The Chimeric Antigen Receptor Detection Toolkit
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Maude, 2018, Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia, N Engl J Med, 378, 439, 10.1056/NEJMoa1709866
Neelapu, 2017, Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma, N Engl J Med, 377, 2531, 10.1056/NEJMoa1707447
Li, 2018, Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward, J Hematol Oncol, 11, 22, 10.1186/s13045-018-0568-6
Gumba, 2019, Implementation of good clinical laboratory practice in an immunology basic research laboratory, Am J Clin Pathol, 151, 270, 10.1093/ajcp/aqy138
Liu, 2019, Building potent chimeric antigen receptor T cells with CRISPR genome editing, Front Immunol, 10, 456, 10.3389/fimmu.2019.00456
Hamada, 2018, Integration mapping of piggybac-mediated CD19 chimeric antigen receptor T cells analyzed by novel tagmentation-assisted PCR, EBioMedicine, 34, 18, 10.1016/j.ebiom.2018.07.008
Fraietta, 2018, Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia, Nat Med, 24, 563, 10.1038/s41591-018-0010-1
Wang, 2018, Establishment of a quantitative polymerase chain reaction assay for monitoring chimeric antigen receptor T cells in peripheral blood, Transplant Proc, 50, 104, 10.1016/j.transproceed.2017.11.028
Kunz, 2020, Optimized assessment of qPCR-based vector copy numbers as a safety parameter for GMP-grade CAR T cells and monitoring of frequency in patients, Mol Ther Methods Clin Dev, 17, 448, 10.1016/j.omtm.2020.02.003
Ståhlberg, 2018, Technical aspects and recommendations for single-cell qPCR, Mol Aspects Med, 59, 28, 10.1016/j.mam.2017.07.004
Fehse, 2020, Digital PCR assays for precise quantification of CD19-CAR-T cells after treatment with axicabtagene ciloleucel, Mol Ther Methods Clin Dev, 16, 172, 10.1016/j.omtm.2019.12.018
Santeramo, 2020, Vector copy distribution at a single cell level enhances analytical characterisation of gene-modified cell therapies, Mol Ther Methods Clin Dev, 17, 944, 10.1016/j.omtm.2020.04.016
Nobles, 2020, CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration, J Clin Invest, 130, 673, 10.1172/JCI130144
Fraietta, 2018, Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells, Nature, 558, 307, 10.1038/s41586-018-0178-z
Hacien-Bey-Abina, 2003, LMO2-Associated clonal T cell proliferation in two patients after gene therapy for SCID-X1, Science., 302, 415, 10.1126/science.1088547
Wu, 2003, Transcription start regions in the human genome are favored targets for MLV integration, Science., 300, 1749, 10.1126/science.1083413
Brady, 2011, A method to sequence and quantify DNA integration for monitoring outcome in gene therapy, Nucl Acids Res, 39, e72, 10.1093/nar/gkr140
Berry, 2017, INSPIIRED: quantification and visualization tools for analyzing integration site distributions, Mol Ther Methods Clin Dev, 4, 17, 10.1016/j.omtm.2016.11.003
Sherman, 2017, INSPIIRED: a pipeline for quantitative analysis of sites of new DNA integration in cellular genomes, Mol Ther Methods Clin Dev, 4, 39, 10.1016/j.omtm.2016.11.002
Wang, 2020, Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels, Proc Natl Acad Sci USA, 117, 5442, 10.1073/pnas.1919259117
Berry, 2012, Estimating abundances of retroviral insertion sites from DNA fragment length data, Bioinformatics, 28, 755, 10.1093/bioinformatics/bts004
Gomes-Silva, 2017, Tonic 4-1BB costimulation in chimeric antigen receptors impedes T cell survival and is vector-dependent, Cell Rep, 21, 17, 10.1016/j.celrep.2017.09.015
Walker, 2017, Tumor antigen and receptor densities regulate efficacy of a chimeric antigen receptor targeting anaplastic lymphoma kinase, Mol Ther, 25, 2189, 10.1016/j.ymthe.2017.06.008
Zhang, 2019, Transcriptome and regulatory network analyses of CD19-CAR-T immunotherapy for B-ALL, Genomics Proteomics Bioinform, 17, 190, 10.1016/j.gpb.2018.12.008
Sheih, 2020, Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy, Nat Commun, 11, 219, 10.1038/s41467-019-13880-1
Wang, 2013, Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation, Exp Hematol, 41, 934, 10.1016/j.exphem.2013.07.002
Wang, 2012, RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues, J Mol Diagnostics, 14, 22, 10.1016/j.jmoldx.2011.08.002
O'Rourke, 2017, A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma, Sci Transl Med, 9, eaaa0984, 10.1126/scitranslmed.aaa0984
Pimentel, 2019, Abstract 2324: preclinical safety, biodistribution, and tumor infiltration analysis of CAR T cell targets using in situ hybridization technology, Immunology, 2324, 10.1158/1538-7445.AM2019-2324
Yang, 2017, TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance, Sci Transl Med, 9, eaag1209, 10.1126/scitranslmed.aag1209
Hamieh, 2019, CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape, Nature, 568, 112, 10.1038/s41586-019-1054-1
Kochenderfer, 2009, Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor, J Immunother, 32, 689, 10.1097/CJI.0b013e3181ac6138
Nilson, 1993, Purification of antibodies using protein L-binding framework structures in the light chain variable domain, J Immunol Methods, 164, 33, 10.1016/0022-1759(93)90273-A
Zheng, 2012, Protein L: a novel reagent for the detection of chimeric antigen receptor (CAR) expression by flow cytometry, J Transl Med, 10, 29, 10.1186/1479-5876-10-29
Han, 2017, Masked chimeric antigen receptor for tumor-specific activation, Mol Ther, 25, 274, 10.1016/j.ymthe.2016.10.011
Long, 2015, 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors, Nat Med, 21, 581, 10.1038/nm.3838
Sun, 2014, Construction and evaluation of a novel humanized HER2-specific chimeric receptor, Breast Cancer Res, 16, R61, 10.1186/bcr3674
Ruella, 2016, Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies, J Clin Invest, 126, 3814, 10.1172/JCI87366
De Oliveira, 2013, A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors, J Transl Med, 11, 23, 10.1186/1479-5876-11-23
Chang, 2018, Rewiring T-cell responses to soluble factors with chimeric antigen receptors, Nat Chem Biol, 14, 317, 10.1038/nchembio.2565
Teplyakov, 2018, Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold, Proteins Struct Funct Bioinforma, 86, 495, 10.1002/prot.25485
Lobner, 2020, Getting CD19 into shape: expression of natively folded “difficult-to-express” CD19 for staining and stimulation of CAR-T cells, Front Bioeng Biotechnol, 8, 49, 10.3389/fbioe.2020.00049
Toebes, 2009, Generation of peptide MHC class I monomers and multimers through ligand exchange, Curr Protoc Immunol, 10.1002/0471142735.im1816s87
Bentzen, 2017, Evolution of MHC-based technologies used for detection of antigen-responsive T cells, Cancer Immunol Immunother, 66, 657, 10.1007/s00262-017-1971-5
Huang, 2016, Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer, Proc Natl Acad Sci USA, 113, E1890, 10.1073/pnas.1602488113
Batard, 2006, Dextramers: new generation of fluorescent MHC class I/peptide multimers for visualization of antigen-specific CD8+ T cells, J Immunol Methods, 310, 136, 10.1016/j.jim.2006.01.006
Jena, 2013, Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials, PLoS ONE, 8, e57838, 10.1371/journal.pone.0057838
Lee, 2015, T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial, Lancet, 385, 517, 10.1016/S0140-6736(14)61403-3
Ruella, 2017, A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor (CAR19) positive cells, Blood, 130, 4463, 10.1182/blood.V130.Suppl_1.4463.4463
Yvon, 2009, Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells, Clin Cancer Res, 15, 5852, 10.1158/1078-0432.CCR-08-3163
Sievers, 2019, Abstract 1204: design and development of anti-linker antibodies for the detection and characterization of CAR T cells, Experimental and Molecular Therapeutics., 1204, 10.1158/1538-7445.AM2019-1204
Chen, 2018, Analysis of CAR-T and immune cells within the tumor micro-environment of diffuse large B-cell lymphoma post CAR-T treatment by multiplex immunofluorescence, Blood, 132, 678, 10.1182/blood-2018-99-113644
Gopalakrishnan, 2019, A novel luciferase-based assay for the detection of chimeric antigen receptors, Sci Rep, 9, 1957, 10.1038/s41598-018-38258-z
Ramello, 2019, An immunoproteomic approach to characterize the CAR interactome and signalosome, Sci Signal, 12, eaap9777, 10.1126/scisignal.aap9777
Salter, 2018, Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function, Sci Signal, 11, eaat6753, 10.1126/scisignal.aat6753
Davenport, 2018, Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity, Proc Natl Acad Sci USA, 115, E2068, 10.1073/pnas.1716266115
Jang, 2015, Imaging of cell–cell communication in a vertical orientation reveals high-resolution structure of immunological synapse and novel PD-1 dynamics, J Immunol, 195, 1320, 10.4049/jimmunol.1403143
Xiong, 2018, Immunological synapse predicts effectiveness of chimeric antigen receptor cells, Mol Ther, 26, 963, 10.1016/j.ymthe.2018.01.020
Libby, 2020, T-cell receptor signaling, Methods in Molecular Biology., 153
Su, 2018, Mechanisms of chimeric antigen receptor (CAR) signaling during T cell activation, Biophys J, 114, 107a, 10.1016/j.bpj.2017.11.625
Morrissey, 2018, Chimeric antigen receptors that trigger phagocytosis, Elife, 7, e36688, 10.7554/eLife.36688
Sasmal, 2020, TCR–pMHC bond conformation controls TCR ligand discrimination, Cell Mol Immunol, 17, 203, 10.1038/s41423-019-0273-6
Rosenberg, 2019, Visualizing surface T-cell receptor dynamics four-dimensionally using lattice light-sheet microscopy, J Vis Exp, 2020, e59914, 10.3791/59914
Rosenberg, 2020, Lattice light-sheet microscopy multi-dimensional analyses (LaMDA) of T-cell receptor dynamics predict T-cell signaling states, Cell Syst, 10, 433, 10.1016/j.cels.2020.04.006
Nerreter, 2019, Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T, Nat Commun, 10, 3137, 10.1038/s41467-019-10948-w
Torres Chavez, 2019, Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity, J Immunother Cancer, 7, 330, 10.1186/s40425-019-0804-9
Dawson, 2019, Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells, JCI Insight, 4, e123672, 10.1172/jci.insight.123672
Serganova, 2017, Enhancement of PSMA-directed CAR adoptive immunotherapy by PD-1/PD-L1 blockade, Mol Ther Oncolytics, 4, 41, 10.1016/j.omto.2016.11.005
Stowe, 2019, Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin, Elife, 8, e45801, 10.7554/eLife.45801
Keu, 2017, Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma, Sci Transl Med, 9, eaag2196, 10.1126/scitranslmed.aag2196
Krebs, 2018, Antibody with infinite affinity for in vivo tracking of genetically engineered lymphocytes, J Nucl Med, 59, 1894, 10.2967/jnumed.118.208041
Sellmyer, 2019, Imaging CAR T cell trafficking with eDFHR as a PET reporter gene, Mol Ther, 28, 42, 10.1016/j.ymthe.2019.10.007
Park, 2017, Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity, Sci Rep, 7, 14366, 10.1038/s41598-017-14749-3
Bhanat, 2018, Somatostatin receptor expression in non-classical locations – clinical relevance?, Rev Endocr Metab Disord, 19, 123, 10.1007/s11154-018-9470-3
Emami-Shahri, 2018, Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells, Nat Commun, 9, 1081, 10.1038/s41467-018-03524-1
Minn, 2019, Imaging CAR T cell therapy with PSMA-targeted positron emission tomography, Sci Adv, 5, eaaw5096, 10.1126/sciadv.aaw5096
Lee, 2020, Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging, PLoS ONE, 15, e0223814, 10.1371/journal.pone.0223814
Mezzanotte, 2017, In vivo molecular bioluminescence imaging: new tools and applications, Trends Biotechnol, 35, 640, 10.1016/j.tibtech.2017.03.012
Kuchimaru, 2016, A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging, Nat Commun, 7, 11856, 10.1038/ncomms11856
Alavi, 2008, Positron emission tomography in medicine: an overview, Cancer Imaging, 31, 39, 10.1016/B978-012374212-4.50009-2
Eissenberg, 2014, Suicide genes: monitoring cells in patients with a safety switch, Front Pharmacol, 5, 5, 10.3389/fphar.2014.00241
Ishii, 2011, Intravital two-photon imaging: a versatile tool for dissecting the immune system, Ann Rheum Dis, 70, 113, 10.1136/ard.2010.138156
Cazaux, 2019, Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity, J Exp Med, 216, 1038, 10.1084/jem.20182375
Mulazzani, 2019, Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice, Proc Natl Acad Sci USA, 116, 24275, 10.1073/pnas.1903854116
Ma, 2018, Two-photon fluorescent polydopamine nanodots for CAR-T cell function verification and tumor cell/tissue detection, J Mater Chem B, 6, 6459, 10.1039/C8TB01930D