The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms

Translational Stroke Research - Tập 8 Số 1 - Trang 67-76 - 2017
Lau, Wei Ling1, Huisa, Branko N.2, Fisher, Mark3,4
1Department of Medicine, Division of Nephrology, University of California, Irvine, USA
2Department of Neurology, University of California, San Diego, USA
3Departments of Neurology, Anatomy & Neurobiology, and Pathology & Laboratory Medicine, University of California, Irvine, USA
4Department of Neurology, UC Irvine Medical Center, Orange, USA

Tóm tắt

Chronic kidney disease (CKD) is an independent risk factor for the development of cerebrovascular disease, particularly small vessel disease which can manifest in a variety of phenotypes ranging from lacunes to microbleeds. Small vessel disease likely contributes to cognitive dysfunction in the CKD population. Non-traditional risk factors for vascular injury in uremia include loss of calcification inhibitors, hyperphosphatemia, increased blood pressure variability, elastinolysis, platelet dysfunction, and chronic inflammation. In this review, we discuss the putative pathways by which these mechanisms may promote cerebrovascular disease and thus increase risk of future stroke in CKD patients.

Tài liệu tham khảo

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