The Biomechanics of Arterial Aneurysms

Annual Review of Fluid Mechanics - Tập 39 Số 1 - Trang 293-319 - 2007
Juan C. Lasheras1
1Department of Mechanical and Aerospace Engineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0411;

Tóm tắt

The formation of an arterial aneurysm is believed to be a multifactorial and predominantly degenerative process, resulting from a complex interplay between biological processes in the arterial wall and the hemodynamic stimuli on the vessel's wall. Once an aneurysm forms, the repetitive pressure and shear stresses exerted by the blood flow on the weakened arterial wall generally, but not always, cause a gradual expansion. As the wall geometry, composition, and strength progressively degrade through the enlargement process, the aneurysm ruptures when the wall of the distended artery fails to support the stresses resulting from the internal blood flow. This review surveys recent progress in this area and provides a critical assessment of the contribution made by hemodynamics studies to the current understanding of the pathogenesis of the disease and to its clinical management.

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Annual Review of Fluid Mechanics

Tập 39 Số 1

293-319

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