The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana
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Mottram, 1993, A novel CDC2-related protein kinase from Leishmania mexicana, lmmCRK1, is post-translationally regulated during the life-cycle, J. Biol. Chem., 268, 21044, 10.1016/S0021-9258(19)36891-7
Grant, 1998, The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12cks1, J. Biol. Chem., 273, 10153, 10.1074/jbc.273.17.10153
Wang, 1998, Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant, Mol. Biochem. Parasitol., 96, 139, 10.1016/S0166-6851(98)00121-2
Nigg, 1995, Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle, Bioessays, 17, 471, 10.1002/bies.950170603
Beach, 1982, Functionally homologous cell cycle control genes in budding and fission yeast, Nature, 300, 706, 10.1038/300706a0
Wittenberg, 1988, Control of the yeast cell cycle is associated with assembly disassembly of the cdc28 protein kinase complex, Cell, 54, 1061, 10.1016/0092-8674(88)90121-3
Pagano, 1993, Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts, J. Cell Biol., 121, 101, 10.1083/jcb.121.1.101
Riabowol, 1989, The cdc2 kinase is a nuclear-protein that is essential for mitosis in mammalian-cells, Cell, 57, 393, 10.1016/0092-8674(89)90914-8
Mottram, 1996, Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana, Mol. Microbiol., 22, 573, 10.1046/j.1365-2958.1996.00136.x
Mottram, 1996, Leishmania mexicana p12cks1, a functional homologue of fission yeast p13suc1, associates with a stage-regulated histone H1 kinase, Biochem. J., 316, 833, 10.1042/bj3160833
Cordon-Cardo, 1995, Tumor-suppressor genes, Cancer, 75
Karp, 1995, Molecular foundations of cancer — new targets for intervention, Nature Med., 1, 309, 10.1038/nm0495-309
Meijer, 1996, Chemical inhibitors of cyclin-dependent kinases, Trends Cell Biol., 6, 393, 10.1016/0962-8924(96)10034-9
Meijer, 1997, Chemical inhibitors of cyclin-dependent kinases, Methods Enzymol., 283, 113, 10.1016/S0076-6879(97)83011-X
Doerig, 2000, The cell cycle of protozoan parasites, 163
Schulze-Gahmen, 1995, Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine, Proteins, 22, 378, 10.1002/prot.340220408
De Azevedo, 1996, Structural basis for the specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase, Proc. Natl. Acad. Sci. USA, 93, 2735, 10.1073/pnas.93.7.2735
De Azevedo, 1997, Inhibition of cyclin-dependent kinases by purine analogues — crystal structure of human cdk2 complexed with roscovitine, Eur. J. Biochem., 243, 518, 10.1111/j.1432-1033.1997.0518a.x
Hoessel, 1999, Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases, Nat. Cell Biology, 1, 60, 10.1038/9035
Rialet, 1991, A new screening test for antimitotic compounds using the universal M-phase specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilised on p13suc1-coated microtitration plates, Anticancer Res., 11, 1581
Gadbois, 1992, Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases, Biochem. Biophys. Res. Commun., 184, 80, 10.1016/0006-291X(92)91160-R
Kitagawa, 1993, Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase, Oncogene, 8, 2425
Sedlacek, 1996, Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy, Int. J. Oncol., 9, 1143
Czech, 1995, Antitumoral activity of flavone L86 8275, Int. J. Oncol., 6, 31
Losiewicz, 1994, Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275, Biochem. Biophys. Res. Commun., 201, 589, 10.1006/bbrc.1994.1742
Carlson, 1996, Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK)2 and CDK4 in human breast carcinoma cells, Cancer Res., 56, 2973
Worland, 1993, Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity, Biochem. Pharmacol., 46, 1831, 10.1016/0006-2952(93)90590-S
Graeser, 1996, Plasmodium falciparum protein kinase 5 and the malarial nuclear division cycles, Mol. Biochem. Parasitol., 82, 37, 10.1016/0166-6851(96)02716-8
Senderowicz, 1999, Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials, Invest. New Drugs, 17, 313, 10.1023/A:1006353008903
Souza, 1994, Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana, Mol. Biochem. Parasitol., 63, 213, 10.1016/0166-6851(94)90057-4
Kelly, 1992, A shuttle vector, which facilitates the expression of transfected genes in Trypanosoma cruzi and Leishmania, Nucleic Acids Res., 20, 3963, 10.1093/nar/20.15.3963
Coburn, 1991, Stable DNA transfection of a wide range of trypanosomatids, Mol. Biochem. Parasitol., 46, 169, 10.1016/0166-6851(91)90210-W
Mottram, 1996, Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors, Proc. Natl. Acad. Sci. USA, 93, 6008, 10.1073/pnas.93.12.6008
Medina-Acosta, 1993, Rapid isolation of DNA from trypanosomatid protozoa using a simple mini-prep procedure, Mol. Biochem. Parasitol., 59, 327, 10.1016/0166-6851(93)90231-L
Tovar, 1996, Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi, Nucleic Acids Res., 24, 2942, 10.1093/nar/24.15.2942
Cruz, 1993, Plasticity in chromosome number and testing of essential genes in Leishmania by targeting, Proc. Natl. Acad. Sci. USA, 90, 1599, 10.1073/pnas.90.4.1599
Barrett, 1999, Recent advances in identifying and validating drug targets in trypanosomes and leishmanias, Trends Microbiol., 7, 82, 10.1016/S0966-842X(98)01433-4
Dumas, 1997, Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages, EMBO J., 16, 2590, 10.1093/emboj/16.10.2590
Tovar, 1998, Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus, Mol. Microbiol., 29, 653, 10.1046/j.1365-2958.1998.00968.x
Reed, 1985, Protein kinase activity associated with the product of the yeast cell division cycle gene cdc28, Proc. Natl. Acad. Sci. USA, 82, 4055, 10.1073/pnas.82.12.4055
Gray, 1998, Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors, Science, 281, 533, 10.1126/science.281.5376.533
Zaharevitz, 1999, Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases, Cancer Res., 59, 2566