The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study

Springer Science and Business Media LLC - 2023
Charlotte L Hall1,2, Louise Marston3, Kareem Khan2,1, Beverley J Brown2, Charlotte Sanderson4,5, Per Andrén6, Sophie Bennett5,4, Isobel Heyman4, David Mataix–Cols6, Eva Serlachius6, Chris Hollis1,2, Tara Murphy4,5
1NIHR Nottingham Biomedical Research Centre, Institute of Mental Health, Mental Health & Clinical Neurosciences, University of Nottingham, Nottingham, UK
2Institute of Mental Health, School of Medicine, Mental Health & Clinical Neurosciences, NIHR MindTech MedTech Co-operative, University of Nottingham, Nottingham, UK
3Research Department of Primary Care and Population Health and Priment CTU, University College London, London, UK
4UCL Great Ormond Street Institute of Child Health (ICH), London, UK
5Psychological and Mental Health Services, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
6Centre for Psychiatry Research, Department of Clinical Neuroscience, Stockholm Health Care Services, Karolinska Institutet, Region Stockholm, Stockholm, Sweden

Tóm tắt

AbstractTo understand how children and young people with tic disorders were affected by COVID-19, we compared pre and during pandemic scores on the Yale Global Tic Severity Scale (YGTSS). Participants were young people (N = 112; male:78%; 9–17 years) randomised to the control arm of the “ORBIT-Trial” (ISRCTN70758207, ClinicalTrials.gov-NCT03483493). For this analysis, the control arm was split into two groups: one group was followed up to 12-months’ post-randomisation before the pandemic started (pre-COVID group, n = 44); the other group was impacted by the pandemic at the 12-month follow-up (during-COVID group, n = 47). Mixed effects linear regression modelling was conducted to explore differences in YGTSS at 6- and 12-months post-randomisation. There were no significant differences in tic symptom or severity between participants who were assessed before and during COVID-19. This finding was not influenced by age, gender, symptoms of anxiety or autism spectrum disorder. Thus, the COVID-19 pandemic did not significantly impact existing tic symptoms.

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