The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function
Christopher N. Johnson1,2, Rekha Pattanayek3, Franck Potet4, Robyn T. Rebbeck5, Daniel J. Blackwell1, Roman Nikolaienko6, Vasco Sequeira7, Remy Le Meur8, Przemysław B. Radwański2, Jonathan P. Davis2, Aleksey V. Zima6, Razvan L. Cornea5, Steven M. Damo3, Sandor Györke2, Alfred L. George4, Björn C. Knollmann1
1Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37240, USA
2Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA
3Department of Life and Physical Sciences, Fisk University, Nashville, TN 37208, USA
4Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
5Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
6Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University, Maywood IL, 60153, USA
7Department of Translational Science Universitätsklinikum, Würzburg, Germany
8Department of Biochemistry, Vanderbilt University, Nashville TN 37204, USA