences. Int J Cancer 119(1):236–238. doi:10.1002/ijc.21812
Pelton K, Coticchia CM, Curatolo AS, Schaffner CP, Zurakowski D, Solomon KR, Moses MA (2014) Hypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo. Am J Pathol 184(7):2099–2110. doi:10.1016/j.ajpath.2014.03.006
Pencheva N, Buss CG, Posada J, Merghoub T, Tavazoie SF (2014) Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation. Cell 156(5):986–1001. doi:10.1016/j.cell.2014.01.038
Petracci E, Decarli A, Schairer C, Pfeiffer RM, Pee D, Masala G, Palli D, Gail MH (2011) Risk factor modification and projections of absolute breast cancer risk. J Natl Cancer Inst 103(13):1037–1048. doi:10.1093/jnci/djr172
Pierobon M, Frankenfeld CL (2013) Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res Treat 137(1):307–314. doi:10.1007/s10549-012-2339-3
Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G et al (2010) Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene 29(18):2712–2723. doi:10.1038/onc.2010.30
Qian BZ, Pollard JW (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141(1):39–51. doi:10.1016/j.cell.2010.03.014
Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A et al (2013) The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J Exp Med 210(9):1711–1728. doi:10.1084/jem.20130440
Renehan AG, Roberts DL, Dive C (2008) Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 114(1):71–83. doi:10.1080/13813450801954303
Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F et al (2014) Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 25(6):846–859. doi:10.1016/j.ccr.2014.05.016
Ronco AL, De Stefani E, Stoll M (2010) Hormonal and metabolic modulation through nutrition: towards a primary prevention of breast cancer. Breast 19(5):322–332. doi:10.1016/j.breast.2010.05.005
Sag D, Cekic C, Wu R, Linden J, Hedrick CC (2015) The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun 6:6354. doi:10.1038/ncomms7354
Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S et al (2000) Role of LXRs in control of lipogenesis. Genes Dev 14(22):2831–2838
Shah R, Rosso K, Nathanson SD (2014) Pathogenesis, prevention, diagnosis and treatment of breast cancer. World J Clin Oncol 5(3):283–298. doi:10.5306/wjco.v5.i3.283
Shen M, Hu P, Donskov F, Wang G, Liu Q, Du J (2014) Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. PLoS One 9(6):e98259. doi:10.1371/journal.pone.0098259
Siegel RL, Miller KD, Jemal A (2015) Cancer statistics, 2015. CA Cancer J Clin 65(1):5–29. doi:10.3322/caac.21254
Singletary SE (2003) Rating the risk factors for breast cancer. Ann Surg 237(4):474–482. doi:10.1097/01.SLA.0000059969.64262.87
Solito S, Falisi E, Diaz-Montero CM, Doni A, Pinton L, Rosato A, Francescato S et al (2011) A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood 118(8):2254–2265. doi:10.1182/blood-2010-12-325753
Spann NJ, Glass CK (2013) Sterols and oxysterols in immune cell function. Nat Immunol 14(9):893–900. doi:10.1038/ni.2681
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ et al (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 11(2):155–161. doi:10.1038/ni.1836
Strachan DC, Ruffell B, Oei Y, Bissell MJ, Coussens LM, Pryer N, Daniel D (2013) CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells. Oncoimmunology 2(12):e26968. doi:10.4161/onci.26968
Sullivan PM, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick RL, Quarfordt SH, Maeda N (1997) Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 272(29):17972–17980
Thelen KM, Lutjohann D, Vesalainen R, Janatuinen T, Knuuti J, von Bergmann K, Lehtimaki T, Laaksonen R (2006) Effect of pravastatin on plasma sterols and oxysterols in men. Eur J Clin Pharmacol 62(1):9–14. doi:10.1007/s00228-005-0068-9
Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ (2007) 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med 13(10):1185–1192. doi:10.1038/nm1641
Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, Shaul PW (2014) The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab 20(1):172–182. doi:10.1016/j.cmet.2014.05.013
Undela K, Srikanth V, Bansal D (2012) Statin use and risk of breast cancer: a meta-analysis of observational studies. Breast Cancer Res Treat 135(1):261–269. doi:10.1007/s10549-012-2154-x
Vedin LL, Lewandowski SA, Parini P, Gustafsson JA, Steffensen KR (2009) The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis 30(4):575–579. doi:10.1093/carcin/bgp029
Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F et al (2010) Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med 16(1):98–105. doi:10.1038/nm.2074
Wang X, Simpson ER, Brown KA (2015) Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer. J Steroid Biochem Mol Biol 153:35–44. doi:10.1016/j.jsbmb.2015.07.008
Waxler SH, Tabar P, Melcher LR (1953) Obesity and the time of appearance of spontaneous mammary carcinoma in C3H mice. Cancer Res 13(3):276–278
White CP (1909) On the occurrence of crystals in tumours. J Pathol Bacteriol 13(1):3–10. doi:10.1002/path.1700130103
Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B et al (2013) 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep 5(3):637–645. doi:10.1016/j.celrep.2013.10.006
Xuan QJ, Wang JX, Nanding A, Wang ZP, Liu H, Lian X, Zhang QY (2014) Tumor-associated macrophages are correlated with tamoxifen resistance in the postmenopausal breast cancer patients. Pathol Oncol Res 20(3):619–624. doi:10.1007/s12253-013-9740-z
Youn JI, Nagaraj S, Collazo M, Gabrilovich DI (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 181(8):5791–5802
Zelcer N, Hong C, Boyadjian R, Tontonoz P (2009) LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325(5936):100–104. doi:10.1126/science.1168974
Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C et al (2008) Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest 118(6):2281–2290. doi:10.1172/JCI32561
Zhang L, Reue K, Fong LG, Young SG, Tontonoz P (2012) Feedback regulation of cholesterol uptake by the LXR–IDOL–LDLR axis. Arterioscler Thromb Vasc Biol 32(11):2541–2546. doi:10.1161/ATVBAHA.112.250571
Zhang QW, Liu L, Gong CY, Shi HS, Zeng YH, Wang XZ, Zhao YW, Wei YQ (2012) Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One 7(12):e50946. doi:10.1371/journal.pone.0050946