The Clinical Approach Toward Giant Cell Tumor of Bone

Athanasou, 2013, WHO Classification of Tumours of Soft Tissue and Bone, 321

Balke, 2008, Giant cell tumor of bone: Treatment and outcome of 214 cases, J Cancer Res Clin Oncol, 134, 969, 10.1007/s00432-008-0370-x

Campanacci, 1987, Giant-cell tumor of bone, J Bone Joint Surg Am, 69, 106, 10.2106/00004623-198769010-00018

Forsyth, 2013, WHO Classification of Tumours of Soft Tissue and Bone, 320

Siebenrock, 1998, Giant-cell tumour of bone metastasising to the lungs. A long-term follow-up, J Bone Joint Surg Br, 80, 43, 10.1302/0301-620X.80B1.0800043

Tubbs, 1992, Benign giant-cell tumor of bone with pulmonary metastases: Clinical findings and radiologic appearance of metastases in 13 cases, AJR Am J Roentgenol, 158, 331, 10.2214/ajr.158.2.1729794

Dominkus, 2006, Histologically verified lung metastases in benign giant cell tumours—14 cases from a single institution, Int Orthop, 30, 499, 10.1007/s00264-006-0204-x

Rock, 1984, Metastases from histologically benign giant-cell tumor of bone, J Bone Joint Surg Am, 66, 269, 10.2106/00004623-198466020-00014

Kay, 1994, Pulmonary metastasis of benign giant cell tumor of bone. Six histologically confirmed cases, including one of spontaneous regression, Clin Orthop Relat Res, 219

Becker, 2008, Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy, J Bone Joint Surg Am, 90, 1060, 10.2106/JBJS.D.02771

Kivioja, 2008, Cement is recommended in intralesional surgery of giant cell tumors: A Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years, Acta Orthop, 79, 86, 10.1080/17453670710014815

Algawahmed, 2010, High-speed burring with and without the use of surgical adjuvants in the intralesional management of giant cell tumor of bone: A systematic review and meta-analysis, Sarcoma, 586090

Errani, 2010, Giant cell tumor of the extremity: A review of 349 cases from a single institution, Cancer Treat Rev, 36, 1, 10.1016/j.ctrv.2009.09.002

Klenke, 2011, Giant cell tumor of bone: Risk factors for recurrence, Clin Orthop Relat Res, 469, 591, 10.1007/s11999-010-1501-7

Van der Heijden, 2012, Soft tissue extension increases the risk of local recurrence after curettage with adjuvants for giant-cell tumor of the long bones, Acta Orthop, 83, 401, 10.3109/17453674.2012.711193

Henderson, 2011, Failure mode classification for tumor endoprostheses: Retrospective review of five institutions and a literature review, J Bone Joint Surg Am, 93, 418, 10.2106/JBJS.J.00834

Jeys, 2006, Impending fractures in giant cell tumours of the distal femur: Incidence and outcome, Int Orthop, 30, 135, 10.1007/s00264-005-0061-z

McDonald, 1986, Giant-cell tumor of bone, J Bone Joint Surg Am, 68, 235, 10.2106/00004623-198668020-00009

Shehadeh, 2010, Late complications and survival of endoprosthetic reconstruction after resection of bone tumors, Clin Orthop Relat Res, 468, 2885, 10.1007/s11999-010-1454-x

Thomas, 2010, Denosumab in patients with giant-cell tumour of bone: An open-label, phase 2 study, Lancet Oncol, 11, 275, 10.1016/S1470-2045(10)70010-3

Branstetter, 2012, Denosumab induces tumor reduction and bone formation in patients with giant-cell tumor of bone, Clin Cancer Res, 18, 4415, 10.1158/1078-0432.CCR-12-0578

Balke, 2010, Bisphosphonate treatment of aggressive primary, recurrent and metastatic giant cell tumour of bone, BMC Cancer, 10, 462, 10.1186/1471-2407-10-462

Chawla, 2013, Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: Interim analysis of an open-label, parallel-group, phase 2 study, Lancet Oncol, 14, 901, 10.1016/S1470-2045(13)70277-8

Van der Woude, 1998, Musculoskeletal tumors: Does fast dynamic contrast-enhanced subtraction MR imaging contribute to the characterization?, Radiology, 208, 821, 10.1148/radiology.208.3.9722866

Verstraete, 1996, Dynamic contrast-enhanced MR imaging of musculoskeletal tumors: Basic principles and clinical applications, J Magn Reson Imaging, 6, 311, 10.1002/jmri.1880060210

Murphey, 2001, From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologic-pathologic correlation, Radiographics, 21, 1283, 10.1148/radiographics.21.5.g01se251283

Chakarun, 2013, Giant cell tumor of bone: Review, mimics, and new developments in treatment, Radiographics, 33, 197, 10.1148/rg.331125089

De Schepper, 2007, Giant cell tumors of the tendon sheath may present radiologically as intrinsic osseous lesions, Eur Radiol, 17, 499, 10.1007/s00330-006-0320-4

Mulder, 1993, Radiologic Atlas of Bone Tumors, 483

Enneking, 1980, A system for the surgical staging of musculoskeletal sarcoma, Clin Orthop Relat Res, 106

Rock, 1990, Curettage of giant cell tumor of bone. Factors influencing local recurrences and metastasis, Chir Organi Mov, 75, 204

Aoki, 1996, MR findings indicative of hemosiderin in giant-cell tumor of bone: Frequency, cause, and diagnostic significance, AJR Am J Roentgenol, 166, 145, 10.2214/ajr.166.1.8571864

Verstraete, 2000, Bone and soft tissue tumors: The role of contrast agents for MR imaging, Eur J Radiol, 34, 229, 10.1016/S0720-048X(00)00202-3

ESMO/European Sarcoma Network Working Group, 2012, Bone sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up, Ann Oncol, 23, vii100

Biermann, 2013, Updates in the treatment of bone cancer, J Natl Compr Canc Netw, 11, 681, 10.6004/jnccn.2013.0200

Alberghini, 2010, Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone, Virchows Arch, 456, 97, 10.1007/s00428-009-0863-2

Hemingway, 2011, RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II, Bone, 48, 938, 10.1016/j.bone.2010.12.023

Hemingway, 2012, Smooth muscle actin expression in primary bone tumours, Virchows Arch, 460, 525, 10.1007/s00428-012-1235-x

Thomas, 2012, RANKL, denosumab, and giant cell tumor of bone, Curr Opin Oncol, 24, 397, 10.1097/CCO.0b013e328354c129

Roux, 2002, RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone, Am J Clin Pathol, 117, 210, 10.1309/BPET-F2PE-P2BD-J3P3

Morgan, 2005, Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB, Am J Pathol, 167, 117, 10.1016/S0002-9440(10)62959-8

Liao, 2005, Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone, J Orthop Res, 23, 203, 10.1016/j.orthres.2004.06.018

Clézardin, 2011, The role of RANK/RANKL/osteoprotegerin (OPG) triad in cancer-induced bone diseases: Physiopathology and clinical implications [in French], Bull Cancer, 98, 837, 10.1684/bdc.2011.1398

Forsyth, 2009, CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone, J Bone Miner Res, 24, 70, 10.1359/jbmr.080905

Maggiani, 2011, The immunophenotype of osteoclasts and macrophage polykaryons, J Clin Pathol, 64, 701, 10.1136/jcp.2011.090852

Balla, 2011, Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone, Histopathology, 59, 376, 10.1111/j.1365-2559.2011.03948.x

Lindeman, 2004, Cathepsin K is the principal protease in giant cell tumor of bone, Am J Pathol, 165, 593, 10.1016/S0002-9440(10)63323-8

Ng, 2010, CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression, J Cell Biochem, 110, 438, 10.1002/jcb.22556

Balke, 2011, A short-term in vivo model for giant cell tumor of bone, BMC Cancer, 11, 241, 10.1186/1471-2407-11-241

Rao, 2005, Molecular analysis of primary and recurrent giant cell tumors of bone, Cancer Genet Cytogenet, 158, 126, 10.1016/j.cancergencyto.2004.09.015

Gorunova, 2009, Cytogenetic analysis of 101 giant cell tumors of bone: Nonrandom patterns of telomeric associations and other structural aberrations, Genes Chromosomes Cancer, 48, 583, 10.1002/gcc.20667

Forsyth, 2008, Telomere biology in giant cell tumour of bone, J Pathol, 214, 555, 10.1002/path.2301

Schwartz, 1993, Telomere reduction in giant cell tumor of bone and with aging, Cancer Genet Cytogenet, 71, 132, 10.1016/0165-4608(93)90018-H

Panagopoulos, 2001, No EWS/FLI1 fusion transcripts in giant-cell tumors of bone, Int J Cancer, 93, 769, 10.1002/ijc.1415

Behjati, 2013, Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone, Nat Genet, 45, 1479, 10.1038/ng.2814

Moskovszky, 2010, Centrosome abnormalities in giant cell tumour of bone: Possible association with chromosomal instability, Mod Pathol, 23, 359, 10.1038/modpathol.2009.134

Moskovszky, 2009, Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis, Genes Chromosomes Cancer, 48, 468, 10.1002/gcc.20656

Antal, 1999, The prognostic significance of DNA cytophotometry and proliferation index (Ki-67) in giant cell tumors of bone, Int Orthop, 23, 315, 10.1007/s002640050381

Oda, 2001, Secondary malignant giant-cell tumour of bone: Molecular abnormalities of p53 and H-ras gene correlated with malignant transformation, Histopathology, 39, 629, 10.1046/j.1365-2559.2001.01275.x

Saito, 2011, A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up, Hum Pathol, 42, 727, 10.1016/j.humpath.2010.08.008

Wang, 2012, Giant cell tumour of bone: A new evaluating system is necessary, Int Orthop, 36, 2521, 10.1007/s00264-012-1664-9

Boons, 2002, Oncologic and functional results after treatment of giant cell tumors of bone, Arch Orthop Trauma Surg, 122, 17, 10.1007/s004020100317

Ghert, 2002, Giant-cell tumor of the appendicular skeleton, Clin Orthop Relat Res, 201

Turcotte, 2002, Giant cell tumor of long bone: A Canadian Sarcoma Group study, Clin Orthop Relat Res, 248

Ward, 2002, Customized treatment algorithm for giant cell tumor of bone: Report of a series, Clin Orthop Relat Res, 259

Su, 2004, Giant-cell tumors of bone: An analysis of 87 cases, Int Orthop, 28, 239, 10.1007/s00264-004-0564-z

Capanna, 1990, Curettage of giant cell tumor of bone. The effect of surgical technique and adjuvants on local recurrence rate, Chir Organi Mov, 75, 206

Dürr, 1999, Phenol as an adjuvant for local control in the treatment of giant cell tumour of the bone, Eur J Surg Oncol, 25, 610, 10.1053/ejso.1999.0716

Trieb, 2001, Recurrence of curetted and bone-grafted giant-cell tumours with and without adjuvant phenol therapy, Eur J Surg Oncol, 27, 200, 10.1053/ejso.2000.1086

Gaston, 2011, Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?, J Bone Joint Surg Br, 93, 1665, 10.1302/0301-620X.93B12.27663

O'Donnell, 1994, Recurrence of giant-cell tumors of the long bones after curettage and packing with cement, J Bone Joint Surg Am, 76, 1827, 10.2106/00004623-199412000-00009

Saiz, 2004, Results of giant cell tumor of bone treated with intralesional excision, Clin Orthop Relat Res, 221

Wada, 2002, Complications associated with bone cementing for the treatment of giant cell tumors of bone, J Orthop Sci, 7, 194, 10.1007/s007760200033

Malawer, 1999, Cryosurgery in the treatment of giant cell tumor. A long-term followup study, Clin Orthop Relat Res, 176

Marcove, 1994, Conservative surgery for giant cell tumors of the sacrum. The role of cryosurgery as a supplement to curettage and partial excision, Cancer, 74, 1253, 10.1002/1097-0142(19940815)74:4<1253::AID-CNCR2820740412>3.0.CO;2-9

Schreuder, 1999, Beneficial effects of cryosurgical treatment in benign and low-grade-malignant bone tumors in 120 patients [in Dutch], Ned Tijdschr Geneeskd, 143, 2275

Marcove, 1978, Cryosurgery in the treatment of giant cell tumors of bone: A report of 52 consecutive cases, Clin Orthop Relat Res, 275

Jacobs, 1985, The closed cryosurgical treatment of giant cell tumor, Clin Orthop Relat Res, 149

Alkalay, 1996, Giant cell tumors with intraarticular fracture. Two-stage local excision, cryosurgery and cementation in 5 patients with distal femoral tumor followed for 2-4 years, Acta Orthop Scand, 67, 291, 10.3109/17453679608994692

Abdelrahman, 2009, Cryosurgery and impaction subchondral bone graft for the treatment of giant cell tumor around the knee, HSS J, 5, 123, 10.1007/s11420-009-9125-8

Wittig, 2001, Giant cell tumor of the hand: Superior results with curettage, cryosurgery, and cementation, J Hand Surg Am, 26, 546, 10.1053/jhsu.2001.22525

Gortzak, 2010, The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro study, J Bone Joint Surg Br, 92, 1475, 10.1302/0301-620X.92B10.23495

Blackley, 1999, Treatment of giant-cell tumors of long bones with curettage and bone-grafting, J Bone Joint Surg Am, 81, 811, 10.2106/00004623-199906000-00008

Lin, 2011, Similar local control between phenol- and ethanol-treated giant cell tumors of bone, Clin Orthop Relat Res, 469, 3200, 10.1007/s11999-011-1962-3

Schreuder, 1997, Monitoring during cryosurgery of bone tumors, J Surg Oncol, 65, 40, 10.1002/(SICI)1096-9098(199705)65:1<40::AID-JSO8>3.0.CO;2-O

Veth, 2005, Cryosurgery in aggressive, benign, and low-grade malignant bone tumours, Lancet Oncol, 6, 25, 10.1016/S1470-2045(05)70023-1

Prosser, 2005, Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone?, Clin Orthop Relat Res, 211

Yanagawa, 2009, Curettage of benign bone tumors without grafts gives sufficient bone strength, Acta Orthop, 80, 9, 10.1080/17453670902804604

Suzuki, 2007, Re-operation results in osteoarthritic change of knee joints in patients with giant cell tumor of bone, Knee, 14, 369, 10.1016/j.knee.2007.05.008

Bini, 1995, Giant cell tumor of bone. Curettage and cement reconstruction, Clin Orthop Relat Res, 245

Fraquet, 2009, Long bones giant cells tumors: Treatment by curretage and cavity filling cementation, Orthop Traumatol Surg Res, 95, 402, 10.1016/j.otsr.2009.07.004

Van der Heijden, 2013, Giant cell tumor with pathologic fracture: Should we curette or resect?, Clin Orthop Relat Res, 471, 820, 10.1007/s11999-012-2546-6

Balke, 2009, Treatment options for recurrent giant cell tumors of bone, J Cancer Res Clin Oncol, 135, 149, 10.1007/s00432-008-0427-x

Klenke, 2011, Recurrent giant cell tumor of long bones: Analysis of surgical management, Clin Orthop Relat Res, 469, 1181, 10.1007/s11999-010-1560-9

Deheshi, 2007, Joint salvage for pathologic fracture of giant cell tumor of the lower extremity, Clin Orthop Relat Res, 459, 96, 10.1097/BLO.0b013e31805d85e4

Chen, 2005, Giant cell tumors of the knee: Subchondral bone integrity affects the outcome, Int Orthop, 29, 30, 10.1007/s00264-004-0613-7

Van der Heijden, 2013, Mid-term outcome after curettage with polymethylmethacrylate for giant cell tumor around the knee: Higher risk of radiographic osteoarthritis?, J Bone Joint Surg Am, 95, e1591, 10.2106/JBJS.M.00066

Mankin, 2005, Treatment of giant cell tumors with allograft transplants: A 30-year study, Clin Orthop Relat Res, 439, 144, 10.1097/01.blo.0000174684.85250.b5

Jeys, 2005, Periprosthetic infection in patients treated for an orthopaedic oncological condition, J Bone Joint Surg Am, 87, 842, 10.2106/00004623-200504000-00021

Thangaraj, 2010, Giant cell tumour of the sacrum: A suggested algorithm for treatment, Eur Spine J, 19, 1189, 10.1007/s00586-009-1270-8

Martin, 2010, Giant cell tumor of the sacrum and spine: Series of 23 cases and a review of the literature, Iowa Orthop J, 30, 69

Guo, 2009, Outcome of conservative surgery for giant cell tumor of the sacrum, Spine (Phila Pa 1976), 34, 1025, 10.1097/BRS.0b013e31819d4127

Hosalkar, 2007, Serial arterial embolization for large sacral giant-cell tumors: Mid- to long-term results, Spine (Phila Pa 1976), 32, 1107, 10.1097/01.brs.0000261558.94247.8d

Lackman, 2002, The treatment of sacral giant-cell tumours by serial arterial embolisation, J Bone Joint Surg Br, 84, 873, 10.1302/0301-620X.84B6.0840873

Lin, 2002, Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization, Cancer, 95, 1317, 10.1002/cncr.10803

Balke, 2009, Treatment and outcome of giant cell tumors of the pelvis, Acta Orthop, 80, 590, 10.3109/17453670903350123

Balke, 2012, Giant cell tumors of the axial skeleton, Sarcoma, 410973

Sar, 2002, Surgical treatment of primary tumors of the sacrum, Arch Orthop Trauma Surg, 122, 148, 10.1007/s00402-001-0356-5

Wuisman, 2000, Total sacrectomy and reconstruction: Oncologic and functional outcome, Clin Orthop Relat Res, 192

Ruggieri, 2010, Recurrence after and complications associated with adjuvant treatments for sacral giant cell tumor, Clin Orthop Relat Res, 468, 2954, 10.1007/s11999-010-1448-8

Xu, 2013, Factors affecting prognosis of patients with giant cell tumors of the mobile spine: Retrospective analysis of 102 patients in a single center, Ann Surg Oncol, 20, 804, 10.1245/s10434-012-2707-6

Kollender, 2003, Role of adjuvant cryosurgery in intralesional treatment of sacral tumors, Cancer, 97, 2830, 10.1002/cncr.11383

Tse, 2008, Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: A case-control study, Bone, 42, 68, 10.1016/j.bone.2007.08.038

Yu, 2013, Clinical outcomes of giant cell tumor of bone treated with bone cement filling and internal fixation, and oral bisphosphonates, Oncol Lett, 5, 447, 10.3892/ol.2012.1036

Kostenuik, 2009, Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL, J Bone Miner Res, 24, 182, 10.1359/jbmr.081112

Adler, 2011, Clinical utility of denosumab for treatment of bone loss in men and women, Clin Interv Aging, 6, 119, 10.2147/CIA.S14565

Cavalli, 2012, Targeted approaches in the treatment of osteoporosis: Differential mechanism of action of denosumab and clinical utility, Ther Clin Risk Manag, 8, 253

Shi, 2013, Radiotherapy in the management of giant cell tumor of bone, Am J Clin Oncol, 36, 505, 10.1097/COC.0b013e3182568fb6

Bhatia, 2011, Radiotherapy for marginally resected, unresectable or recurrent giant cell tumor of the bone: A rare cancer network study, Rare Tumors, 3, e48, 10.4081/rt.2011.e48

Ruka, 2010, The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone, Int J Radiat Oncol Biol Phys, 78, 494, 10.1016/j.ijrobp.2009.07.1704

Caudell, 2003, Radiotherapy in the management of giant cell tumor of bone, Int J Radiat Oncol Biol Phys, 57, 158, 10.1016/S0360-3016(03)00416-4

Chakravarti, 1999, Megavoltage radiation therapy for axial and inoperable giant-cell tumor of bone, J Bone Joint Surg Am, 81, 1566, 10.2106/00004623-199911000-00008

Feigenberg, 2003, Radiation therapy for giant cell tumors of bone, Clin Orthop Relat Res, 207

Malone, 1995, Long-term follow-up of efficacy and safety of megavoltage radiotherapy in high-risk giant cell tumors of bone, Int J Radiat Oncol Biol Phys, 33, 689, 10.1016/0360-3016(95)00159-V

Miszczyk, 2001, Efficacy of radiotherapy for giant cell tumor of bone: Given either postoperatively or as sole treatment, Int J Radiat Oncol Biol Phys, 49, 1239, 10.1016/S0360-3016(00)01520-0

Nair, 1999, Radiation therapy in the treatment of giant cell tumor of bone, Int J Radiat Oncol Biol Phys, 43, 1065, 10.1016/S0360-3016(98)00526-4

Bennett, 1993, Radiation therapy for giant cell tumor of bone, Int J Radiat Oncol Biol Phys, 26, 299, 10.1016/0360-3016(93)90210-M

Schwartz, 1989, Radiation therapy in the treatment of difficult giant cell tumors, Int J Radiat Oncol Biol Phys, 17, 1085, 10.1016/0360-3016(89)90160-0

Benevenia, 2012, Comparison of phenol and argon beam coagulation as adjuvant therapies in the treatment of stage 2 and 3 benign-aggressive bone tumors, Orthopedics, 35, e371, 10.3928/01477447-20120222-22