The Coagulopathy of Trauma: A Review of Mechanisms

Krug, 2000, The global burden of injuries., Am J Public Health, 90, 523, 10.2105/AJPH.90.4.523

Sauaia, 1995, Epidemiology of trauma deaths: a reassessment., J Trauma, 38, 185, 10.1097/00005373-199502000-00006

Schreiber, 2004, Damage control surgery., Crit Care Clin, 20, 101, 10.1016/S0749-0704(03)00095-2

Sauaia, 1994, Early predictors of postinjury multiple organ failure., Arch Surg, 129, 39, 10.1001/archsurg.1994.01420250051006

Esmon, 2005, The interactions between inflammation and coagulation., Br J Haematol, 131, 417, 10.1111/j.1365-2141.2005.05753.x

Charles, 2007, Blood transfusion is an independent predictor of mortality after blunt trauma., Am Surg, 73, 1, 10.1177/000313480707300101

Dunne, 2004, Allogenic blood transfusion in the first 24 hours after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death., Surg Infect (Larchmt), 5, 395, 10.1089/sur.2004.5.395

Silverboard, 2005, The role of acute blood transfusion in the development of acute respiratory distress syndrome in patients with severe trauma., J Trauma, 59, 717

Murray, 2007, Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study., J Neurotrauma, 24, 329, 10.1089/neu.2006.0035

Stein, 2002, Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury., J Neurosurg, 97, 1373, 10.3171/jns.2002.97.6.1373

Brohi, 2003, Acute traumatic coagulopathy., J Trauma, 54, 1127, 10.1097/01.TA.0000069184.82147.06

MacLeod, 2003, Early coagulopathy predicts mortality in trauma., J Trauma, 55, 39, 10.1097/01.TA.0000075338.21177.EF

Maegele, 2007, Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients., Injury, 38, 298, 10.1016/j.injury.2006.10.003

Rugeri, 2007, Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography., J Thromb Haemost, 5, 289, 10.1111/j.1538-7836.2007.02319.x

Roberts, 2006, A cell-based model of thrombin generation., Semin Thromb Hemost, 32, 32, 10.1055/s-2006-939552

Verhamme, 2006, The pivotal role of the endothelium in haemostasis and thrombosis., Acta Clin Belg, 61, 213, 10.1179/acb.2006.036

Borgman, 2007, The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital., J Trauma, 63, 805

Brohi, 2007, Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?, Ann Surg, 245, 812, 10.1097/01.sla.0000256862.79374.31

Mann, 1999, Biochemistry and physiology of blood coagulation., Thromb Haemost, 82, 165, 10.1055/s-0037-1615780

Lau, 2003, The interaction between platelets and factor VII/VIIa., Transfus Apher Sci, 28, 279, 10.1016/S1473-0502(03)00047-8

Hrafnkelsdottir, 2001, Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man., Thromb Haemost, 85, 875, 10.1055/s-0037-1615762

Di Cera, 2003, Thrombin interactions., Chest, 124, 11S, 10.1378/chest.124.3_suppl.11S

Sinisalo, 1999, Endothelial release of tissue-type plasminogen activator and ischemia-induced vasodilatation are linked in patients with coronary heart disease., Blood Coagul Fibrinolysis, 10, 181, 10.1097/00001721-199906000-00004

Osterlund, 2002, Myocardial ischemia induces coronary t-PA release in the pig., Acta Anaesthesiol Scand, 46, 271, 10.1034/j.1399-6576.2002.t01-1-460308.x

Dhall, 1983, Fibrin network structure: modification by platelets., Thromb Haemost, 49, 42, 10.1055/s-0038-1657312

Zehtabchi, 2008, The association of coagulopathy and traumatic brain injury in patients with isolated head injury., Resuscitation, 76, 52, 10.1016/j.resuscitation.2007.06.024

Stein, 2004, Coagulopathy in traumatic brain injury., Neurocrit Care, 1, 479, 10.1385/NCC:1:4:479

Cohen, 2007, Early coagulopathy after traumatic brain injury: the role of phyoperfusion and the protein C pathway., J Trauma, 63, 1254

Kushimoto, 2003, Implications of fibrinogenolysis in patients with closed head injury., J Neurotrauma, 20, 357, 10.1089/089771503765172318

Kunz, 1971, Plasma lipids, coagulation factors and fibrin formation after severe multiple trauma and an adult respiratory distress syndrome., J Trauma, 18, 115, 10.1097/00005373-197802000-00007

Mellor, 2001, Fat embolism., Anaesthesia, 56, 145, 10.1046/j.1365-2044.2001.01724.x

Simmons, 1969, Coagulation disorders in combat casualties. I. Acute changes after wounding. II. Effects of massive transfusion. 3. Post-resuscitative changes., Ann Surg, 169, 455, 10.1097/00000658-196904000-00001

Rezaie, 2001, Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C., J Biol Chem, 276, 15567, 10.1074/jbc.C100123200

Bajzar, 2004, Thrombin activatable fibrinolysis inhibitor: not just an inhibitor of fibrinolysis., Crit Care Med, 32, S320, 10.1097/01.CCM.0000126361.00450.B1

Bajzar, 1996, The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent., Blood, 88, 2093, 10.1182/blood.V88.6.2093.bloodjournal8862093

Brummel-Ziedins, 2006, The resuscitative fluid you choose may potentiate bleeding., J Trauma, 61, 1350, 10.1097/01.ta.0000235525.64176.01

Ho, 2005, Are we giving enough coagulation factors during major trauma resuscitation?, Am J Surg, 190, 479, 10.1016/j.amjsurg.2005.03.034

Hirshberg, 2003, Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation., J Trauma, 54, 454, 10.1097/01.TA.0000053245.08642.1F

Brazil, 2000, Sonoclot coagulation analysis of in-vitro haemodilution with resuscitation solutions., J R Soc Med, 93, 507, 10.1177/014107680009301003

Coats, 2006, Impairment of coagulation by commonly used resuscitation fluids in human volunteers., Emerg Med J, 23, 846, 10.1136/emj.2006.036574

Van der Linden, 2006, The effects of colloid solutions on hemostasis., Can J Anaesth, 53, S30, 10.1007/BF03022250

Boldt, 2003, New light on intravascular volume replacement regimens: what did we learn from the past three years?, Anesth Analg, 97, 1595, 10.1213/01.ANE.0000089961.15975.78

Craig, 1994, Resuscitation in uncontrolled hemorrhage., Am Surg, 60, 59

Armand, 2003, Treating coagulopathy in trauma patients., Transfus Med Rev, 17, 223, 10.1016/S0887-7963(03)00022-1

Ketchum, 2006, Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma., J Trauma, 60, S51

Malone, 2006, Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol., J Trauma, 60, S91

Ho, 2005, A mathematical model for fresh frozen plasma transfusion strategies during major trauma resuscitation with ongoing hemorrhage., Can J Surg, 48, 470

Reed, 1990, Hypothermia and blood coagulation: dissociation between enzyme activity and clotting factor levels., Circ Shock, 32, 141

Wolberg, 2004, A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function., J Trauma, 56, 1221, 10.1097/01.TA.0000064328.97941.FC

Meng, 2003, The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients., J Trauma, 55, 886, 10.1097/01.TA.0000066184.20808.A5

Kermode, 1999, Marked temperature dependence of the platelet calcium signal induced by human von Willebrand factor., Blood, 94, 199, 10.1182/blood.V94.1.199.413k14_199_207

Valeri, 1987, Hypothermia-induced reversible platelet dysfunction., Ann Surg, 205, 175, 10.1097/00000658-198702000-00012

Tsuei, 2004, Hypothermia in the trauma patient., Injury, 35, 7, 10.1016/S0020-1383(03)00309-7

Farkash, 2002, Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?, Injury, 33, 103, 10.1016/S0020-1383(01)00149-8

Shafi, 2005, Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry., J Trauma, 59, 1081, 10.1097/01.ta.0000188647.03665.fd

Siegel, 1990, Early physiologic predictors of injury severity and death in blunt multiple trauma., Arch Surg, 125, 498, 10.1001/archsurg.1990.01410160084019

Rutherford, 1992, Base deficit stratifies mortality and determines therapy., J Trauma, 33, 417, 10.1097/00005373-199209000-00014

Martini, 2007, Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs., Crit Care Med, 35, 1568, 10.1097/01.CCM.0000266682.74602.6A

Engstrom, 2006, Acidosis impairs the coagulation: A thromboelastographic study., J Trauma, 61, 624, 10.1097/01.ta.0000226739.30655.75

Martini, 2006, Does bicarbonate correct coagulation function impaired by acidosis in swine?, J Trauma, 61, 99, 10.1097/01.ta.0000215574.99093.22

Ganter, 2008, Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?, Ann Surg, 247, 320, 10.1097/SLA.0b013e318162d616

Esmon, 2004, Crosstalk between inflammation and thrombosis., Maturitas, 47, 305, 10.1016/j.maturitas.2003.10.015

Landis, 2007, Protease activated receptors: clinical relevance to hemostasis and inflammation., Hematol Oncol Clin North Am, 21, 103, 10.1016/j.hoc.2006.11.005

Huber-Lang, 2006, Generation of C5a in the absence of C3: a new complement activation pathway., Nat Med, 12, 682, 10.1038/nm1419

Ganter, 2007, Role of the alternative pathway in the early complement activation following major trauma., Shock, 28, 29, 10.1097/shk.0b013e3180342439

Tou, 2005, Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils., Cell Signal, 17, 77, 10.1016/j.cellsig.2004.06.003

Yatomi, 2000, Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells., Blood, 96, 3431, 10.1182/blood.V96.10.3431

Levi, 1997, The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia., Eur J Clin Invest, 27, 3, 10.1046/j.1365-2362.1997.570614.x

Seitz, 1989, The disturbance of hemostasis in septic shock: role of neutrophil elastase and thrombin, effects of antithrombin III and plasma substitution., Eur J Haematol, 43, 22, 10.1111/j.1600-0609.1989.tb01246.x

Shebuski, 2002, Role of inflammatory mediators in thrombogenesis., J Pharmacol Exp Ther, 300, 729, 10.1124/jpet.300.3.729

McGilvray, 2002, Monocyte adhesion and transmigration induce tissue factor expression: role of the mitogen-activated protein kinases., Shock, 18, 51, 10.1097/00024382-200207000-00010

Rigby, 2004, Protein S: a conduit between anticoagulation and inflammation., Crit Care Med, 32, S336, 10.1097/01.CCM.0000126360.00450.F8

Esmon, 2002, Protein C pathway in sepsis., Ann Med, 34, 598, 10.1080/078538902321117823

Knudson, 1992, Thromboembolism following multiple trauma., J Trauma, 32, 2, 10.1097/00005373-199201000-00002

Levi, 2007, Disseminated intravascular coagulation., Crit Care Med, 35, 2191, 10.1097/01.CCM.0000281468.94108.4B

Spivey, 2005, Therapeutic approaches in trauma-induced coagulopathy., Minerva Anestesiol, 71, 281

Holcomb, 2007, Damage control resuscitation: directly addressing the early coagulopathy of trauma., J Trauma, 62, 307